Protein Alignment CUL2 and Cul5

DIOPT Version :10

• Sequence 1: XP_011518045.1
• Gene: CUL2 / 8453
• HGNCID: 2552
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0288875
• Length: 852
• Species: Drosophila melanogaster
• Alignment Length: 860
• Identity: 225/860 - (26%)
• Similarity: 392/860 - (45%)
• Gaps: 144/860 - (16%)

Human    73 FDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLY-------TETKIFLEN 130
            |:|.|......:..::..:.|.:..|.|.|..::.:|: :.|....::|       .|..:..::
  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCL-WDEKGAAKIYDCLQQDIVEFIVQAQS 76

Human   131 HVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYL------------------------ 171
            .|     :....|:.:|..|...|.::...::|:...:|.|
  Fly    77 QV-----QAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSASGA 136

Human   172 NTQFIKKNKLTEADLQYGYGGVDMN---------------------------------------- 196
            :|........|....|.|..|...:
  Fly   137 STSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTS 201

Human   197 ----EPLME--IGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVE 255
                .|..:  :.:|.||.|.|.:...::..|....::.:..:|.|:..:.:::.||..|:|::.
  Fly   202 TSKKNPTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLS 266

Human   256 QYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPS 320
            . ..:..|:.|:|.||..:|..|.|:|:.:::...||:....||:....:|::||:|.::||.||
  Fly   267 S-NAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPS 330

Human   321 SYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAV--STGLPHMIQELQNHIH 383
            |::.:.:.....::.|||..:.|||..:||..:...:..|:.|:..|  ..|:..|:.:||.||.
  Fly   331 SFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIM 395

Human   384 DEG----LRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVN---- 440
            ..|    |.|:..:||::  ..:||.:||:..||..|:....|.|..|::|.|.|..:|||
  Fly   396 SAGLADMLSASEVITQDS--EKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSV 458

Human   441 ---------------YREPKSVCKAPELLAKYCDNLLKKS--AKGMTENEVEDRLTSFITVFKYI 488
                           |..|:|.|  |||||.|||.||:::  :|.:|..:::.||...:.|.||:
  Fly   459 FKMELPTSIANRGVKYTAPESKC--PELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYV 521

Human   489 DDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQ-ACGYEFTSKLHRMYTDMSVSADLNNK 552
            ::||||.:::...|.:|||.|.|...:.||.::..|:: ....::.::|.||:.|:.||.|||.:
  Fly   522 NNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQ 586

Human   553 FNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLT 617
            |...|...|.:       .|.:|.||||.......|. ::|.|||..:...|.||.:..|||||.
  Fly   587 FRTSISRHDAI-------NIKILNAGAWARCSERVSV-SLPIELEDYIPDVEEFYKKKHSGRKLQ 643

Human   618 WLHYLCTGEVK-MNYLGKPYVAMVTTYQMAVLLAFN--NSETVSYKELQDSTQMNEKELTKTIKS 679
            |.|::..|.:. :|..|: |...|||:|||||.|:|  ..:.:||:.|:.:|::.:.||.:|:.|
  Fly   644 WYHHMSNGTITFVNNFGR-YDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWS 707

Human   680 LLDVKMINHD---------SEKEDIDAESSFSLNMNF-------SSKRTKFKITTSMQKDTPQEM 728
            |:....|...         |..:|....:.|.:|..|       |.:|.|..:...:|..|.:..
  Fly   708 LVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQ 772

Human   729 EQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQY 793
            ::...::.:.|.:..|.||::|||.||.:.:.||..|:|...:..|.||..|||:.:|.||:.:|
  Fly   773 QEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKY 837

Human   794 IERSQASADEYSYVA 808
            :.|.....:.:.|||
  Fly   838 MRRDDDDINMFIYVA 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL2	XP_011518045.1	Cullin	77..707	CDD:459983	190/746 (25%)
		Cullin_Nedd8	738..798	CDD:463146	24/59 (41%)
Cul5	NP_651665.2	Cullin	17..744	CDD:459983	190/746 (25%)
		Cullin_Nedd8	779..846	CDD:214883	24/66 (36%)