DRSC/TRiP Functional Genomics Resources

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Protein Alignment DYRK2 and Dyrk2

DIOPT Version :9

Sequence 1:NP_006473.2 Gene:DYRK2 / 8445 HGNCID:3093 Length:601 Species:Homo sapiens
Sequence 2:NP_001260456.1 Gene:Dyrk2 / 34831 FlyBaseID:FBgn0016930 Length:757 Species:Drosophila melanogaster


Alignment Length:664 Identity:264/664 - (39%)
Similarity:356/664 - (53%) Gaps:130/664 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    18 RGGDSAVRQLQAS----PG-------LGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSK 71
            |.|.:..:.||:.    ||       |......||      |.:.||.|           ..||:
  Fly    25 RNGITGYKLLQSDLVWCPGIQLDNEKLRRDVRLSG------SRLDLPQL-----------CNGSR 72

Human    72 HTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNG---------LTTVGKTGLPVVPERQL 127
            .....:.||.                :|:.||.||..||         .......|.||......
  Fly    73 RLDGHNNHVA----------------ANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTN 121

Human   128 DSIHRRQ-------------GSSTSLKSMEGMGKVKA-TPMTPEQAMKQYMQKLTAFEHHEIFSY 178
            .|....:             |||.:..|..|.|::|. |||||.:.:|::...||..|..|:..|
  Fly   122 SSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVY 186

Human   179 PEIYFLGLNAKK---RQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY 240
            .|:::.|.:|.|   :...|....|.|||||.|:|..:.|||:|:|||:|:||||||||||::|.
  Fly   187 KEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRAL 251

Human   241 DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLS 305
            |||.:.|||:|::||:|||..||..|:.||:.||::|.|.:.||||||:...||.|:|:||||:|
  Fly   252 DHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMS 316

Human   306 MNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG 370
            :|||||||||.:.|||:.|:|:|.:||::||..|:|..|||||||||||||||:|.|.|||||||
  Fly   317 LNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFG 381

Human   371 SSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMI 435
            ||||..:::||||||||||:||||||.:||..|||||||||||||.||:||.|||:|.:||||::
  Fly   382 SSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIM 446

Human   436 ELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 500
            |:||:|.:.|:..::|.:.|..|:..||..|.|.          ||.|      .|.|:...:.|
  Fly   447 EVLGLPPKVLISVARRRRLFFDSRDAPRCITNTK----------GRKR------SPGSKSLAHIL 495

Human   501 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL------RRRLPKPPTGEKTS---------- 549
            . |.|..|:|||::|||||||.||||.:|..|.:|      |.|..:..:...:|          
  Fly   496 H-CQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKSS 559

Human   550 ---------------VKRITESTG------AITSISKLPPPSSSASKLRTN------LAQMTDAN 587
                           |..||.:|.      |.|:.|:..|||.|....::|      ....:|..
  Fly   560 CYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPDIKLSASDKY 624

Human   588 GNIQQRTVLPKLVS 601
            .::|:..|..|:.|
  Fly   625 NSMQKVAVRSKITS 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DYRK2NP_006473.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 2/5 (40%)
PKc_DYRK2_3 156..535 CDD:271126 204/381 (54%)
Nuclear localization signal. /evidence=ECO:0000305|PubMed:19965871 189..191 1/4 (25%)
Dyrk2NP_001260456.1 PKc_DYRK4 186..529 CDD:271127 198/359 (55%)
S_TKc 233..529 CDD:214567 179/312 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 71 1.000 Domainoid score I9448
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162948at33208
OrthoFinder 1 1.000 - - FOG0000895
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100394
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 1 1.000 - - X888
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.750

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