DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CUL1 and Cul2

DIOPT Version :9

Sequence 1:	NP_001357589.1	Gene:	CUL1 / 8454	HGNCID:	2551	Length:	776	Species:	Homo sapiens
Sequence 2:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster

Alignment Length:	791	Identity:	280/791 - (35%)
Similarity:	430/791 - (54%)	Gaps:	84/791 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    20 IWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFV 84
            :|..||...:.|.|...:.:|.:...::.||..|.:..:....|
  Fly    13 VWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADR--------------------- 56

Human    85 GLELYKRLKEFLKNYLTNLL-------------KDGEDLMDESVLKFYTQQWEDYRFSSKVLNGI 136
               ||...|.||:.::..:|             ..|.||     |:.|...|.:|....|.|:.:
  Fly    57 ---LYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDL-----LQRYYITWMEYSQGIKYLHQL 113

Human   137 CAYLNRHWVRRECDEGRKGIY-----------EIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKE 190
            ..|||:..::::.....:..|           ||..|.|..||..:...|:.::...:|:.|..:
  Fly   114 YIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAAD 178

Human   191 R--NGETINTR--LISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEF 251
            |  ||...:.|  :|:||:.|:||:   :|  :.|..:|.:|:|.||...|..:..:||.|:.:.
  Fly   179 RASNGTLDHHRVQIINGVIHSFVEV---QD--YKKTGSLKLYQELFEGPMLEASGAYYTDEANKL 238

Human   252 LQQNPVTEYMKKAEARLLE-EQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADK 315
            |.:..|:|||::. .|:|| |.||.|.:||.|:..:|.::||:..|...|...::|.:.::..::
  Fly   239 LHRCSVSEYMQEV-IRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEER 302

Human   316 NEDLGRMYNLVSRIQDGL-GELKKLLETHIHNQGLAAIEKC-GEAALNDPKMYVQTVLDVHKKYN 378
            .:||..||.::..|.|.| .||......||.::||..:... ||   |....:|:.:|.||.||.
  Fly   303 RQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTVSALKGE---NIHIAFVENMLKVHHKYQ 364

Human   379 ALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELE 443
            .|:...|.||:.|::||||||...||.....:   ...:|.|.:|:|||:|||||...  |||::
  Fly   365 ELIADVFENDSLFLSALDKACASVINRRPTER---QPCRSAEYVAKYCDTLLKKSKTC--EAEID 424

Human   444 DTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMF 508
            ..|...:.:|||||||||:||||:::|||||:|:.|.|.|||..||::||||||:|:|:||.|||
  Fly   425 QKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMF 489

Human   509 QDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPF--QQSCTFALPSELERSYQRFTAFY 570
            .||.||.|||.:|..||.:|. .|.::.:|:||.:|:||.  .|...||:|.|.|:|.:.|..:|
  Fly   490 TDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYY 554

Human   571 ASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDI 635
            ....||||||||:.:..|||..:..|..|.:...|:||||:|.:.|.|:.:.:::.::.|:..:.
  Fly   555 HKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDET 619

Human   636 LAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTH 700
            ..:.:|.:::||||....||       |..:|.|:|.|.|.||:.:..|:..::.|..||.|.|.
  Fly   620 FQKHMQPIIESKLLNASSEN-------LAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTI 677

Human   701 KNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERV 765
            .:::|||||.:|||||||||.||||||..|:.|||:.....|.|.:.:||||::.||:|:|:||.
  Fly   678 NSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERT 742

Human   766 DGEKDTYSYLA 776
            ....|.|||:|
  Fly   743 ANSGDEYSYMA 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CUL1	NP_001357589.1	Cullin	21..660	CDD:395716	225/672 (33%)
CUL1	NP_001357589.1	Cullin_Nedd8	706..767	CDD:402267	35/60 (58%)
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	217/642 (34%)
		CULLIN	436..575	CDD:214545	74/138 (54%)
		Cullin_Nedd8	680..745	CDD:214883	36/64 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830