Protein Alignment JPH4 and jph-1

DIOPT Version :10

• Sequence 1: NP_115828.2
• Gene: JPH4 / 84502
• HGNCID: 20156
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_492193.2
• Gene: jph-1 / 266843
• WormBaseID: WBGene00002179
• Length: 747
• Species: Caenorhabditis elegans
• Alignment Length: 771
• Identity: 255/771 - (33%)
• Similarity: 356/771 - (46%)
• Gaps: 181/771 - (23%)

Human     4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQG 68
            ||:|||||||.||||||.|:|||:||||||.|:|||:|.|.:|||..||:|.|.|::|||.||.|
 Worm     3 GGRFDFDDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQNG 67

Human    69 KREGLGVERKSRWTYRGEWLGGLKGRSGVWESV-SGLRYAGLWKDGFQDGYGTETYSDGGTYQGQ 132
            ||.|||:|::.||.|:|||..|.|||.||.:|. |..||.|.|..||.||||||.|.|.|:||||
 Worm    68 KRHGLGIEQRGRWLYKGEWTQGYKGRYGVRQSANSQARYQGTWSAGFHDGYGTEIYVDSGSYQGQ 132

Human   133 WQAGKRHGYGVRQSVPYHQAALLRSPRR-----TSLDSGHSDPPTPPPPLPLPGDEGGSPASGSR 192
            |..|.|||||:|:|..|.:||..||..:     |||.||..:......      :.........|
 Worm   133 WLRGMRHGYGIRKSTTYEKAAKFRSKSQTHASLTSLRSGRVEEENAAE------EHRHKEGLSGR 191

Human   193 GGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLR------AGGRRSSLGSKRGSLRSEVSSE 251
            |||||.  .::.....|:|:.:......:..||||||      .|.....:.|..|||||.
 Worm   192 GGFVLR--ANSSAPQRRRRSLSERSLAVKRTLLSGLRIKKQHSTGDIHQRVASMTGSLRSS---- 250

Human   252 VGSTGPPGSEAS-------GPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEW 309
             |||....||.|       .|...|    :|.|:.|.|.|||:.|.||||||.:||:||:|:|||
 Worm   251 -GSTMSCTSEDSLHHHGLQQPEEEA----VEESSIETYMGEWKNDMRSGFGVCERSDGLKYQGEW 310

Human   310 LGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAA 374
            ..|.:.|||.||..||::|||:||.|.|:...|.:.:  :.:|..|.:||:::|:..|.||.|.|
 Worm   311 ANNAKCGYGVTTFKDGTKEEGRYKNNILIASSRRKGV--IFMRASKFREKLEQALGAASRAASIA 373

Human   375 RQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPG-RRPRQDSEGSDTEP 438
            :|:.:|||:|.:.|..::..||.:|.:|.:.:.:|::.|:...|..:.|| ||..:|:.|.::..
 Worm   374 QQKADIAASRTSTARERSEQASFIARQANDDSEVARIHAKQFDPSFKQPGTRRLLKDNNGGESFG 438

Human   439 LD------------------------------ED-SP--GVYENGLTPSEGSPEL---------- 460
            .|                              || :|  ..|.|.:.|:..:..:
 Worm   439 TDLSDAISYSRHLSQTHSKQHSFEQTLSVDMAEDMTPPSKAYHNHVMPNSNTNHVNFMPQYGYSD 503

Human   461 PSS----PASSR---QPWRP---PACRS---------PL---------PPGGDQGPFSSPKAWPE 497
            |:|    |.:|:   ||..|   |:..|         ||         .||.......:|.....
 Worm   504 PNSQLQTPINSQDLLQPHIPNIDPSIPSVSIVQDDEKPLILQPQTNISQPGPSNLSTQAPNVMSS 568

Human   498 EWG-----------GAGAQAEE---------LAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSL 542
            .:.           ..|||.::         :...:..:.....|...|.   .|....|.:|.:
 Worm   569 RFSLSDDHYDQYVMAGGAQQQQKLRRNRPSLMRQADVNESCAASGLNRRS---TLASARDRNGDV 630

Human   543 RE----------------EEGEDEEPLPPLRAPAGTEPEPIAMLVLRGSSSRGPDAGCLTEEL-- 589
            ..                .:|::...||.|     .|.|...:.:.|..::|  .||...:|:
 Worm   631 NHPGAIGATHAAKLTAATSDGDNMGSLPNL-----AELETQGVRLRREEAAR--LAGQRRQEVLR 688

Human   590 -GEPAATERPAQPGAANPL----------------VVGAVALLDLSLAFLFSQLLT 628
             .|.||..|      ||||                :...:|:.::||..||..|||
 Worm   689 ENEEAALLR------ANPLRHFLQPAFRAWLVRWRIPILLAIANISLLMLFYHLLT 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JPH4	NP_115828.2	COG4642	<4..143	CDD:443680	90/139 (65%)
		MORN 1	50..72		13/21 (62%)
		MORN 2	74..95		11/20 (55%)
		MORN 3	96..117		10/21 (48%)
		MORN 4	118..140		14/21 (67%)
		MORN 5	141..163		10/26 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..214		13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..276		15/51 (29%)
		COG4642	<281..>336	CDD:443680	32/54 (59%)
		MORN 7	317..339		13/21 (62%)
		MORN 8	340..362		5/21 (24%)
		PRK07003	<369..>606	CDD:235906	68/347 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..602		51/297 (17%)
jph-1	NP_492193.2	COG4642	<2..145	CDD:443680	91/141 (65%)
		MORN	283..303	CDD:308220	13/19 (68%)
		MORN	306..328	CDD:308220	12/21 (57%)