DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment L3MBTL3 and mbtr-1

DIOPT Version :9

Sequence 1:	XP_006715639.1	Gene:	L3MBTL3 / 84456	HGNCID:	23035	Length:	815	Species:	Homo sapiens
Sequence 2:	NP_001122542.1	Gene:	mbtr-1 / 171624	WormBaseID:	WBGene00021661	Length:	564	Species:	Caenorhabditis elegans

Alignment Length:	424	Identity:	94/424 - (22%)
Similarity:	162/424 - (38%)	Gaps:	97/424 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   222 GEERDDEME--NKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEE------EKA 278
            |.::|..|:  ..:.:.:|:..|..:..|||.:..     ||..:..   ...|:|      |..
Worm   166 GLKQDPAMKWLQYRPLSLLKPMQCPKFWRRGSTPA-----PPVPRPT---EEILDEFQAELHENR 222

Human   279 VAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDGYS------ 337
            ::.| |:|.:.:...:..:.|::..::|.::....:...|..:..:.|.|:.:......
Worm   223 ISEP-KIFDQLRHLAHRPSRFRLNQRVELLNYLEPTEIRVARILRILGRRLMVMVTAQDYPEDLP 286

Human   338 -----------DCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQ----TYLK---TC 384
                       :..:|||:..:..:.|||:....|.:....:||.|......    :|.|   |.
Worm   287 SVEAKDRQVQHENVEFWVDESSFFLFPVGFAMINGLRTKATEGYLEHSRRIAEGSGSYHKDDVTF 351

Human   385 KAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKN---PSFICVATV----------------TD 430
            :...|.|.....:.:.::    :||.|.|.:|..:   .|| ||||:                |:
Worm   352 EQLFAGKPDISAEKLNLL----KVGQKFELLDPLSDLRQSF-CVATIRKICKTPGFLIISPDETE 411

Human   431 MVDNRFLVHFDNWDESYDYWCEASSPH-IHPVGWCKEH----RRTLITPPGYPNVKHFSWDKYLE 490
            ..|..|.:|.||              | :||||:.::.    .|...|.||     .|.|:.||:
Worm   412 SDDESFPIHIDN--------------HFMHPVGYAEKFGIKLDRLAGTEPG-----KFKWEGYLK 457

Human   491 ETNSLPAPARAFKVKPP----HGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCY 551
            |..:...|....:..|.    |.|:....||.|.:....:|..|:|.:.....|.:.|.||::.:
Worm   458 EKQAEKIPDEMLRPLPSKERRHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEF 522

Human   552 DYWIDADSPDIHPVGWCS----KTGHPLQPPLSP 581
            ....|.||.|:.|.|||.    |..||:.|...|
Worm   523 SELYDMDSHDLLPAGWCEFFNFKLRHPVLPVNDP 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
L3MBTL3	XP_006715639.1	MBT	271..367	CDD:214723	18/118 (15%)
		MBT	380..474	CDD:214723	28/120 (23%)
		MBT	486..578	CDD:214723	28/99 (28%)
		zf-C2HC	592..619	CDD:279824
		SAM	740..806	CDD:197735
		SAM_Scm-like-3MBT3,4	740..805	CDD:188981
mbtr-1	NP_001122542.1	MBT	75..164	CDD:302657
		MBT	217..326	CDD:214723	16/109 (15%)
		MBT	374..439	CDD:280910	20/79 (25%)
		MBT	453..540	CDD:214723	24/86 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161457469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840