Protein Alignment MEGF11 and ced-1

DIOPT Version :9

• Sequence 1: NP_001371957.1
• Gene: MEGF11 / 84465
• HGNCID: 29635
• Length: 1140
• Species: Homo sapiens
• Sequence 2: NP_740922.1
• Gene: ced-1 / 173064
• WormBaseID: WBGene00000415
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 1126
• Identity: 383/1126 - (34%)
• Similarity: 531/1126 - (47%)
• Gaps: 149/1126 - (13%)

Human    14 LQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYT-------RCTDILNWFKCTRHRISYK 71
            ||......|:..:||:     ..|:.:.|  ...::.:|       :|.:.|..|:||..:...|
 Worm    31 LQQQGTTEPQGDHVCT-----VKTIVDDY--ELKKVIHTVVYNDTEQCLNPLTGFQCTVEKRGQK 88

Human    72 TAYRRGLRTMYRRRSQCCPGYYESGD-FCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDS 135
            .:|:|.|....:...|||.|||::.| ||:|.|...|..|:|:.|..|.|:||:||..|:|.|..
 Worm    89 ASYQRQLVKKEKYVKQCCDGYYQTKDHFCLPDCNPPCKKGKCIEPGKCECDPGYGGKYCASSCSV 153

Human   136 DHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPR 200
            ..||..||..|.|:|||.|:|..|.|:|.:||:|.|||:.|.....|..|...|.|::|..|: :
 Worm   154 GTWGLGCSKSCDCENGANCDPELGTCICTSGFQGERCEKPCPDNKWGPNCVKSCPCQNGGKCN-K 217

Human   201 AGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPG 265
            .|:|:|:.|:.|.:|...|..|..||.|:..|.||||.||.:..|:|.|..|:.||:|...|..|
 Worm   218 EGKCVCSDGWGGEFCLNKCEEGKFGAECKFECNCQNGATCDNTNGKCICKSGYHGALCENECSVG 282

Human   266 TFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDC------HNGG 324
            .||..|:|.|.|.:...||..:|:|.| .|:.|..|...|..|.||.||.|:|.|      .:..
 Worm   283 FFGSGCTQKCDCLNNQNCDSSSGECKC-IGWTGKHCDIGCSRGRFGLQCKQNCTCPGLEFSDSNA 346

Human   325 QCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHH 389
            .|...||.|:||.|||||:|.||.|....:|..|:..|.|..:||:.|.|.||.|.|:||:.|.:
 Worm   347 SCDAKTGQCQCESGYKGPKCDERKCDAEQYGADCSKTCTCVRENTLMCAPNTGFCRCKPGFYGDN 411

Human   390 CNESCPVGYYGDGC--QLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSC 452
            |..:|....||..|  |..|...:.::|:..||.|.|.||..|:.|:..|....|||||:..|.|
 Worm   412 CELACSKDSYGPNCEKQAMCDWNHASECNPETGSCVCKPGRTGKNCSEPCPLDFYGPNCAHQCQC 476

Human   453 NNGGT-CSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLG 516
            |..|. |...||.|.|..||.|..|...||:.|:|.||.:.|.|..|..|.||.|.|:|..|..|
 Worm   477 NQRGVGCDGADGKCQCDRGWTGHRCEHHCPADTFGANCEKRCKCPKGIGCDPITGECTCPAGLQG 541

Human   517 DTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSC 581
            ..|::.||:|::|..|..||.|.:.. ||..||.|.|..|:.|..|.:||..|::|.:|.:||.|
 Worm   542 ANCDIGCPEGSYGPGCKLHCKCVNGK-CDKETGECTCQPGFFGSDCSTTCSKGKYGESCELSCPC 605

Human   582 ENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQ-----PCPLCVHSSRPCHHISGIC-E 640
            .: .|||.:.|.|.|..|.:|..|.:.|.|..:|..|.:     ||.    |:.|   .:|:| .
 Worm   606 SD-ASCSKQTGKCLCPLGTKGVSCDQKCDPNTFGFLCQETVTPSPCA----STDP---KNGVCLS 662

Human   641 CLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPA 705
            |.||.||..|...|..|.:|..|.|:||||:...|.|..|.|.|.||:.||.||:.||.|.:|..
 Worm   663 CPPGSSGIHCEHNCPAGSYGDGCQQVCSCADGHGCDPTTGECICEPGYHGKTCSEKCPDGKYGYG 727

Human   706 CFHAC-SCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNG-ASCDHISGKC 768
            |...| .|.:|::|...:|.|.|..|..|..||:.|.|.|:|..|.:||:|.:. ..|:..:|:|
 Worm   728 CALDCPKCASGSTCDHINGLCICPAGLEGALCTRPCSAGFWGNGCRQVCRCTSEYKQCNAQTGEC 792

Human   769 TCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNST--CDHVTGTCYCSPGFKG------------ 819
            :|..||.|..|::.|..|.:|..|.:.|:|...:|  |:.|:|.|:|.|||.|
 Worm   793 SCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATSSCNRVSGACHCHPGFTGEFCHALCPESTF 857

Human   820 ------------------------------IRCDQAALMMEELNPYTKISPALGAERHSVGAVTG 854
                                          :.|.:|....|.||         ||     |..||
 Worm   858 GLKCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEALN---------GA-----GRSTG 908

Human   855 IMLLLFLIVVL----LGLFA--WHRRRQKEKGRDLAPRVSYTPA------MRMTSTDYSLSDLSQ 907
            :.....|::|.    |||.|  :..:.||||..|: |.||:..|      ....:..||...:..
 Worm   909 LTWFFVLLIVALCGGLGLIALFYRNKYQKEKDPDM-PTVSFHKAPNNDEGREFQNPLYSRQSVFP 972

Human   908 SSSHAHCFSNSSYHALACGGPATSQASTLDRNSPTKLSNKSL-DRDTAGWTPYSYVNVLD----- 966
            .|. |....|:..|.   |||... ..||:..   :|.||.: .|..||.....|.: ||
 Worm   973 DSD-AFSSENNGNHQ---GGPPNG-LLTLEEE---ELENKKIHGRSAAGRGNNDYAS-LDEVAGE 1028

Human   967 -SHFQISALEARYPPEDFYIELRHLSRPAEPHSPGACGMDRRQNTYIMDKGFKDYMKESVC-SSS 1029
             |....||..:|          |.|:...:...|.....|..:        |.:..:.|:. :.:
 Worm  1029 GSSSSASASASR----------RGLNSSEQSRRPLLEEHDEEE--------FDEPHENSISPAHA 1075

Human  1030 TCSLNSSENPYATIKDPPILT 1050
            ..:.|.:|||||.|..|..:|
 Worm  1076 VTTSNHNENPYADISSPDPVT 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEGF11	NP_001371957.1	EMI	26..93	CDD:400092	18/73 (25%)
		EGF_CA	275..320	CDD:419698	18/44 (41%)
		EGF_CA	362..409	CDD:419698	20/48 (42%)
ced-1	NP_740922.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I8895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13031
Inparanoid	1	1.050	701	1.000	Inparanoid score	I377
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	1	1.000	-	-		FOG0001631
OrthoInspector	1	1.000	-	-		otm15619
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	1	1.100	-	-	O	PTHR24035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5768
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010