Protein Alignment MEGF10 and ced-1

DIOPT Version :10

• Sequence 1: XP_016865476.1
• Gene: MEGF10 / 84466
• HGNCID: 29634
• Length: 1195
• Species: Homo sapiens
• Sequence 2: NP_740922.1
• Gene: ced-1 / 173064
• WormBaseID: WBGene00000415
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 1173
• Identity: 373/1173 - (31%)
• Similarity: 535/1173 - (45%)
• Gaps: 215/1173 - (18%)

Human    76 GTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYT-------SCTDILNWFKCTRHRVSYRT 133
            ||..|   :..:||:     ..|:.:.|  ...::.:|       .|.:.|..|:|        |
 Worm    35 GTTEP---QGDHVCT-----VKTIVDDY--ELKKVIHTVVYNDTEQCLNPLTGFQC--------T 81

Human   134 AYRHGEKTMYRRK--------SQCCPGFYESGE-MCVPHCADKCVHGRCIAPNTCQCEPGWGGTN 189
            ..:.|:|..|:|:        .|||.|:|::.: .|:|.|...|..|:||.|..|:|:||:||..
 Worm    82 VEKRGQKASYQRQLVKKEKYVKQCCDGYYQTKDHFCLPDCNPPCKKGKCIEPGKCECDPGYGGKY 146

Human   190 CSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQN 254
            |:|:|....||..|:..|.|:|||.|:|..|.|.|.:||:|.|||..|....:|.:|.:.|.|||
 Worm   147 CASSCSVGTWGLGCSKSCDCENGANCDPELGTCICTSGFQGERCEKPCPDNKWGPNCVKSCPCQN 211

Human   255 GATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVC 319
            |..|:. .|:|.|..|:.|.||.:.|..||.|.:|:..|.||||..|.:..|:|.|.||:.|.:|
 Worm   212 GGKCNK-EGKCVCSDGWGGEFCLNKCEEGKFGAECKFECNCQNGATCDNTNGKCICKSGYHGALC 275

Human   320 GQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCV-- 382
            ...|..|.||..|:|:|.|.|...||:::|:|.|. |:||:.|...|..|.:|:.|.:.|.|.
 Worm   276 ENECSVGFFGSGCTQKCDCLNNQNCDSSSGECKCI-GWTGKHCDIGCSRGRFGLQCKQNCTCPGL 339

Human   383 ----NGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACK 443
                :...|...:|.|.||:|:.|.:|:.|.|....||..|.|.|.|..|||..|.|.:|.|.||
 Worm   340 EFSDSNASCDAKTGQCQCESGYKGPKCDERKCDAEQYGADCSKTCTCVRENTLMCAPNTGFCRCK 404

Human   444 PGWSGLYCNETCSPGFYGEAC--QQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGIN 506
            ||:.|..|...||...||..|  |.:|...:.::|:..||.|.|.||..|.:||.||||..||.|
 Worm   405 PGFYGDNCELACSKDSYGPNCEKQAMCDWNHASECNPETGSCVCKPGRTGKNCSEPCPLDFYGPN 469

Human   507 CSSRCGCKNDAV-CSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCT 570
            |:.:|.|....| |...||.|.|..||.|..|...||:.|:|..|...|:|..|..|:.:.|.||
 Worm   470 CAHQCQCNQRGVGCDGADGKCQCDRGWTGHRCEHHCPADTFGANCEKRCKCPKGIGCDPITGECT 534

Human   571 CAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPN 635
            |..|.:|..|::.|.:|:||..|...|.|.:.. |...||.|.|.||:.|..|.:.|::|::|.:
 Worm   535 CPAGLQGANCDIGCPEGSYGPGCKLHCKCVNGK-CDKETGECTCQPGFFGSDCSTTCSKGKYGES 598

Human   636 CSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHI---T 697
            |.|.|.|.: ||||...|.|.|..|.:|.:|.:.|.|..:|..|.:|.     :..||...   .
 Worm   599 CELSCPCSD-ASCSKQTGKCLCPLGTKGVSCDQKCDPNTFGFLCQETV-----TPSPCASTDPKN 657

Human   698 GLC-DCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPA 761
            |:| .|.||.:|..|...||:|.:|..|..:|:|.:...|:|....|.|.||:.|..||:.||..
 Worm   658 GVCLSCPPGSSGIHCEHNCPAGSYGDGCQQVCSCADGHGCDPTTGECICEPGYHGKTCSEKCPDG 722

Human   762 HWGPNCIHTC-NCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNG-ADCDH 824
            .:|..|...| .|.:|:.|...:|.|.|..|..|..||:.|..||:|..|..:|:|.:. ..|:.
 Worm   723 KYGYGCALDCPKCASGSTCDHINGLCICPAGLEGALCTRPCSAGFWGNGCRQVCRCTSEYKQCNA 787

Human   825 ISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNST--CDHITGTCYCSPGWKGARCDQAG 887
            .:|:|:|..||.|..|::.|..|.||..|.:.|.|...:|  |:.::|.|:|.||:.|..|
 Worm   788 QTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATSSCNRVSGACHCHPGFTGEFC---- 848

Human   888 VIIVGNLNSLSRTST-------ALP----ADSYQIGAIAG------------------------- 916
                   ::|...||       ..|    .|.|:..|..|
 Worm   849 -------HALCPESTFGLKCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEALNGAGRS 906

Human   917 -----IIILVLVVLF----LLALFIIYRHK-QKGKESSMPAVTYTPAMRVVNADYTISGTLPHSN 971
                 ..:|::|.|.    |:|||  ||:| ||.|:..||.|::                  |..
 Worm   907 TGLTWFFVLLIVALCGGLGLIALF--YRNKYQKEKDPDMPTVSF------------------HKA 951

Human   972 GGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLKNVNPGKRGPVGDCTGTLP 1036
            ..|.....|.||.|   ::.:..|   :.|..:...:.|:|
 Worm   952 PNNDEGREFQNPLY---SRQSVFP---DSDAFSSENNGNHQ------------------------ 986

Human  1037 ADWKHGGYLNELGAFGLDRSYM------GKSLKDLGKN---------SEYNSSNCSLSSSE---N 1083
                 ||..|  |...|:...:      |:|....|.|         .|.:||:.|.|:|.   |
 Worm   987 -----GGPPN--GLLTLEEEELENKKIHGRSAAGRGNNDYASLDEVAGEGSSSSASASASRRGLN 1044

Human  1084 PYATIKDPPVLIPKSSECGYVEMK----SPA-------RRDSPYAEINN-----STSANR----- 1127
            .....:.|  |:.:..|..:.|..    |||       ..::|||:|::     ..|||:
 Worm  1045 SSEQSRRP--LLEEHDEEEFDEPHENSISPAHAVTTSNHNENPYADISSPDPVTQNSANKKRAQD 1107

Human  1128 NVY 1130
            |:|
 Worm  1108 NLY 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEGF10	XP_016865476.1	EMI	86..155	CDD:462204	18/83 (22%)
		EGF_Lam	336..373	CDD:214543	14/36 (39%)
		EGF_CA	597..642	CDD:473889	17/44 (39%)
ced-1	NP_740922.1	None