DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEGF11 and eater

DIOPT Version :9

Sequence 1:	NP_001371957.1	Gene:	MEGF11 / 84465	HGNCID:	29635	Length:	1140	Species:	Homo sapiens
Sequence 2:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster

Alignment Length:	1032	Identity:	259/1032 - (25%)
Similarity:	358/1032 - (34%)	Gaps:	334/1032 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    99 CIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVC 163
            |||.|...|.:|.|::|:.|.|..|:.....:..|     .|.|.:.|...||....|  ..|.|
  Fly   124 CIPQCASGCPNGTCITPNNCSCNKGYKLNPTTQVC-----LPTCKDNCAAVNGFCAAP--NRCEC 181

Human   164 AAGF------RGWRCEELCAPGTHGKGCQLP--CQCRH------GASCDP------------RAG 202
            ..||      :.:.|:..|..|.....|:.|  |:|..      ..:|.|            ...
  Fly   182 NPGFIPKPKSKSFECQPKCKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPD 246

Human   203 ECLCAPGYTGV---YCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWT--GAVCAQPC 262
            .|.|..|||.:   .|..:||.|           ||| |.| ....||:|..|:|  ..||...|
  Fly   247 VCQCLTGYTKIGHNVCLAVCPEG-----------CQN-GVC-VAPNECSCNAGYTKLEGVCTPVC 298

Human   263 PPGTFGQNCS--QDCPCHHG--------------GQCDH----VTGQCHCTAGYM---GDRCQEE 304
            ..|.....|:  :.|.|:.|              |.|.:    ..|:|.|..||:   |:.|:..
  Fly   299 KDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYIKGTGNSCKPI 363

Human   305 CPFGSFGFQCS--QHCDCHNG------GQCSP------------TTGACECEPGYK---GPRCQE 346
            |..|.....|.  :.|.|::|      .:|||            ..|.|.|:.||.   |..|:.
  Fly   364 CSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKP 428

Human   347 RLCPEGLHGPGCTLP--CPC----DADNTISCHPV------------TGACTCQPGWS---GHHC 390
             :|.:|.....|..|  |.|    :.|:...|.||            .|.|:|..|:|   |:.|
  Fly   429 -ICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSC 492

Human   391 NESCPVGYYGDGCQLP--CTCQNGAD------CHSITGG------------CTCAPGF---MGEV 432
            ...|..|.....|..|  |:|.:|.:      |..:..|            |:|..|:   .|..
  Fly   493 KPICSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPEKCSCDEGYSKETGNS 557

Human   433 CAVSCAAGTYGPNCSS--ICSCNNG------GTCSPV------------DGSCTCKEGWQ---GL 474
            |...|:.|.....|.:  .||||:|      ..||||            .|.|:|.||:.   |.
  Fly   558 CKPICSNGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGN 622

Human   475 DCTLPCPSGTWGLNCN--ESCTCANG------AACSPI------------DGSCSCTPGW---LG 516
            .|...|..|.....|:  |.|:|.:|      ..|||:            .|.|||..|:   .|
  Fly   623 SCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCIAPGKCSCDEGYSKETG 687

Human   517 DTCELPCPDGTFGLNCS--EHCDCSHADG--------CDPV------------TGHCCCLAGW-- 557
            ::|:..|..|.....|.  |.|.|:  ||        |.||            .|.|.|..|:
  Fly   688 NSCKPICSKGCENGFCDAPEKCSCN--DGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSK 750

Human   558 -TGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFR-------GPLCQRICPPGFY 614
             ||..|...|..|           ||||...:||  .|.|..|:.       .|:|...|..||
  Fly   751 ETGNSCKPICSKG-----------CENGFCEAPE--KCSCNDGYEMDGENRCSPVCSGGCKNGF- 801

Human   615 GHGCAQPCPLCVHSSRPCHHISGICECLPGFS---GALCNQVCAGGYFGQ--DCAQLCSCANNG- 673
               |..|               |.|.|..|:|   |..|..:|:.|....  |..:.||| |:|
  Fly   802 ---CIAP---------------GKCSCDEGYSRETGNSCKPICSKGCENGFCDAPEKCSC-NDGY 847

Human   674 ------TCSPI------------DGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSA 720
                  .|||:            .|.|.|..|: .|:...:|.|       |....|.||. |.:
  Fly   848 EMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGY-SKETEISCAP-------FCKDGCVNGL-CVS 903

Human   721 EDGACHCTPGWTGLFCTQRC--PAAFFG--KDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQ 781
            .| .|.|..|:..:..::.|  .....|  .||.:  .|:|| :|  :.|.|||...:.....|.
  Fly   904 PD-FCKCDDGYIFVEESKSCQLDKELLGDYSDCDK--NCRNG-TC--VEGICTCSKQYKLHRNED 962

Human   782 R----CAPGTFGYGCQQLC--ECMNNSTCDHVTGTCYCSPG---FKGIRCDQAALMMEELNPYTK 837
            .    |.|         :|  ||: |..|: ..|:|.|..|   ..|..|..    |:.|...|.
  Fly   963 DNNLICLP---------ICEPECL-NGLCE-FPGSCVCWDGESPIDGYSCQS----MDSLGSLTG 1012

Human   838 ISPALGAERHSVG---AVTGIMLLLFLIVVLLGLFAWHRR------RQKEKGRDLAP 885
            ...   :|||...   .:..:..:|.:|..:|.::.:.:|      .::|.|...:|
  Fly  1013 HEK---SERHLKWVFITIVSMAFILAIITTMLIIYIFRKRSYHVDKNEREFGVYFSP 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEGF11	NP_001371957.1	EMI	26..93	CDD:400092
		EGF_CA	275..320	CDD:419698	16/67 (24%)
		EGF_CA	362..409	CDD:419698	18/67 (27%)
eater	NP_651533.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810