DRSC/TRiP Functional Genomics Resources

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Protein Alignment CUL4B and Cul5

DIOPT Version :10

Sequence 1:NP_003579.3 Gene:CUL4B / 8450 HGNCID:2555 Length:913 Species:Homo sapiens
Sequence 2:NP_651665.2 Gene:Cul5 / 43434 FlyBaseID:FBgn0288875 Length:852 Species:Drosophila melanogaster


Alignment Length:914 Identity:216/914 - (23%)
Similarity:382/914 - (41%) Gaps:243/914 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    61 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDTL 125
            |||.|||::|       .::|.:||      .:|:.:.::.|.|.:                   
  Fly   121 SSSGSSSSAS-------VSASGAST------SAAAAAAATSCSGQA------------------- 153

Human   126 EFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSK 190
                       ..|.:|:|::..|:||......:.|...||.|:...|:|...||::.|      
  Fly   154 -----------GKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSSTS------ 201

Human   191 PGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISAN 255
              ::||              |.|:::                                       
  Fly   202 --TSKK--------------NPTEDS--------------------------------------- 211

Human   256 LYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSM 320
                              ..|:..|||          |..|           :|.|..:.||.|.
  Fly   212 ------------------PVRKLMLDS----------WNKH-----------IFHDIKHRLQESA 237

Human   321 LPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLL----RSLLSMLSD---- 377
            :.                              ::..||||:|.|..|:    .|.:::.|:    
  Fly   238 MK------------------------------IVHAERNGDAYDAQLVVGVRESYVNLSSNAEDK 272

Human   378 LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIA 442
            |:||:::||..:|:.|...|..:..:..||..|..|:.:.:.:|.||..|...||:.::...|..
  Fly   273 LEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTY 337

Human   443 TVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQV--LLQQWIEYIKAFG--- 502
            |:...|:.:||.:|:.: ...|:.:...:.|:|:::|..||..||.|  ::.....:|.:.|   
  Fly   338 TLVNVLIVDHLNSIIAE-CPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLAD 401

Human   503 ---STIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKR--------- 555
               ::.||..:.:| .|:.||:..:|...::...|..:.:|:.|...||:|.:|..         
  Fly   402 MLSASEVITQDSEK-YVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPT 465

Human   556 ------------PNKPAELIAKYVDSKLRAG--NKEATDEELEKMLDKIMIIFRFIYGKDVFEAF 606
                        .:|..||:|.|.|..||..  :|..|.|:::..|..::::.:::..||||..:
  Fly   466 SIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRY 530

Human   607 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--AAFTSKLEGMFKDMELSKDIMIQFKQYMQNQ 669
            :|..|.:||::|.||..:.|:.::..|: |.|  |.:.::|..||:|:::|:|:..||:..:...
  Fly   531 HKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRH 594

Human   670 NVPGNIELTVNILTMGYWPTYVP-MEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLK 733
            :.     :.:.||..|.|..... :.|.||.|:.......:.||..|||||||||...:.:..:.
  Fly   595 DA-----INIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTIT 654

Human   734 AEFKEGKKELQVSLFQTLVLLMFN--EGEEFSLEEIKQATGIEDGELRRTLQSLACG---KARVL 793
            .....|:.:|.|:.||..||..:|  :.::.|.|.::.||.:.|.||||||.||...   |.::|
  Fly   655 FVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQIL 719

Human   794 AKNPKG----KDIEDGDKFICNDDFK-----HKLFRIKIN---QIQMKETVEEQASTTERVFQDR 846
            ...|..    ||..:...|..|.:|.     ....|.|:|   ::|: .|...|....:.:.|.|
  Fly   720 LMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQL-STERSQQEDNQSIVQLR 783

Human   847 QYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPAD--LKKRIESLIDRDYMERDKENPNQY 909
            ..:...||::|||:||.:::..|..|:.:.||....|:.  :|:::|.||:..||.||.::.|.:
  Fly   784 ILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMF 848

Human   910 NYIA 913
            .|:|
  Fly   849 IYVA 852

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CUL4BNP_003579.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..100 11/38 (29%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:19801544 55..58
Cullin 217..814 CDD:459983 152/647 (23%)
Cullin_Nedd8 842..907 CDD:214883 22/66 (33%)
Cul5NP_651665.2 Cullin 17..744 CDD:459983 184/803 (23%)
Cullin_Nedd8 779..846 CDD:214883 22/66 (33%)
Blue background indicates that the domain is not in the aligned region.

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