Protein Alignment CUL4B and Cul1

DIOPT Version :10

• Sequence 1: NP_003579.3
• Gene: CUL4B / 8450
• HGNCID: 2555
• Length: 913
• Species: Homo sapiens
• Sequence 2: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 767
• Identity: 241/767 - (31%)
• Similarity: 383/767 - (49%)
• Gaps: 76/767 - (9%)

Human   214 DETWQKLKEAV-EAIQNSTSI-KYNLEELYQAVENLCSYKISA------------------NLYK 258
            |:.|.:|.|.: :..::..|: :......|..|.:.|: .:||                  .||.
  Fly    17 DDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCT-SVSAAPSGRSSGKTGGAQLVGKKLYD 80

Human   259 QLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ-----N 318
            :|.|..:.::...:.:|:..|.:.|| |.:..:.|:::.....::..|..:|:|.:|.:     .
  Fly    81 RLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQ 144

Human   319 SMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD------ 377
            ..:..|:.:.|..::.|:.  |.:.......:|..||.||.|:.|:|||:|.::....:
  Fly   145 KGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEE 207

Human   378 --------LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRL------ 428
                    |.:|:.:||.:|:.:|:..|..|....:....|.|||.||..|||||..|:
  Fly   208 DTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSK 272

Human   429 --ITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVL- 490
              ::||.:||...|.:|.|:.|:.:|| .|......|||:.:|..||..:|.|.:.....:..|
  Fly   273 NGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLK 336

Human   491 -------LQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAF 548
                   |.|..|.|....:|...|  ..||.||.:||...|.:.::...|..:..|:.|:.:|.
  Fly   337 SILENHILHQGTEAIAKCCTTDAAN--DPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKAC 399

Human   549 ETFINKR-------PNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF 606
            ..|||..       .:|..||:|||.|..|:..:|...|:|||..|:::|::|::|..||||:.:
  Fly   400 GKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKY 464

Human   607 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNV 671
            |.|.|||||:...|||.|||..|:||||..||..:|.||:.||:|:.:|||:...||||:..:|:
  Fly   465 YSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNL 529

Human   672 PGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQW--QSTLGHCVLKA 734
            ...|:..:.:|:.|.||..:.....||.|:.:....|..||..:||||||.|  |...|..::..
  Fly   530 TMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNV 594

Human   735 EFKEGKK-ELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPK 798
            ....... .||.|.||..|||.||:...|::::::..|..:...|.:.||.|.  ||:||..:..
  Fly   595 NRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTSSDN 657

Human   799 GKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKT 863
            ...:..........|:|:|..||.|||....|...||.:..:.:.:||:..|.|||||||||||.
  Fly   658 ENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKR 722

Human   864 LSHNLLVSEVYNQL--KFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 913
            |:|..|:|||.|||  :|..|...:||.|:.||:::|:||.:.:.:.|:|:|
  Fly   723 LNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL4B	NP_003579.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19801544	55..58
		Cullin	217..814	CDD:459983	193/661 (29%)
		Cullin_Nedd8	842..907	CDD:214883	33/66 (50%)
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	193/661 (29%)
		Cullin_Nedd8	704..765	CDD:463146	33/60 (55%)