Protein Alignment CUL2 and Cul6

DIOPT Version :10

• Sequence 1: XP_011518045.1
• Gene: CUL2 / 8453
• HGNCID: 2552
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 793
• Identity: 159/793 - (20%)
• Similarity: 307/793 - (38%)
• Gaps: 182/793 - (22%)

Human    64 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSD---------------IYALCVA-- 111
            |:...|:.::.::...|:..|..||          |..|.|               ||..|.|
  Fly     1 MNRVKRISNYFDSMLPLIDNILQVV----------NQIFDDYTSFDGQKLMHLYHLIYKQCAAER 55

Human   112 -YPEPL---GERLYTETKIFLENHVRHLHKRVLESE------EQVLVMYHRYWEEYSKGADYMDC 166
             :..|.   |..||......|...:::: ..|:|::      .:::..|..:|..|.:..:.::.
  Fly    56 NWNNPAQKNGRSLYIVLSDCLMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNL 119

Human   167 LYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAIL--IRMLLRE 229
            ...:.|..::::.:|......|            .|..||:..|::|:.||...||  ||::|.:
  Fly   120 ACYHFNRNWVERERLKGDKETY------------PIYRLAMISWKELVFEPSVTILAAIRLILSQ 172

Human   230 IKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESN 294
            :.                       .:|.|....:.||.:.....|....:|  |:.|  |....
  Fly   173 MP-----------------------REYNKSLEYQVYQVLQSIVELYANDKY--QDVS--LPSRI 210

Human   295 CSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVA----DHLQFLHAECHNIIRQEKKN 355
            ...:.|||:...|               :..:||.|:.:|:    |...||...|  :...|.:|
  Fly   211 DKIFTEKVMDFYK---------------STTLHEFQKIVVSNDYKDFKHFLRYAC--LAMPEIEN 258

Human   356 DMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLF-------VESVLEVHGKF 413
            ......:|.|.::..|    ||             :.|:.::....|       ::..|..|.|.
  Fly   259 GTQFKAILKRYLAARL----QE-------------TRLSGKDYIQAFLGLCRGPLQRALRDHTKL 306

Human   414 VQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRL 478
            .::::.|...:              :|.:  ..:.....||..|.:.|:.|..:  :|..:.|.|
  Fly   307 AEVVDAVCKEE--------------INRK--GQIIDPTRLLVTYANELMTKRQE--SEEAIIDEL 353

Human   479 TSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM 543
            ...:...:::.|:..|...|.:.|..|.|:..|.|...|..|.:.|.:......|..::....|:
  Fly   354 KRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDV 418

Human   544 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTF-----AIPQELEKSVQMF 603
            .....|..:|.:.:.::.  |.||..|:         |.......:|     .:|.||:::.:.|
  Fly   419 DKLRTLKKEFQDHLNSKG--IKLGFDFR---------PKCFKNDGSFENFNLTLPDELQQAWKEF 472

Human   604 ELFY-SQHFSGRKLTWL-HYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDST 666
            .:|| ::....:.:..| :.|.:||:..:.....|:..|:|.|||||:.||..|..:.:||..:.
  Fly   473 RIFYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTAL 537

Human   667 QMNEKELTKTIKSL-----LDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQ 726
            .:..:.|.:.:|.:     ::|..:|:            ..:||:|::::.:......:.:...:
  Fly   538 GVELETLQEALKQIKFLVYIEVNKVNY------------IEINMDFTNRKRRLFCNEPLPRKMRK 590

Human   727 EMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDK 791
            ..|::...:...|...:.||||||||.:|.|.::.||..|..:.:.|..|.:|.|||.::.|:::
  Fly   591 IEEKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVER 655

Human   792 QYIERSQASADEY 804
            :|:||     |.|
  Fly   656 EYLER-----DNY 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL2	XP_011518045.1	Cullin	77..707	CDD:459983	129/681 (19%)
		Cullin_Nedd8	738..798	CDD:463146	24/59 (41%)
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	154/769 (20%)