Protein Alignment CUL4B and Cul3

DIOPT Version :10

• Sequence 1: NP_003579.3
• Gene: CUL4B / 8450
• HGNCID: 2555
• Length: 913
• Species: Homo sapiens
• Sequence 2: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Alignment Length: 948
• Identity: 324/948 - (34%)
• Similarity: 503/948 - (53%)
• Gaps: 109/948 - (11%)

Human    33 AAAQEVRSATDGNT-STTPPTSAKKRKLNSSSSSSS----NSSNEREDFDSTSSSSSTPPLQPRD 92
            |.:.....||.||. |..|...|::..|...:.|.:    |:|:.::...|.:.      |..:.
  Fly    29 AGSNNFNGATVGNVDSAVPCRIARQNVLGQQARSMNINVPNASSMQQHQQSQNR------LSAQG 87

Human    93 SASPSTSSFCLGVS---VAASSHVPIQKKLRFEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQ 154
            .||.|..|:.|..|   |.|.:.:.....|                    :.:..|.|..|.:..
  Fly    88 LASASRRSYHLAASGGRVRADNRINTNHPL--------------------TPTPLSMPVPAPAAP 132

Human   155 QQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIK------NFKDK---PKLPE 210
            ..:|.::...:|           ..||:.|:.|.|.....|::..|      .:|.:   ..:.|
  Fly   133 AVVKTETSATTS-----------GPSTSASASAESTEKRFKEIARKYPLWLPEYKRRAFNASMDE 186

Human   211 NYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQF 275
            .|.:..|..||.|::.||...:...:.|:||:...|:..:|....||..||::..:|::   |:.
  Fly   187 KYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLE---HKV 248

Human   276 REDSLDSV--LFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIIS 338
            |.|.|:::  .||.|:::.|.:|...|:|||.|.:::||.||.|.. :.:::::||.|||..::.
  Fly   249 RADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQRE-VDNVYNLGLILFRDQVVR 312

Human   339 DQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QIYQDSFEQRFLEETNRLYA 398
            ..::|....:.:|.::..||:||||:...:::..|||..|     .:|::.||:.||.::...|.
  Fly   313 YSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYK 377

Human   399 AEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQ---KG 460
            .|.|..:.|.....|:..|..|:.||:.|...|||:.|:..::..||::|:.:|:..|::   .|
  Fly   378 FESQNFLAENNAGVYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSG 442

Human   461 LNNLLDENRIQDLSLLYQLFSRVR-GGVQVLLQQWIEYIKAFGSTIVINPEKDK----TMVQELL 520
            :..::..::.:||:..|:||||:: .|::|:......|::..|..:|...|...    |.||.||
  Fly   443 VVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLL 507

Human   521 DFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEK 585
            |.||:.|..:...|..:..|.|.:...||.|:|.. ||..|.::.::|.||:.|.|..:::|:|.
  Fly   508 DLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLN-NKSPEYLSLFIDDKLKKGGKGMSEQEIES 571

Human   586 MLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 650
            :|||.|::|||:..|||||.:||..||||||:.||.|.|.||:|:||||.|||..||||||||||
  Fly   572 ILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFK 636

Human   651 DMELSKDIMIQFKQYMQNQNVP-GNIELTVNILTMGYWPTYVPM-EVHLPPEMVKLQEIFKTFYL 713
            ||.:|..||.:||.::.|.|:. |.:||||.|||.|:|||.... ..::|....:..:|||.|||
  Fly   637 DMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYL 701

Human   714 GKHSGRKLQWQSTLGHCVLKAEF-----KEGKKE---------------------LQVSLFQTLV 752
            .|||||:|..|..:|...:.|.|     .|.:|:                     ||||.:|..|
  Fly   702 NKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCV 766

Human   753 LLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGK--ARVLAKN--PKGKDIEDGDKFICNDD 813
            ||:||..:..:.::|.|.|.|.:.||.|.||||:.||  .|:|.:|  .|.||||..|:|..||.
  Fly   767 LLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDA 831

Human   814 FKHKLFRIKINQIQMK-ETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQL 877
            |..|..|:||..:..| |:..|:..|..:|.:||:::|:||||||||.||.|:||||||:|.:||
  Fly   832 FNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQL 896

Human   878 K--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 913
            |  |...|..:|||||.||:|:|::|..|:...|||:|
  Fly   897 KSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUL4B	NP_003579.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		17/71 (24%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19801544	55..58		0/2 (0%)
		Cullin	217..814	CDD:459983	235/643 (37%)
		Cullin_Nedd8	842..907	CDD:214883	38/66 (58%)
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	235/643 (37%)
		Cullin_Nedd8	864..926	CDD:463146	36/61 (59%)