DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MEGF11 and CG17147

DIOPT Version :9

Sequence 1:	NP_001371957.1	Gene:	MEGF11 / 84465	HGNCID:	29635	Length:	1140	Species:	Homo sapiens
Sequence 2:	NP_001262099.1	Gene:	CG17147 / 40216	FlyBaseID:	FBgn0260393	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	359	Identity:	68/359 - (18%)
Similarity:	106/359 - (29%)	Gaps:	139/359 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   393 SCPVGYYGDGCQL---------PCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSS 448
            |..||.|.:.|:|         |.||.....|:...|                           :
  Fly    22 SASVGEYEELCRLFKNGTKVRKPGTCDQYIQCYDGNG---------------------------T 59

Human   449 ICSCNNGGTCSPVDGSCT---------CKEGWQGLDCTLPCPSGTW---GLNCNESCTCANGAAC 501
            :.:|.:..:.:|..|||.         |....:|||       |.|   ...|::...|.||.
  Fly    60 VLTCPSNQSFNPSKGSCVDTLANSNKYCGNRCEGLD-------GEWVADPTECHKYFYCMNGV-- 115

Human   502 SPIDGSC-----------SCTPGW------LGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTG 549
             |:.|.|           ||..|.      :.:.|||...:..|    ....||::...||....
  Fly   116 -PLAGMCPVGQHFDERSQSCLYGVDSMCVDVNNICELVAENTKF----RNEKDCAYYYECDKTGN 175

Human   550 HCCCLAGWTGIRCDSTCPPGRW----GPNC----SVSCS-------CENGGSCSPEDGSCECAPG 599
            |       ....|..|.....:    ..||    .|.|:       |.:..:.:.:.....|...
  Fly   176 H-------ASKSCTVTSKKREYFDVESGNCVEANKVECTAHSKENVCTSSTTMTFKSDQATCRGY 233

Human   600 FRGPLCQRI------------CPPGFY----GHGCAQPCP-LCVH-------------SSRPCHH 634
            |   :|:.:            ||.|::    ...||.|.. :|.|             ||..||:
  Fly   234 F---VCKALYPVADLDPLWTQCPEGYFFDEDRQLCANPTTVVCTHNRCDGRGTMLVTSSSNNCHN 295

Human   635 ISGICECLPGFSGALCNQVCAGGYFGQDCAQLCS 668
               ...|:.  :..:..:.|...:|..:..:.||
  Fly   296 ---YIRCVD--NKEVTEETCHWDHFFDETVEACS 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEGF11	NP_001371957.1	EMI	26..93	CDD:400092
		EGF_CA	275..320	CDD:419698
		EGF_CA	362..409	CDD:419698	7/24 (29%)
CG17147	NP_001262099.1	ChtBD2	<44..77	CDD:214696	9/59 (15%)
		ChtBD2	89..136	CDD:214696	14/56 (25%)
		CBM_14	278..332	CDD:279884	9/52 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010