DRSC/TRiP Functional Genomics Resources

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Protein Alignment DOC2A and PsGEF

DIOPT Version :10

Sequence 1:NP_003577.2 Gene:DOC2A / 8448 HGNCID:2985 Length:400 Species:Homo sapiens
Sequence 2:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster


Alignment Length:545 Identity:110/545 - (20%)
Similarity:170/545 - (31%) Gaps:198/545 - (36%)


- Green bases have known domain annotations that are detailed below.


Human     2 RGRR--------GDRMTINIQEHMAINVCPGP-----IRPIRQISDYFPRGPGPEGGGGGGGEAP 53
            ||||        ||..    :|:..::....|     :..::.:|:.  .|..|:......|..|
  Fly    21 RGRRRGVGVPGVGDAN----KENFGVHFMSSPFGNASLIALQDLSNV--HGKSPQRRSFSEGSGP 79

Human    54 AHLVPLALA---PPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKG 115
            ....|...|   .|....||...|| :::.|....|.|....|  |.:.:.|...:.|:      
  Fly    80 RQATPQLAALRCLPRTTGGAVALED-SQLSSSRMGDTTLDRML--DAIIESARKEVRCT------ 135

Human   116 LKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNE------------DLTYSGITDD 168
                            ..||||    ...|.|.....|..|:|            .|....:...
  Fly   136 ----------------KTLPGA----GATTSTTILADNAEWSETSVHEMEVRTPTHLKRQRVVRR 180

Human   169 DITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICL--------------ERQV-- 217
            ...||...|......:....|       || :|.||.|:    ||              |:||  
  Fly   181 KNPHKTTTINQTQSHQAKKLE-------PL-QLVPSTKR----CLSFSSSSASSDLDEDEQQVAK 233

Human   218 --PLAS-----PSSMSAALRGISCYLKELEQAEQGQGLLE--ERGRILLSLSYSSRRRGLLVGIL 273
              .|||     ||..:.....||.     ..:..|...:|  :||.|.:|:::.::.:.|.|.::
  Fly   234 RSSLASPTTTPPSHCTTTTSSISS-----SSSSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVI 293

Human   274 RCAHLAAM--DVNGYSDPYVKTYLR-----PDVDKKSK--------HKTCVKKKTLNPEFNEEFF 323
            ||..|...  ..||..:.|||..|.     |.....|.        .:|.|.:.:..|.|::.|.
  Fly   294 RCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQRFN 358

Human   324 YEIEL-STLATKTLEVTVWDYD-------------------------------------IGKSND 350
            ::|.. ...|.:.|::.||..|                                     ..|.::
  Fly   359 FQISSGEETAGQYLQLAVWHRDRHLNSVPVTQSEWQARVKSGTERRTAERLAKLENAGNEAKRSE 423

Human   351 FIG--------------GVSLG-----------PGAR--------GEARKHWSDCL-----QQPD 377
            |:|              |||.|           |.:|        |:.:|..::..     ||.|
  Fly   424 FLGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDD 488

Human   378 AALERWH--TLTSELPPAAGALSSA 400
            :..|...  |:|.:.|.|.|:.|.:
  Fly   489 SPAEMAAAVTVTPQKPVATGSGSGS 513

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DOC2ANP_003577.2 Interaction with UNC13D and DYNLT1. /evidence=ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9804756 1..89 22/102 (22%)
C2A_Rabphilin_Doc2 90..213 CDD:176000 24/134 (18%)
Interaction with UNC13D. /evidence=ECO:0000269|PubMed:18354201 215..400 60/288 (21%)
C2B_Rabphilin_Doc2 254..386 CDD:176030 41/224 (18%)
PsGEFNP_996333.4 DUF4799 <99..209 CDD:318308 28/146 (19%)
C2 286..>381 CDD:425499 23/94 (24%)
PDZ_canonical 645..716 CDD:483948
RhoGEF 835..1007 CDD:470622
PRK12323 <2304..>2415 CDD:481241
Blue background indicates that the domain is not in the aligned region.

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