Protein Alignment CUL2 and Cul4

DIOPT Version :10

• Sequence 1: XP_011518045.1
• Gene: CUL2 / 8453
• HGNCID: 2552
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Alignment Length: 810
• Identity: 229/810 - (28%)
• Similarity: 391/810 - (48%)
• Gaps: 78/810 - (9%)

Human    18 THGDMERKPCDIERKSTGQLIGENGTLLYPDCGDGHAWLFQHYTCTMSLKPRVVD--FDETWNKL 80
            :||::.      ...:|..|:...|.:.....||....:.:::    ..||.:.|  ..:|:.||
  Fly    71 SHGEIR------TASTTSNLLNRMGAIHNSKPGDVKKIVIKNF----KDKPTLPDNYSKDTYVKL 125

Human    81 LTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQ 145
            ...:.|:.:.:.: :.:..:.:..:..:|   ...:..:||.:.|...|.||    ||.::.:|.
  Fly   126 EEAVIAIQLSKPI-KYSLEELYQAVVNMC---SHKMDAQLYAKLKELTEQHV----KRNIKLKEL 182

Human   146 ---------VLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLME 201
                     :|...:.:|..:.:....:..::.|::..::.:|....:
  Fly   183 TGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHS----------------- 230

Human   202 IGELALDMWRKLMVE--PLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLK 264
            |.::.||::|....:  .:|...:..||..|:.:|.|    ..|..|::.|.|     :....|:
  Fly   231 IWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQG----STVDRGLLKSLV-----RMLCDLQ 286

Human   265 FYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHEC 329
            .|...||..||..|.:.||.|:...:||....:|::.|..||.:|..|.|.||..|:...:|:..
  Fly   287 IYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNV 351

Human   330 QQRMVADHL-QFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNL 393
            ::.::|:|| ..|.....:::...:.:|:..:|.||..|..|...:.......|..:|  .|..:
  Fly   352 EKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKG--RTIVI 414

Human   394 TQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYC 458
            ..|...:: |:.:|:...|...::.|....::.|.::|.:|....:|.|..|..    ||:|||.
  Fly   415 DPEKDKSM-VQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPA----ELIAKYV 474

Human   459 DNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINK 523
            |..|:...||.|:.|:|..|...:.:|::|..||||:.||.:.|||||:.|.|.|:|||::|::|
  Fly   475 DMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSK 539

Human   524 LKQACGYEFTSKLHRMYTDMSVSADLNNKFNN--FIKNQDT-VIDLGISFQIYVLQAGAWPLTQA 585
            |||.||..|||||..|:.||.:|.|:|..|..  ...|:|. .:||.:|    :|..|.|| |.|
  Fly   540 LKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVS----ILTMGYWP-TYA 599

Human   586 PSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLA 650
            |:.....||.:... |:|..||.:..|||||.|...|....::..:...|...:|:.:|..|||.
  Fly   600 PTEVTMPPQFINPQ-QIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVLLL 663

Human   651 FNNSETVSYKELQDSTQMNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMNFSSKRTK 713
            ||:...:||:|:..:|.:.:.||.:|::||.  ..::|....:..:|.....|..|..|::|..:
  Fly   664 FNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNEFTNKLFR 728

Human   714 FKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSI 778
            .||.....|:|.:|.:.|...|.:||:..:.||||||||.||.|.||.||.|:.:|......|
  Fly   729 IKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVKP-- 791

Human   779 SMIKKCIEVLIDKQYIERSQASADEYSYVA 808
            :.:||.||.|||:.|:||.:.:.::|:|||
  Fly   792 ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL2	XP_011518045.1	Cullin	77..707	CDD:459983	175/646 (27%)
		Cullin_Nedd8	738..798	CDD:463146	30/59 (51%)
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	175/644 (27%)
		Cullin_Nedd8	753..813	CDD:463146	30/61 (49%)