Protein Alignment CUL2 and Cul1

DIOPT Version :10

• Sequence 1: XP_011518045.1
• Gene: CUL2 / 8453
• HGNCID: 2552
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 785
• Identity: 269/785 - (34%)
• Similarity: 438/785 - (55%)
• Gaps: 67/785 - (8%)

Human    69 RVVDFDETWNKLLTTIKAVVMLE-YVERATWNDRFSDIYALCV---AYP-----------EPLGE 118
            ::|:.|:.|::|:..|..|...| .:.|:.:...::.:|..|.   |.|           :.:|:
  Fly    12 KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGK 76

Human   119 RLYTETKIFLENHVRHL--HKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKL 181
            :||...:.||::::..|  ..:.:..||.:|..|.:.|:.|...:..:|.:..|||..::|:
  Fly    77 KLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKR--- 138

Human   182 TEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHG 246
               :.:.|..|:      .:|..|||..|:..:.:.|...:.:.:|:.|:.:|.|:..|:.::..
  Fly   139 ---ECEEGQKGI------YKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRD 194

Human   247 VINSFVHV---------EQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKV 302
            ||..:|.:         ||.|    |..|::.||:.|:.:|..:|::|:...|..:..::|::.|
  Fly   195 VIECYVELSFNEEDTDAEQQK----LSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHV 255

Human   303 LGRLKDEEIRCR--------KYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMAN 359
            ..||::|..|.|        .|||.::...:...|::.::..||:..|.|..|::..::.:|:..
  Fly   256 ENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKR 320

Human   360 MYVLLRAVSTGLPHMIQELQNHIHDEGLRATS---NLTQENMPTLFVESVLEVHGKFVQLINTVL 421
            ||.|:...|..|..:...|:|||..:|..|.:   .....|.|..:|:::|:||.|:..|:.|..
  Fly   321 MYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAF 385

Human   422 NGDQHFMSALDKALTSVVNYRE---PKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT 483
            |.|..|::|||||....:|...   ..|..|:|||||||||.|||||:|...:.|:||.|...:.
  Fly   386 NNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMV 450

Human   484 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSAD 548
            |||||:|||||||:|::||||||::..|.|.|:|..||:||||.||||:|.||.||:.|:.||.|
  Fly   451 VFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKD 515

Human   549 LNNKFNNFI--KNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHF 611
            ||:.|..::  ||....||.||.    ||.:|:||...  |:.|.:|.|||:||:.|..||:...
  Fly   516 LNSYFKQYLAEKNLTMEIDFGIE----VLSSGSWPFQL--SNNFLLPSELERSVRQFNEFYAARH 574

Human   612 SGRKLTWLHYLCTGEVKMNY---LGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKEL 673
            |||||.||:.:|.||:.||.   ....|....:|:||:|||.||:..:.:.::|||:||..::.|
  Fly   575 SGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENL 639

Human   674 TKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDED 738
            .:.::.||..|::.....:..:..||:..|.:::.:|:.:..|...::.:...|.|.....::||
  Fly   640 IQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEED 704

Human   739 RKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADE 803
            ||:.:|||||||||.||.|.|..||.||::|...||.|.:.:|||||::||:|:|:||.:...|.
  Fly   705 RKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDT 769

Human   804 YSYVA 808
            |||:|
  Fly   770 YSYLA 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL2	XP_011518045.1	Cullin	77..707	CDD:459983	222/674 (33%)
		Cullin_Nedd8	738..798	CDD:463146	35/59 (59%)
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	222/674 (33%)
		Cullin_Nedd8	704..765	CDD:463146	35/60 (58%)