Protein Alignment JPH4 and jph1a

DIOPT Version :10

• Sequence 1: NP_115828.2
• Gene: JPH4 / 84502
• HGNCID: 20156
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_001159728.1
• Gene: jph1a / 100147894
• ZFINID: ZDB-GENE-040724-233
• Length: 683
• Species: Danio rerio
• Alignment Length: 722
• Identity: 280/722 - (38%)
• Similarity: 358/722 - (49%)
• Gaps: 138/722 - (19%)

Human     4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQG 68
            ||:|||||||.|.||||.|:|||:|:||||..||||||.|:||||.:||:|.|.|::|||:|.||
Zfish     3 GGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSHGFEVVGVYTWPSGNTYQGYWSQG 67

Human    69 KREGLGVERKSRWTYRGEWLGGLKGRSGVWESV-SGLRYAGLWKDGFQDGYGTETYSDGGTYQGQ 132
            ||.|||||.|.:|.|||||..|.|||.||.:|. :..||.|.|.:|.|||||.|||.|.||||||
Zfish    68 KRHGLGVETKGKWLYRGEWSHGFKGRYGVRQSTNTPARYDGTWSNGLQDGYGVETYGDSGTYQGQ 132

Human   133 WQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHS--------DPPTPPPPLPLPGDEGGSPAS 189
            |..|.||||||||||||..|.::|||.||||.|..|        ....|..|:
Zfish   133 WMGGMRHGYGVRQSVPYGMATIIRSPLRTSLASLRSVQSNGAVLQDTVPDTPV------------ 185

Human   190 GSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLL---LSGLRAGGRRSSLGSKRGSLRSEV--- 248
            ||||||||....|.:..:.:|:     |.|||..|   |..||....::|:.|||.|.||:.
Zfish   186 GSRGGFVLNFHSDTEVVTGKKK-----GLFRRGSLFGSLRQLRKSDSKTSISSKRSSARSDATMS 245

Human   249 ---SSEVGSTGPPGSEASGPPAAAP-PALIEGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEW 309
               ||:..||...| |...|....| ...::.:.||.|.|||:.|:|:|||||:|||||:|||||
Zfish   246 RISSSDANSTISYG-EGEVPDDYTPMEDHVDATTTESYMGEWKNDKRNGFGVSERSNGLKYEGEW 309

Human   310 LGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAA 374
            :.|:|||||.|..|||::||||||.|.||.|.| :.|:|  |:..|.|||||||||||||:.:.|
Zfish   310 MNNKRHGYGCTIFPDGTKEEGKYKNNVLVRGIR-KQLIP--LKNHKTKEKVDRAVEGARRSAAIA 371

Human   375 RQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSEGSDTEPL 439
            |.:.|||.:|.:.|..|:.||...|..|.:.:.:|:.:|.:|.|....||....:.......|.:
Zfish   372 RTKVEIAVSRTSHARTKSEAADQAALAACQESDLARAVACELSPSFHQPGLEYIKQKFSEPVEEI 436

Human   440 DEDSP----------GVYENGLTPSEGSPELPS-------------SPASSRQPWR--------- 472
            .|::|          ..|..|.|||....:.|:             :|:.||:..:
Zfish   437 KEEAPKEEEKKSSGSPFYRRGTTPSHSPAQSPTPSPPRTSQKSQAQNPSISRKISKDNSVTARKI 501

Human   473 -----------------------------PPACRSPLPPG------GDQGPFSSPKAWPEEWGGA 502
                                         ||....|.||.      .|..|...|||.......|
Zfish   502 SRDSTSVARKISKEERASIVAEITKVSVPPPPLPPPPPPAVQTIKLQDVPPPKPPKALEPVAKPA 566

Human   503 GAQAEEL--AGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEEP---------LPPL 556
            |....:|  |.:....:...|.|.|                   ||.|||||         :||.
Zfish   567 GTGNGQLHTAYHSYYVKPVKQLPPP-------------------EEPEDEEPEITQSSLARMPPP 612

Human   557 RAPAGTEPEPIAMLVLRGSSSRGPDAGCLTEELGEPAATERPAQPGAANPLVVGAVALLDLSLAF 621
            .....| |.|...:.:|...|..|.:...|::.......|...:....|.::|..|.||::.||.
Zfish   613 PKTLNT-PTPKPEVKIRKQESIKPKSLAETKKASLDLVEEATVEESGPNSILVAMVMLLNIGLAI 676

Human   622 LFSQLLT 628
            :|...||
Zfish   677 IFVHFLT 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JPH4	NP_115828.2	COG4642	<4..143	CDD:443680	92/139 (66%)
		MORN 1	50..72		13/21 (62%)
		MORN 2	74..95		13/20 (65%)
		MORN 3	96..117		9/21 (43%)
		MORN 4	118..140		15/21 (71%)
		MORN 5	141..163		15/21 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..214		19/63 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..276		15/51 (29%)
		COG4642	<281..>336	CDD:443680	37/54 (69%)
		MORN 7	317..339		14/21 (67%)
		MORN 8	340..362		10/21 (48%)
		PRK07003	<369..>606	CDD:235906	65/314 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..602		50/264 (19%)
jph1a	NP_001159728.1	COG4642	<3..143	CDD:443680	92/139 (66%)
		PLN03185	38..>389	CDD:215619	187/371 (50%)