DRSC/TRiP Functional Genomics Resources

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Protein Alignment JPH4 and jph3b

DIOPT Version :10

Sequence 1:NP_115828.2 Gene:JPH4 / 84502 HGNCID:20156 Length:628 Species:Homo sapiens
Sequence 2:NP_001116174.2 Gene:jph3b / 569861 ZFINID:ZDB-GENE-060503-415 Length:791 Species:Danio rerio


Alignment Length:649 Identity:285/649 - (43%)
Similarity:371/649 - (57%) Gaps:100/649 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHW 65
            ||.||:|:|||||.|.||||.|:|||:|:||||..||||:|.|:||||.:|::|.|.|:::||.|
Zfish     1 MSTGGRFNFDDGGSYCGGWEEGKAHGHGICTGPKGQGEYAGSWSHGFEVVGIYTWPSGNTFQGTW 65

Human    66 QQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWES--VSGLRYAGLWKDGFQDGYGTETYSDGGT 128
            .||||.|:|:|.|.:|.|:|||..|.|||.||.||  .|| :|.|.|.:|.||||||||||||||
Zfish    66 AQGKRHGIGIENKGKWVYKGEWTHGFKGRYGVRESTGTSG-KYEGTWNNGLQDGYGTETYSDGGT 129

Human   129 YQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPL-----PLPGDEG---- 184
            |||||..|.||||||||||||..||::|||.|||::|..|:.......|     |:.|..|    
Zfish   130 YQGQWVGGMRHGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHSNGTALLSGDRAPVAGVGGSGVL 194

Human   185 --GSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSG--LRAGGRRSSLG---SKRG 242
              ||||. |||||||....:|:...::|:     |.|||| ||||  ||....:|||.   ||:.
Zfish   195 VVGSPAV-SRGGFVLTAHSEAELLKNKKK-----GLFRRS-LLSGLKLRKSESKSSLASQRSKQS 252

Human   243 SLRSE--------VSSEVGSTGPPGSEASGPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQR 299
            |.|||        .:|::.||...|......|.....  ::.:.||.|||||:.|:|:|.|||:|
Zfish   253 SFRSEAGMSTVSSAASDINSTISLGEGEGELPVGDDD--VDATTTESYAGEWKNDKRTGCGVSRR 315

Human   300 SNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAV 364
            |:||:|:||||||:|||||.||.|||::||||||:|.||.|.| ::|:|  ||..|::|||||||
Zfish   316 SDGLQYQGEWLGNKRHGYGCTTFPDGTKEEGKYKQNILVSGKR-KNLIP--LRASKIREKVDRAV 377

Human   365 EGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPG----- 424
            |.|.:|...|:|:.|||.:|.|.|..||.||::.|:||.|..|:|::.|::..|..:..|     
Zfish   378 ESADKAADIAKQKAEIALSRTAHARGKADAATAAAQKAQEECRLARITAKEFSPSFQHRGNRVEC 442

Human   425 RRPR-QDSEGSDTEPLDE---DSPGVYENGLTPSEGSPELPSSPASSRQPWRPPACRSPLPPGGD 485
            :||: |:|..:|.|.:..   ||..:|..|.||.:.:|::  ||..|| |..||  |||......
Zfish   443 QRPKQQNSSENDVEVISSGTADSTELYMKGSTPPDLTPDV--SPTPSR-PSTPP--RSPTTKSSH 502

Human   486 Q---GPFSSPKAWPEEWGGAGAQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEG 547
            :   ..|....|..||.||.           .|.:..|:|.|...|    ||.......||....
Zfish   503 RTKNARFLRQTAVDEERGGT-----------QEIQVLMEGRGGGGG----GGSGGGGDYLRANSW 552

Human   548 EDEEPLPPLRAPAGTEPEPIAMLVLRGSSSRGPDAGCLTEELGEPAATERPAQPGAANPLVVGA 611
            .:|      :.|:            ||.||||...|           :.|...|...:.:.|||
Zfish   553 SEE------KRPS------------RGGSSRGGSRG-----------SSRSTTPSVQDEVRVGA 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JPH4NP_115828.2 COG4642 <4..143 CDD:443680 90/140 (64%)
MORN 1 50..72 11/21 (52%)
MORN 2 74..95 11/20 (55%)
MORN 3 96..117 11/22 (50%)
MORN 4 118..140 18/21 (86%)
MORN 5 141..163 16/21 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 158..214 23/66 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..276 14/55 (25%)
COG4642 <281..>336 CDD:443680 38/54 (70%)
MORN 7 317..339 15/21 (71%)
MORN 8 340..362 10/21 (48%)
PRK07003 <369..>606 CDD:235906 71/248 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..602 50/198 (25%)
jph3bNP_001116174.2 None

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