DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MEGF11 and CG11674

DIOPT Version :9

Sequence 1:	NP_001371957.1	Gene:	MEGF11 / 84465	HGNCID:	29635	Length:	1140	Species:	Homo sapiens
Sequence 2:	NP_572948.1	Gene:	CG11674 / 32374	FlyBaseID:	FBgn0030551	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	83/393 - (21%)
Similarity:	125/393 - (31%)	Gaps:	105/393 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   586 SCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICEC-LPGFSGAL 649
            |||.:   .:||...||......|.....|.|...||.......:..:.|.|.|.| :|   .|:
  Fly    28 SCSSD---AQCAQFERGRCVDMACICTARGSGERVPCTPLEERLKLTNIIGGACPCPMP---NAI 86

Human   650 CNQ-----VCAGGYFGQDCAQLCSCANNGTCSPIDGSC----QC-----FPGWIGKDCSQACPPG 700
            |:.     .|:.|:...|..:.|..|    ..|:.|||    ||     |...||..|
  Fly    87 CHTRWQQCHCSEGHVSSDDRRRCLPA----VVPVGGSCEFQQQCQRADRFSSCIGNQC------- 140

Human   701 FWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGAS-CDHI 764
                .|.:....|.|...|....:|                  ...||||   .|  ||| |...
  Fly   141 ----LCLNQFEFHEGRCLSVLQSSC------------------LEDKDCG---SC--GASICLTK 178

Human   765 SGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRC-DQAALM 828
            :.:|.|...|...|...:|..|: .||          .||:| :..|..:.|..| || |...:.
  Fly   179 TKRCGCSKNFVHNHNMTKCIKGS-AYG----------DTCEH-SSPCKLNLGADG-RCLDHLCVC 230

Human   829 MEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAM 893
            .....|....:.....|...:.||..:..:....:|..|                        |:
  Fly   231 RSTHYPKRVANEVAKDENDDLDAVNNLERITCAPIVPFG------------------------AL 271

Human   894 RMTSTDYSLSDLSQSSSHAHCFSNSSYHALAC--GGPATSQASTLDRNSPTKLSNKSLDRDTAGW 956
            ....::..:..:.|.::.|     |..|.:.|  |..:.|:...|:.|....:.|.:.:....|:
  Fly   272 CRNDSECRMQPMDQENATA-----SIGHPMVCNWGECSCSKTHRLEDNKCVFVENSATNYQLRGF 331

Human   957 TPY 959
            ..:
  Fly   332 VAF 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEGF11	NP_001371957.1	EMI	26..93	CDD:400092
		EGF_CA	275..320	CDD:419698
		EGF_CA	362..409	CDD:419698
CG11674	NP_572948.1	EB	96..153	CDD:279949	18/71 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910