Protein Alignment L3MBTL3 and L3mbtl3

DIOPT Version :10

• Sequence 1: XP_006715639.1
• Gene: L3MBTL3 / 84456
• HGNCID: 23035
• Length: 815
• Species: Homo sapiens
• Sequence 2: NP_766375.1
• Gene: L3mbtl3 / 237339
• MGIID: 2143628
• Length: 883
• Species: Mus musculus
• Alignment Length: 918
• Identity: 698/918 - (76%)
• Similarity: 741/918 - (80%)
• Gaps: 138/918 - (15%)

Human     1 MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWM 65
            |||||||||||||||||||||||||||||||||||||||||||||||||:|||:|||||||||||
Mouse     1 MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDESEMESVKKATATTTWM 65

Human    66 VPTAQEAYTGDLAKSLPLFFSSTPMVVTNTYMLMTPKSTSPAPTSPPSSRPVFPPAYWTSPPGCP 130
            |||||:                                   ||||||||||||||||||||||||
Mouse    66 VPTAQD-----------------------------------APTSPPSSRPVFPPAYWTSPPGCP 95

Human   131 TVFSEKTGMPFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEE 195
            ||||||||:|||||:..|.:|||||||||||||.|||||||.|||||||||.||||||:|||..|
Mouse    96 TVFSEKTGVPFRLKEQSKADGLQFCENCCQYGNGDECLSGGKYCSQNCARHAKDKDQKDERDGGE 160

Human   196 DNEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLP 260
            ||:|||||||||||||||||||:|:||||||||||||||.|||||||||||||||||||||||||
Mouse   161 DNDEEDPKCSRKKKPKLSLKADSKDDGEERDDEMENKQDGRILRGSQRARRKRRGDSAVLKQGLP 225

Human   261 PKGKKAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVC 325
            |||||.||||||||||||||||.|||||||||||||||||||||||||||:||::||||||||||
Mouse   226 PKGKKTWCWASYLEEEKAVAVPTKLFKEHQSFPYNKNGFKVGMKLEGVDPDHQAMYCVLTVAEVC 290

Human   326 GYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAP 390
            |||||||||||||||||||||||||||||||||||||||.|||||||||||||:|||||||||||
Mouse   291 GYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLRPPKGYKEEEFNWQSYLKTCKAQAAP 355

Human   391 KSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASS 455
            ||||||||||||||||||||||||.|||:||.||||||||||||||||||||||||||||||::|
Mouse   356 KSLFENQNITVIPSGFRVGMKLEAADKKSPSVICVATVTDMVDNRFLVHFDNWDESYDYWCESNS 420

Human   456 PHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVD 520
            ||||||||||||||||||||||.:||||||||||||||||||||||||||||||||||||||.||
Mouse   421 PHIHPVGWCKEHRRTLITPPGYSHVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEAVD 485

Human   521 KRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPLSPLELM 585
            ||||:||||||||||||||:|||||||::|||||||||||||||||||||||||||.||||.|||
Mouse   486 KRNPLFIRVATVADTDDHRIKVHFDGWSSCYDYWIDADSPDIHPVGWCSKTGHPLQAPLSPAELM 550

Human   586 EASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRLSGE-MPPASPSFPRN 649
            |.||.|||.|.||:|:||||::|:||..|.||||||||||:|:|||||||||: .||.:|||||:
Mouse   551 EPSETGGCPTLGCRGVGHFKKSRYLGTQSGANCPYSEINLSKERIFPDRLSGDTSPPTTPSFPRS 615

Human   650 KRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREEP------------------ 696
            ||.|..|||||||.|::||::.|||.|::.|:|::||.||:..||||
Mouse   616 KRMDTRESSSSPETREKHANNFKEDSEKKKENEVKTSAEAKVVREEPTPSVQQSQPPQQVQQVQH 680

Human   697 ----------------------------------------------------------------- 696
                                                                             
Mouse   681 AQPPQQAQKAPQAQQAQQAQQAQQAPQAPQTPQPQQAPQVQQAQQAPQAQQAQQPQQAQQPQQAP 745

Human   697 -------------------TVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSK 742
                               |.||||||||||||||.|||||||||||||||||||||||||:|||
Mouse   746 PVQQPQQVQQAQPTQQQAQTQQQAQRRSAVFLSFKPPIPCLPLRWEQQSKLLPTVAGIPASRVSK 810

Human   743 WSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAA 807
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   811 WSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAA 875

Human   808 EKNSHNEL 815
            ||||||||
Mouse   876 EKNSHNEL 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L3MBTL3	XP_006715639.1	MBT_L3MBTL3_rpt1	294..394	CDD:439122	94/99 (95%)
		MBT_L3MBTL3_rpt2	401..493	CDD:439125	84/91 (92%)
		MBT_L3MBTL3_rpt3	502..579	CDD:439128	70/76 (92%)
		SAM_Scm-like-3MBT3,4	740..805	CDD:188981	64/64 (100%)
L3mbtl3	NP_766375.1	Interaction with RBPJ. Required for transcription repressor activity on Notch target genes. /evidence=ECO:0000250|UniProtKB:Q96JM7	1..64		60/62 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..223		68/76 (89%)
		MBT 1	232..332		94/99 (95%)
		MBT_L3MBTL3_rpt1	259..359	CDD:439122	94/99 (95%)
		MBT 2	340..439		92/98 (94%)
		MBT_L3MBTL3_rpt2	366..458	CDD:439125	84/91 (92%)
		MBT 3	448..543		89/94 (95%)
		MBT_L3MBTL3_rpt3	467..544	CDD:439128	70/76 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..768		43/172 (25%)
		SAM_Scm-like-3MBT3,4	808..873	CDD:188981	64/64 (100%)