DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CUL1 and Cul1

DIOPT Version :9

Sequence 1:NP_001357589.1 Gene:CUL1 / 8454 HGNCID:2551 Length:776 Species:Homo sapiens
Sequence 2:NP_523655.1 Gene:Cul1 / 35742 FlyBaseID:FBgn0015509 Length:774 Species:Drosophila melanogaster


Alignment Length:779 Identity:489/779 - (62%)
Similarity:595/779 - (76%) Gaps:31/779 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    13 KQIGLDQIWDDLRAGIQQVYTRQ-SMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQ 76
            |.:.||.||.:|..||.||:..: |:.:|:||..|||||:|||||         ...||....|:
  Fly    12 KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSV---------SAAPSGRSSGK 67

Human    77 TPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKVLNGICAYL 140
            | ||||.||.:||.||::|||:||:.||...:.:..|.| |..||:||:.|:|||.||:|||.||
  Fly    68 T-GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYL 131

Human   141 NRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVV 205
            ||:||:|||:||:||||:||.||||.|:..||:.||:.||.||||.||:||.|:.||..|:..|:
  Fly   132 NRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVI 196

Human   206 QSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLE 270
            :.||||..||:|..|:...|:|||::||::|:|||..||.:||..||..|.||||:|..|.||.|
  Fly   197 ECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEE 261

Human   271 EQRRVQ--------VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVS 327
            |.:||:        .||||:|.|.|...||:|||||||:||||||||||:||:|:||.|||:||:
  Fly   262 ETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSLVA 326

Human   328 RIQDGLGELKKLLETHIHNQGLAAIEKCGEA-ALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGF 391
            .....|.:||.:||.||.:||..||.||... |.||||.||||:|||||||||||::|||||.||
  Fly   327 LSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGF 391

Human   392 VAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYI 456
            |||||||||:|||:|.|| :|.|:||||||||:|||.||||||||||:.||||.|||||||||||
  Fly   392 VAALDKACGKFINSNVVT-IANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYI 455

Human   457 EDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQF 521
            ||||||||:|:||||||||:..||||||||.|||||||.||:|||.||||||||||||||||..|
  Fly   456 EDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYF 520

Human   522 KKHLTNSE-PLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQL 585
            |::|.... .:::||.|:||||||||||.|..|.||||||||.::|..|||:|||||||.||||:
  Fly   521 KQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQM 585

Human   586 SKGELVTNCFKNR---YTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSK 647
            .||||:.|..:|.   ||||||||||::|||:|.:.::|||||.|:||.:.:.|.||||||||:|
  Fly   586 CKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAK 650

Human   648 LLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQ 712
            :|...|     :|..|.|::.::|:|.|||||.|:|||.|:|||.|.||||.||:||||||||||
  Fly   651 VLTSSD-----NENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQ 710

Human   713 AAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
            |||||||||||.|.|..|:.|||.|||:||||:|||||||||||||||||||::|.||||||||
  Fly   711 AAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CUL1NP_001357589.1 Cullin 21..660 CDD:395716 398/653 (61%)
Cullin_Nedd8 706..767 CDD:402267 50/60 (83%)
Cul1NP_523655.1 Cullin 21..669 CDD:279260 400/663 (60%)
CULLIN 454..593 CDD:214545 100/138 (72%)
Cullin_Nedd8 701..765 CDD:214883 53/63 (84%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158840
Domainoid 1 1.000 759 1.000 Domainoid score I88
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2663
Inparanoid 1 1.050 930 1.000 Inparanoid score I351
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 1 1.000 - - FOG0003709
OrthoInspector 1 1.000 - - oto90071
orthoMCL 1 0.900 - - OOG6_101330
Panther 1 1.100 - - LDO PTHR11932
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R262
SonicParanoid 1 1.000 - - X1841
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1514.840

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