Protein Alignment MEGF10 and drpr

DIOPT Version :10

• Sequence 1: XP_016865476.1
• Gene: MEGF10 / 84466
• HGNCID: 29634
• Length: 1195
• Species: Homo sapiens
• Sequence 2: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Alignment Length: 1152
• Identity: 401/1152 - (34%)
• Similarity: 546/1152 - (47%)
• Gaps: 146/1152 - (12%)

Human    58 ISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWF 122
            :.|.:||:.:.|      ..|...:|:.||:|...|.|:|.|..:....|.:...|.|.....
  Fly     4 VILIACLAQLVL------AQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP-- 60

Human   123 KCTRHRVSYRTAYRHGEKTMYRRK--SQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGW 185
            :|:.:|:.:|...:  .||:.:.:  ..||.|:..|...|||||::.|.|||||:|..|:|:.|:
  Fly    61 RCSTYRIKHRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGY 123

Human   186 GGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRC 250
            ||..|...|....:|.:|:.:|.|.|.|:|.|.:|.|.||.|:.|.||.|.|.:|.:|.:|.::|
  Fly   124 GGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKC 188

Human   251 QCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWM 315
            :|:||..|.||:|||:|.||:||..|:..||.||||.||:|.|||||.|.|...||.|.|..||.
  Fly   189 RCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWT 253

Human   316 GTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQ 380
            |.||...||.|.:|..|.:.|:|:.|..|...||||.|.|||.||||.|||.:.|||..|:.||.
  Fly   254 GDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCD 318

Human   381 CVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPG 445
            |.|...|...:|.|:|..|:.|.:|..|:|....||:.|::.|.|.:|:|..|||.:|.|.|..|
  Fly   319 CANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIG 383

Human   446 WSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSR 510
            ||...|...|:...||..|:..|:|:|||.|..|.|.|.||||::|..|...|..||:|.:|:.|
  Fly   384 WSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALR 448

Human   511 CGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGW 575
            |.|:|.|.|.|..|.|.|.|||..:.|...|....:|..|...|.|.|..|||..:|:||||.||
  Fly   449 CDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGW 513

Human   576 RGEKCELPCQDGTYGLNCAERCDC--SHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSL 638
            .||:||..|..|.:|.:||::|.|  :::..|..|.|.|.|...|.||||::.|..|.:|.||..
  Fly   514 TGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDK 578

Human   639 PCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCL 703
            .|.|.|.:||.||.|.|.|:.|:.|..|...|.|||||..|.:.||:.:|.:..|.||||...|.
  Fly   579 VCRCLNNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCR 643

Human   704 PGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCI 768
            .|:.|..|...||:|.:|..|...|.|.:.|.||.:...|||.|||.||:|::.||...:|..|.
  Fly   644 TGYIGLTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCA 708

Human   769 HTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRT 833
            ..|.|.:...|...||.|.|..||:|..|.:.||.||||:.|...|.|.:.....|.:..|.||:
  Fly   709 QRCRCVHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRS 773

Human   834 GFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLS 898
            |:.|.:|::...|       ::|.|...||                                  |
  Fly   774 GYTGDNCDELIAS-------QRIADQSENS----------------------------------S 797

Human   899 RTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVNADYTI 963
            |.|.||.           ::::.|....:.|:||.||.:....::.:..|.||
  Fly   798 RASVALT-----------LVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYT------------ 839

Human   964 SGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLKNVNPGKRGPV 1028
            ..|.|.|...|   |.|.||.|....:....|: |.|.:|      ||
  Fly   840 HDTNPPSWPPN---HNFDNPVYGMQAETRLLPN-NMRSKM------NN----------------- 877

Human  1029 GDCTGTLPADWKHGGYLNELGAFG-----LDRSYMGKSLK-DLGKNSEYNSSNCSLSSSENPYAT 1087
            .|...|:..|  :|...|..|..|     .:...:.|:|. |......||.|    ...|:.|..
  Fly   878 FDQRSTMSTD--YGDDCNASGRVGSYSINYNHDLLTKNLNADRTNPIVYNES----LKEEHVYDE 936

Human  1088 I------KDP-----PVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQG 1141
            |      |||     .:|.|: .|..:::...|:....|:....|....|.|..|.:|:......
  Fly   937 IKHKEGYKDPVKIYSKILFPE-DEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMT 1000

Human  1142 VFSNNGRLSQDPYDLPKNSHIPCH---------YDLLPVRDSSSSPK 1179
            |..|.        .||.....|.|         .|.:.....|||||
  Fly  1001 VLLNK--------PLPPTEPEPQHECFDNTNTNLDNVSTASPSSSPK 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEGF10	XP_016865476.1	EMI	86..155	CDD:462204	18/70 (26%)
		EGF_Lam	336..373	CDD:214543	21/36 (58%)
		EGF_CA	597..642	CDD:473889	18/46 (39%)
drpr	NP_001261276.1	EMI	26..92	CDD:462204	18/69 (26%)
		EGF_CA	274..319	CDD:473889	25/44 (57%)
		gliding_CglD	<451..579	CDD:468178	54/127 (43%)
		DSL	567..609	CDD:473190	18/41 (44%)