DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment JPH4 and jph4

DIOPT Version :10

Sequence 1:NP_115828.2 Gene:JPH4 / 84502 HGNCID:20156 Length:628 Species:Homo sapiens
Sequence 2:XP_002941565.1 Gene:jph4 / 100490043 XenbaseID:XB-GENE-995670 Length:586 Species:Xenopus tropicalis


Alignment Length:659 Identity:326/659 - (49%)
Similarity:386/659 - (58%) Gaps:104/659 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHW 65
            |..||.|.|.|||||:|.|:.|||||||||.||..||||||.|::|||||||:|.|.|::|:|:|
 Frog     1 MFSGGTFGFSDGGCYMGDWQDGRAHGYGVCKGPTRQGEYSGLWSNGFESLGVYTWPSGNTYRGYW 65

Human    66 QQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQ 130
            .||||.|||.|.|.||.|||||..|||||.||.||:||.:|.|||.||.|||||.||||||||||
 Frog    66 DQGKRNGLGEEHKGRWLYRGEWTHGLKGRLGVRESLSGAKYEGLWTDGQQDGYGVETYSDGGTYQ 130

Human   131 GQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLP--LPGDEGGSPASGSRG 193
            ||||:||||||||||||||||||||||||..:|.|....|.|..|.:|  ||    |||||||||
 Frog   131 GQWQSGKRHGYGVRQSVPYHQAALLRSPRTPTLSSLPHSPDTHSPTVPSLLP----GSPASGSRG 191

Human   194 GFVL----AGP---GDADGASSRKRTPAAGGFFRRSLLLSGLR----AGGRRSSLG--SKRGSLR 245
            ||||    .||   |...|...:||:    .||.|||:|||.|    :..:..|.|  |:|.|||
 Frog   192 GFVLKVRGVGPESHGPGSGGKPKKRS----FFFSRSLILSGFRLHRGSDNKTPSSGRDSQRSSLR 252

Human   246 SEVSSEVGSTGPPGSEASGPPAAA------PPALIEGSATEVYAGEWRADRRSGFGVSQRSNGLR 304
            ||.....||.|...|:.....:.|      |.|..|   ||:||||||:|||:|:|||:|||||.
 Frog   253 SETRGAGGSLGSSASQDGSSASVADTDSELPIAAWE---TEIYAGEWRSDRRTGYGVSRRSNGLC 314

Human   305 YEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARR 369
            ||||||.||||||||||.|||||||||||.| ::..|:|:||.|  |||||.:|||:||||.|||
 Frog   315 YEGEWLRNRRHGYGRTTFPDGSREEGKYKMN-ILTSGKVKSLFP--LRRGKGREKVERAVEAARR 376

Human   370 AVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSEGS 434
            |...|||:||:|.|.||||.|:|.|||..|::|:||:|.|::::|||:.:||.|.....||.|.:
 Frog   377 AEGTARQKQEMAVASAADARLQADAASVAAQQALEASRAAQILSQDLEELLETPSSLCVQDGEEN 441

Human   435 DTE---PLDEDSPGVYENGLTPSEGSPELPSSPASSRQPWRPPA--C-----RSPLPPGGDQGPF 489
            ..|   |.....|.:..:|...|:|:|| ||.|.|  .|..||.  |     .:|.||       
 Frog   442 IAEESIPWLRQCPELSHDGTPLSDGTPE-PSLPPS--HPDTPPGFNCTQHREATPCPP------- 496

Human   490 SSPKAWPEEWGGAGAQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEEPLP 554
                          .|.||....|.|..|.:                        .|...|:.||
 Frog   497 --------------IQEEEDNSTEVETPAHL------------------------PEHSQEQMLP 523

Human   555 PLRAPAGTEPEPIAMLVLRGSSSRGPDAGCLTEELGEPAATERPAQPGAANPLVVGAVALLDLSL 619
            ....|.|.. .||:.:...|....|        |:.:|....|  ....|:||||..|..||:||
 Frog   524 EFNPPMGLN-NPISSIDSVGEVDLG--------EIVKPPQQIR--MQTDADPLVVAIVLFLDVSL 577

Human   620 AFLFSQLLT 628
            |||.|..||
 Frog   578 AFLISYFLT 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JPH4NP_115828.2 COG4642 <4..143 CDD:443680 100/138 (72%)
MORN 1 50..72 13/21 (62%)
MORN 2 74..95 14/20 (70%)
MORN 3 96..117 13/20 (65%)
MORN 4 118..140 19/21 (90%)
MORN 5 141..163 19/21 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 158..214 29/64 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..276 16/52 (31%)
COG4642 <281..>336 CDD:443680 45/54 (83%)
MORN 7 317..339 17/21 (81%)
MORN 8 340..362 13/21 (62%)
PRK07003 <369..>606 CDD:235906 72/246 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..602 46/196 (23%)
jph4XP_002941565.1 COG4642 <4..143 CDD:443680 100/138 (72%)
PLN03185 290..>342 CDD:215619 43/51 (84%)
Alanine_zipper 370..425 CDD:432118 32/54 (59%)

Return to query results.
Submit another query.