DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DYRK2 and CG7028

DIOPT Version :9

Sequence 1:	NP_006473.2	Gene:	DYRK2 / 8445	HGNCID:	3093	Length:	601	Species:	Homo sapiens
Sequence 2:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	350	Identity:	109/350 - (31%)
Similarity:	175/350 - (50%)	Gaps:	23/350 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   203 YDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQ-HVALKMVRNEKRFHRQAAEE 266
            :||.:|.|.....:.:..||.|....|:|.|..||:..|....| :||:|::||.:..|:....|
  Fly   573 WDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRE 637

Human   267 IRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-NKFQGFSLPLVRKFAH 330
            :.||:.|...|.::..:.:.:..:|..:.|:||.||.|:|||.|::|| .|..|..:..||.:..
  Fly   638 LEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQ 702

Human   331 SILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGS-SCYEHQRVYTYIQSRFYRAPEVI 394
            .:...|..|.|..|:|.|:||:|||:.:.... :|:.|||| |......:..|:.|||||:||:|
  Fly   703 QLFLALKLLKKTGILHADIKPDNILVNENNLI-LKLCDFGSASAISDNEITPYLVSRFYRSPEII 766

Human   395 LGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLG-MPSQKLLDASKRAKNFVSS 458
            ||..|...||.||.||.:.||.||..|..|:.....|...:::.| :|::.:.....|.::|..|
  Fly   767 LGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQS 831

Human   459 KGYPRYCTVTTLSDGS-----VVLNGGRSRRGKLRG----PPESREWGNALKGCDDPLFLDFLKQ 514
            ..: .|..:..|::..     .|:...||.:.:|..    |.:.......||        |.|:.
  Fly   832 CNF-LYHEIDKLTEREKIVVMPVVKPSRSLQQELIADQNLPDDQHRKVTQLK--------DLLEN 887

Human   515 CLEWDPAVRMTPGQALRHPWLRRRL 539
            ....|||.|::..|||.||:::.::
  Fly   888 MFALDPAKRISLNQALVHPFIQEKM 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DYRK2	NP_006473.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PKc_DYRK2_3	156..535	CDD:271126	109/344 (32%)
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:19965871	189..191
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	105/326 (32%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	102/318 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810