Protein Alignment CUL4B and Cul4

DIOPT Version :10

• Sequence 1: NP_003579.3
• Gene: CUL4B / 8450
• HGNCID: 2555
• Length: 913
• Species: Homo sapiens
• Sequence 2: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Alignment Length: 820
• Identity: 507/820 - (61%)
• Similarity: 627/820 - (76%)
• Gaps: 15/820 - (1%)

Human   108 AASSHVPIQKKLRFEDTLEFVGFDAKMAEESSSSSSSSSP-----------TAATSQQQQLKNKS 161
            ||..:.|:......|:| |.:....|.||..:.:::::|.           .:|::..::|.|.|
  Fly     3 AAKKYKPMDTTELHENT-ENIAACLKKAENVAPTAAAASSVGRSAFAAQNMNSASTNGERLPNFS 66

Human   162 ILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEA 226
            .|..|...:..|:..:.....:.:..|||||..||:|||||||||.||:||:.:|:.||:|||.|
  Fly    67 KLGGSHGEIRTASTTSNLLNRMGAIHNSKPGDVKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIA 131

Human   227 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQI--HQFREDSLDSVLFLKKI 289
            ||.|..|||:||||||||.|:||:|:.|.||.:|:::.|.|:|..|  .:....|:|.::.|:||
  Fly   132 IQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKI 196

Human   290 DRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLI 354
            :..|.:.|:||||||||||::|||||||||.:.|||||||:|||.|...:..||.:|:||:|.||
  Fly   197 NHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLI 261

Human   355 ERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNK 419
            |:||.|..:||.||:||:.||.|||||..|||::||:.||:||.||.|:.|||.||||||.||||
  Fly   262 EKERQGSTVDRGLLKSLVRMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNK 326

Human   420 RLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVR 484
            ||.||.:||..|||.:|:..||..|||:||.||||:||||||::||::||:.||:|||.|.|||:
  Fly   327 RLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVK 391

Human   485 GGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFE 549
            .|...|...:..:||..|.||||:|||||:|||:|||||||:|.|:..||..||||.|:::||||
  Fly   392 NGTSELCGNFNGFIKKKGRTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFE 456

Human   550 TFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKR 614
            .|||:|.||||||||||||.|||:|||..|||||||.|||||::||||:||||||||||||||||
  Fly   457 FFINQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKR 521

Human   615 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQY-MQNQNVPGNIELT 678
            ||||||||||:|||||||||.|||..|||||||||||||||:||.|.|:.: :.|.....|::|.
  Fly   522 LLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLC 586

Human   679 VNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKEL 743
            |:||||||||||.|.||.:||:.:..|:||..|||.||||||||||.|||:|:|:|:|..|.|||
  Fly   587 VSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKEL 651

Human   744 QVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKF 808
            .|||||.||||:||:....|.|||..||.||||||||||||||||:|||:.|.|||::|.|||:|
  Fly   652 LVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQF 716

Human   809 ICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEV 873
            ..|::|.:|||||||||||||||.|||.:|.||||||||||||||||||||||||||||||::|:
  Fly   717 DFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITEL 781

Human   874 YNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 913
            :|||.|||||||||||||||||||||||||:|.|||||:|
  Fly   782 FNQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL4B	NP_003579.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19801544	55..58
		Cullin	217..814	CDD:459983	383/599 (64%)
		Cullin_Nedd8	842..907	CDD:214883	58/64 (91%)
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	383/597 (64%)
		Cullin_Nedd8	753..813	CDD:463146	54/59 (92%)