DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fgfr3 and btl

DIOPT Version :9

Sequence 1:	XP_006251452.1	Gene:	Fgfr3 / 84489	RGDID:	620714	Length:	804	Species:	Rattus norvegicus
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	307/847 - (36%)
Similarity:	423/847 - (49%)	Gaps:	121/847 - (14%)

- Green bases have known domain annotations that are detailed below.

  Rat    32 RAAEVPGPEPSQQEQVAFGSGDTVELSCHPPGGAPTGPTLWAKDG-------------------V 77
            |...||..:|......:...||.|.:.|.....|......|...|                   |
  Fly   235 RKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPV 299

  Rat    78 GLVASHRILVGPQRLQVLNATHEDAGVYSC--QQRLTRRVLCHF----------SVRVTDA---- 126
            .:......:..||.|::.|...||.|.|.|  :.::.|.|...:          :||.|..
  Fly   300 DVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVA 364

  Rat   127 ---PSSGDDEDGEDVAED--------TGAPYWTRP-ERMDKKLLAVPAANTVRFRCPAAGNPTPS 179
               |::...||.:|..|:        .|.|.:.:. :|:...|    :.|||...||..|.  .:
  Fly   365 SPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSL----SGNTVNLACPVYGK--AN 423

  Rat   180 ISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSP 244
            |:|.|:.|....|.   |:.:: :.|:|........|.|.|.|.|.|.:|.|:..:::.:.:|:.
  Fly   424 ITWTKDKKPLNREL---GVYVQ-KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTR 484

  Rat   245 HRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISE 309
            ..||:.  :|.|||..:...:...|.||||..|.:.|.:.|..|.|..|         |||...:
  Fly   485 SAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDG---------LKSVEIQ 538

  Rat   310 NVEADAR-----LRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQAAEEELMEVDEAGSVY 369
            |:.....     |.|.||:....|.|.|.|::.:|.:..:.:|||..|....|          :|
  Fly   539 NLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLE----------IY 593

  Rat   370 AGVLSYGVGF--------FLFILVVAAVT--LCRLRSPPKKGLGSPTVHK-VSRFPLKRQVTVSL 423
            |.:.::.:||        .||:|..|.:|  |.|||......|...|||: ..:..:.|......
  Fly   594 ALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEG 658

  Rat   424 ESNSSMNSNTPLVRIARL--------SSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGC 480
            ...||.:...|::||.:.        :.|..|. ...:|.|.|.|..||:.|.:|:||..||||.
  Fly   659 SGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPA-QGFNEYEFPLDSNWEIPRQQLSLGSILGEGA 722

  Rat   481 FGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 545
            ||:||||||.|:.:........|||||:|::.||.|::.||.|||:|||||||.|||||||.|:|
  Fly   723 FGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQ 787

  Rat   546 GGPLYVLVEYAAKGNLREFLRARRPPGMD-------YSFDACRLPEEQLTCKDLVSCAYQVARGM 603
            ||||:|:||||..|||::||:..||....       |..|...:..:.|..|:|...|:|:||||
  Fly   788 GGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGM 852

  Rat   604 EYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRV 668
            |||||::|||||||||||||::..||||||||||||:.:.:||:|.||||||:||||||:|.::.
  Fly   853 EYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKK 917

  Rat   669 YTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAV 732
            |..||||||:|||||||.|.|..|||.| ..|||:..|..|.||:|||.|:.::|::||:|||..
  Fly   918 YDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFE 982

  Rat   733 PSQRPTFKQLVEDLDRILTVTST---DEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPP 794
            ...||||.:|||..|.||...|:   |.|||||:|.       .:||.||...||...|......
  Fly   983 SCARPTFAELVESFDGILQQASSNPNDAYLDLSMPM-------LETPPSSGDEDDGSDTETFRET 1040

  Rat   795 GP 796
            .|
  Fly  1041 SP 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fgfr3	XP_006251452.1	IGc2	51..108	CDD:197706	17/77 (22%)
		IG	52..123	CDD:214652	20/101 (20%)
		Ig2_FGFR	155..239	CDD:143265	23/83 (28%)
		IG_like	254..349	CDD:214653	29/99 (29%)
		Ig3_FGFR	262..350	CDD:143175	26/92 (28%)
		PTKc_FGFR3	457..790	CDD:173652	186/343 (54%)
		Pkinase_Tyr	470..746	CDD:285015	163/283 (58%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	17/88 (19%)
		Ig	258..340	CDD:143165	16/81 (20%)
		I-set	394..479	CDD:254352	25/94 (27%)
		IGc2	408..469	CDD:197706	20/66 (30%)
		IG_like	492..583	CDD:214653	29/99 (29%)
		Ig	507..583	CDD:299845	25/84 (30%)
		PKc_like	700..1000	CDD:304357	169/299 (57%)
		TyrKc	712..996	CDD:197581	163/283 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1150
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1477
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm9075
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770