DRSC/TRiP Functional Genomics Resources

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Protein Alignment JPH4 and Als2

DIOPT Version :10

Sequence 1:NP_115828.2 Gene:JPH4 / 84502 HGNCID:20156 Length:628 Species:Homo sapiens
Sequence 2:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster


Alignment Length:413 Identity:105/413 - (25%)
Similarity:151/413 - (36%) Gaps:116/413 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGK 69
            ||......|.|||.::.||.||:||         |.   .|..:|      |....|:|::.:|.
  Fly   779 GKMVIPTTGLYVGNFKGGRFHGHGV---------YE---MHCKDS------PESEVYEGNFCEGL 825

Human    70 REGLGVERKSRWTYRGEWLGGLKGRSGVWES-VSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQW 133
            ..|.||.|.:|:.|.||:....:...||.|. |||.:|.|::.|..:.|.|:...:.|..::|.:
  Fly   826 FHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFEGSF 890

Human   134 QAGKRHGYGVR--QSVPYHQAAL-LRSPRRTSLDSGHSDPPTPPPPLPLPGDE-GGSPASGSRGG 194
            ......|.||.  ::..|::..| |..|      :|..:...|      .||. |||.|.|: |.
  Fly   891 SGDDLTGSGVAVFENDYYYEGELTLLGP------NGRGEYYMP------SGDACGGSGAMGT-GE 942

Human   195 F----VLAGP---GDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRR-----SSLG--------- 238
            |    .|.|.   |...|.....|..|.      .|:|:      ||     ||||         
  Fly   943 FDDTCELIGNKMFGQLSGTWDTVRIQAG------ELVLN------RRFPKYPSSLGRQVVDHNRK 995

Human   239 --SKRGSLRSEVSSEVGSTGPPGSEASGPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQRSN 301
              |...:..|::::...||...|...|                   ||..|...:.....:|..|
  Fly   996 WRSLFNNFESDLANCTASTSSSGGNQS-------------------AGTLRKSSKPTLSTAQIWN 1041

Human   302 GLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEG 366
            .:   ..::..:|...|  |:|      |.|..|.|:.       |||       .:|....:..
  Fly  1042 CI---AVYMSKQRAREG--TKP------GNYFNNILLS-------LPL-------PQKTSSPLAK 1081

Human   367 ARRAVSAARQRQEIAAARAADAL 389
            ||...||..:.| ..||.|.|.|
  Fly  1082 ARTTTSALSKLQ-TEAASALDFL 1103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JPH4NP_115828.2 COG4642 <4..143 CDD:443680 41/138 (30%)
MORN 1 50..72 4/21 (19%)
MORN 2 74..95 7/20 (35%)
MORN 3 96..117 9/21 (43%)
MORN 4 118..140 3/21 (14%)
MORN 5 141..163 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 158..214 17/63 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..276 12/60 (20%)
COG4642 <281..>336 CDD:443680 11/54 (20%)
MORN 7 317..339 7/21 (33%)
MORN 8 340..362 4/21 (19%)
PRK07003 <369..>606 CDD:235906 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..602
Als2NP_649347.1 ATS1 <238..>367 CDD:444065
PH-like 616..715 CDD:473070
COG4642 <745..890 CDD:443680 40/128 (31%)
PLN03185 835..>962 CDD:215619 39/139 (28%)
VPS9 1373..1479 CDD:460489
Blue background indicates that the domain is not in the aligned region.

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