DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DHX16 and l(2)37Cb

DIOPT Version :9

Sequence 1:	NP_003578.2	Gene:	DHX16 / 8449	HGNCID:	2739	Length:	1041	Species:	Homo sapiens
Sequence 2:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	901	Identity:	590/901 - (65%)
Similarity:	741/901 - (82%)	Gaps:	19/901 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   141 SEKGKKKTGGSKQQTEKPESEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLERS-DKKA 204
            |.|.:|:|..|....|:|:||:|      .||:||:|||.||.|:::||.||||||::.: .::|
  Fly     2 SGKNRKRTASSSSSGEEPDSEEE------SRLKDLQERDEFASRLKKRDDDRTRNVVDSTGGRRA 60

Human   205 YEEAQKRLKMAEEDRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEFLFGDVELSRHERQE 269
            .|||.||||:..|||..:||.||.:|||:||.||:.:|:.:|||::.|:|:||.:..|::.|::|
  Fly    61 IEEATKRLKLEHEDRDKIVPHLRLQSRRQYLEKRKDDKVAELEADILDDEYLFDESVLTKREKEE 125

Human   270 LKYKRRVRDLAREYRAAGEQEKLEATNRYHMPKE-TRGQPARAVDLVEEESGAPGEEQRRWEEAR 333
            .:||:::.::|:|:..|.|.|:::   ||:||:: .:|:.:..|: |:|....|..||::||..:
  Fly   126 REYKKQLLNIAKEHEKARELERIQ---RYNMPQDLKKGERSEYVE-VDEFEKQPNSEQKKWEAEQ 186

Human   334 LGAASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSA--PPTSTQAQQKE-SIQAV 395
            |.:|...|||:||.::| :|:|:|:::  |:|::|..|.|..|.|:  .|..|:.::|. ::...
  Fly   187 LASARFHFGAKDAKAEE-EYELLLDDQ--IDFIQALTLDGSREKSSSRQPELTEKERKRLTLDET 248

Human   396 RRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMS 460
            ||||||:||:|:|:||:..|||||||||||||||||:||||.|.|:|.....|.|||||||||||
  Fly   249 RRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMS 313

Human   461 VAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHER 525
            ||||||.|||||||||||||||||||||:||:|:|||||.|.||||||||||||||:::||||||
  Fly   314 VAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHER 378

Human   526 TLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEAD 590
            ||||||||||:||:||||||||:|::|||:|..:||.||||||:|||||||:|||||||||||||
  Fly   379 TLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEAD 443

Human   591 YLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDM 655
            |::||.|||||||.|||.||||||||||:|||...|:|.||.:|||||||||:|:|:||||||||
  Fly   444 YIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDM 508

Human   656 QARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASAN 720
            ||:||:||||.||||::|||||||||||:.||||:||||.||.::|.|||||||.|.|.||||||
  Fly   509 QAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASAN 573

Human   721 QRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPP 785
            ||||||||.|.||||||||||||:||||:.|||||||.:|||.||:||:|||:||:|||||||||
  Fly   574 QRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPP 638

Human   786 YETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVN 850
            :|||:||||||||||||||.||||..||:|||.|||||:.||:||||||.||||::|:|||||||
  Fly   639 HETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVN 703

Human   851 NSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVR 915
            ::||||||||::|||.||.||....||||.||.||.||||:.||:|||||||:|:|||:||||||
  Fly   704 SAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVR 768

Human   916 EQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSG-YRTVKQQQTVFIHPNSSLFEQ 979
            |||.||::|||:.:.||..:.:.||||.|||||||.|||::.| |:|:|..|||.|||||||||:
  Fly   769 EQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSLFEE 833

Human   980 QPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAKKMPKKIGK 1035
            .|||:||||||.|:||:||||:||||.|||||||||||||||||...|||||..|:
  Fly   834 LPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKELEDSTNKKMPKVAGR 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..207		29/66 (44%)
		PTZ00121	<148..376	CDD:173412	94/229 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..391		7/22 (32%)
		HrpA	390..1028	CDD:224557	482/639 (75%)
		DEAH box	520..523		2/2 (100%)
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	476/644 (74%)
		DEXDc	269..408	CDD:238005	114/138 (83%)
		HELICc	491..581	CDD:197757	70/89 (79%)
		HA2	651..735	CDD:214852	60/83 (72%)
		OB_NTP_bind	770..869	CDD:285018	66/98 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152952
Domainoid	1	1.000	200	1.000	Domainoid score	I3041
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2658
Inparanoid	1	1.050	1193	1.000	Inparanoid score	I192
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto90176
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R178
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800