Protein Alignment CUL2 and Cul2

DIOPT Version :10

• Sequence 1: XP_011518045.1
• Gene: CUL2 / 8453
• HGNCID: 2552
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Alignment Length: 761
• Identity: 385/761 - (50%)
• Similarity: 537/761 - (70%)
• Gaps: 24/761 - (3%)

Human    64 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFL 128
            |||||::|:|.:.|.:|....::|:.|..|||:.||..|||:|.||||.|||:.:|||.|||.||
  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFL 65

Human   129 ENHVRH-LHKRVLESEE--------QVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEA 184
            |.||:. |.|:||...|        .:|..|:..|.|||:|..|:..||.|||.|.|||.|:|:.
  Fly    66 EQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDT 130

Human   185 DLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDR---GGEDPNQ-KVIH 245
            :..||....|..|. ||||||.||:||..|:|.|.:.|:|.:|..|..||   |..|.:: ::|:
  Fly   131 ESFYGNLSSDAAEQ-MEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIIN 194

Human   246 GVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEE 310
            |||:|||.|:.|||...||.|||:||.|.|..:|.||..||:.||...:.|:||::|:..|:.|.
  Fly   195 GVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYES 259

Human   311 IRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGL-PHM 374
            .|.:|:||.||..|:..||:::.:.|.|.|:::||..::.:|::.|:.||||:|:.:...| ..:
  Fly   260 RRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSEL 324

Human   375 IQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVV 439
            |....:||..|||:..|.|..||:...|||::|:||.|:.:||..|...|..|:||||||..||:
  Fly   325 ITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVI 389

Human   440 NYREP--KSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARML 502
            | |.|  :..|::.|.:|||||.|||||.  ..|.|::.:||:.||:||||:||||:||||:|:|
  Fly   390 N-RRPTERQPCRSAEYVAKYCDTLLKKSK--TCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLL 451

Human   503 AKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLG 567
            ||||||..|.|||:||.|||:||||||||||:|||||:||:|||.|||||||..:|  |:.:|||
  Fly   452 AKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK--DSNVDLG 514

Human   568 ISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYL 632
            |:..|.|||||||||.......||:|||.|||::|||.:|.:.||||||||||::|.||:|:::|
  Fly   515 INLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHL 579

Human   633 GKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDA 697
            .|.|:..:.|||||::|.|...:::|.:|:|::.|:|::...|.::.:::.|::|..|  |::..
  Fly   580 KKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASS--ENLAG 642

Human   698 ESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNAL 762
            |:...||:::::|||||||::::||:||||:|.|.::||||||::|||||||||||||||:||||
  Fly   643 ETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNAL 707

Human   763 IQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 808
            ||||:|.|:..|.|:|:|||||:|.|||||||||:..|.|||||:|
  Fly   708 IQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL2	XP_011518045.1	Cullin	77..707	CDD:459983	307/645 (48%)
		Cullin_Nedd8	738..798	CDD:463146	46/59 (78%)
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	307/645 (48%)
		Cullin_Nedd8	683..745	CDD:463146	46/61 (75%)