Protein Alignment CUL2 and Cul3

DIOPT Version :10

• Sequence 1: XP_011518045.1
• Gene: CUL2 / 8453
• HGNCID: 2552
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Alignment Length: 838
• Identity: 239/838 - (28%)
• Similarity: 399/838 - (47%)
• Gaps: 113/838 - (13%)

Human    23 ERKPCDIERKSTGQLIGENGTLLYPDCGDGHAWLFQH----YTCTMSLKPRVVDFDET-WNKLLT 82
            |::..:|.||             ||      .||.::    :..:|..|     :.|| |..|..
  Fly   158 EKRFKEIARK-------------YP------LWLPEYKRRAFNASMDEK-----YVETIWASLKN 198

Human    83 TIKAVVMLEYVERATWNDRFSDIYALCVAYPEPL---GERLYTETKIFLENHVRH-LHKRVLES- 142
            .|:     |..::......|..:|.  .||...|   |.|||...:..:..|:.| :...|||:
  Fly   199 AIQ-----EIQKKNNSGLSFEQLYR--NAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEAL 256

Human   143 EEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELAL 207
            ....|...::.|.::......:..:..|::..::::.   |.|..|..|.:...:.::...|
  Fly   257 HSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQR---EVDNVYNLGLILFRDQVVRYSE--- 315

Human   208 DMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFES 272
                      :|..|...||..:..:|.||..|...|....:..:.:....:    ..|:|.||.
  Fly   316 ----------IQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSR----TVYEEDFEK 366

Human   273 PFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADH 337
            |||.::..:||.|:.|.|.|:|...|::||..|:.:|..|...||...:..:::...::.::..|
  Fly   367 PFLAQSAAFYKFESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKH 431

Human   338 LQFLHAECHN-----IIRQEKKNDMANMYVLL-RAVSTGLPHMIQELQNHIHDEGLRATSNLTQE 396
            ::.: .|..|     :|:..|..|:|..|.|. |....||..:...:..::.::|......  :|
  Fly   432 MRPI-VEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKE--EE 493

Human   397 N---MPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYC 458
            |   .|..||:::|::..:|.|.:......|:.|.:.:.......:|...     |:||.|:.:.
  Fly   494 NGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNN-----KSPEYLSLFI 553

Human   459 DNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINK 523
            |:.|||..|||:|.|:|..|...:.:|:::.:||||:::|...|||||:...|:|.|.|:.||:|
  Fly   554 DDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISK 618

Human   524 LKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSS 588
            ||..||.:|||||..|:.|||||..:.::|.||:.|.:..:. |:...:.:|..|.|| ||..:.
  Fly   619 LKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLG-GVELTVRILTTGFWP-TQTATP 681

Human   589 TFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG-------------------- 633
            ...||....::..:|:.||....|||:||....:.|..:...:.|
  Fly   682 NCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGC 746

Human   634 ------KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVK------MI 686
                  :.::..|:||||.|||.|||.:.::|.::...|.:.|:||.:.::||...|      :.
  Fly   747 GVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVR 811

Human   687 NHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQK-DTPQEMEQTRSAVDEDRKMYLQAAIVRI 750
            |..::.:||:....|.:|..|:||..:.||.|...| ::..|.::||..||||||..::||||||
  Fly   812 NSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRI 876

Human   751 MKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 808
            |||||.|.||.|:.:|.||.::||.||...|||.||.||:::|::||......|:|:|
  Fly   877 MKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL2	XP_011518045.1	Cullin	77..707	CDD:459983	176/675 (26%)
		Cullin_Nedd8	738..798	CDD:463146	34/59 (58%)
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	176/675 (26%)
		Cullin_Nedd8	864..926	CDD:463146	35/61 (57%)