DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF333 and CG3847

DIOPT Version :9

Sequence 1:	NP_115809.1	Gene:	ZNF333 / 84449	HGNCID:	15624	Length:	665	Species:	Homo sapiens
Sequence 2:	NP_572317.2	Gene:	CG3847 / 31577	FlyBaseID:	FBgn0029867	Length:	380	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	105/481 - (21%)
Similarity:	170/481 - (35%)	Gaps:	141/481 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   149 IQRVVIPVPTLGHRNPWVARDSAV-----PARDPAWLQEDKVEEEAMAPGLPTACSQEPVTFADV 208
            ::..::||        .:.:|:.|     |..|...:|||..:|........|....:    .:.
  Fly    11 VKEEIVPV--------LIEQDTEVDPEEEPEEDEEHVQEDDGQETQYTYAYTTGDDDD----TET 63

Human   209 AVVFTPEEWVFLDSTQRSLYRDVMLENYRNLASVADQLCKPNALSYLEERGEQWTTDRGVLSDTC 273
            |||...:             ||     :..|.:..:.:        ::|.|...|....|.:.|.
  Fly    64 AVVTLSD-------------RD-----HEALVNAEEVI--------IDENGHAVTLQELVENSTV 102

Human   274 AEPQCQPQEAIPSQDTFTEILSI--DVKGEQPQPGEKLYKYNELE--KPFNSIEPLFQYQRIHAG 334
            .|      |.|...|....||.|  ::.||:.:..|:|....|:|  ..|.:::.       ..|
  Fly   103 EE------ETIEQGDGTHTILHIVPNIHGEEVEEDEELEDGEEVEHDDEFVTVDH-------EGG 154

Human   335 EASCECQEIRNSFFQSAHLIVPEKIRSGDKSYACNKCEKSFRYSSDLIRH--EKTHTAEKCFDCQ 397
            |...|..|:.:..|:|.                              |.|  :..:...|.|.|.
  Fly   155 ELEVEDDEVGSIVFEST------------------------------IDHAEQDPYGRNKTFYCP 189

Human   398 ECGQAFKYSSNLRRHMRTHTGEKPFECSQCGKTFTRNFNLILHQRNHTGEKPYECKDCGKAFNQP 462
            .||..:..:.:|:.|||.           |           |.|||.......:||.|.|.||..
  Fly   190 NCGNCYSAAGSLKLHMRA-----------C-----------LRQRNEISTDERKCKVCSKVFNSV 232

Human   463 SSLRSHVRTHTGEKPFECSQCGKAFREHSSLKTHLRTHTREKPYECNQCGKPFRTSTHLNVHKRI 527
            :.|:.|:..||||:||.|::|.:.|.|.|....|:.:|..:...|........:
  Fly   233 AYLKEHMMRHTGEQPFRCTRCYRKFVEESKFTAHMESHKHQDKLEAEAVALAAQ----------- 286

Human   528 HTGEKL----YECATCGQ---VLSRLSTLKSHMRTHTGEKPYVCQECGRAFSEPSSLRKHARTHS 585
            |.|:|:    ::||.|.|   |:..:..:|         :.|.|..|...:|...:||:|.:...
  Fly   287 HGGKKVVVKEFQCAFCSQNFTVVFDVGQVK---------RRYACDACRDKYSNAEALRQHKQQVE 342

Human   586 GKKPYACQECGRAFGQSSHLIVHVRT 611
            .|:.::|..|||.|.....|..|:.|
  Fly   343 EKREFSCVRCGRKFVFEGFLQRHLPT 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF333	NP_115809.1	KRAB	4..61	CDD:214630
		KRAB	4..41	CDD:279668
		KRAB	203..263	CDD:214630	8/59 (14%)
		KRAB	203..242	CDD:279668	6/38 (16%)
		COG5048	<228..525	CDD:227381	66/302 (22%)
		C2H2 Zn finger	340..360	CDD:275368	3/19 (16%)
		zf-C2H2	366..388	CDD:278523	2/23 (9%)
		C2H2 Zn finger	368..388	CDD:275368	2/21 (10%)
		zf-C2H2	394..416	CDD:278523	8/21 (38%)
		C2H2 Zn finger	396..416	CDD:275368	7/19 (37%)
		zf-H2C2_2	408..433	CDD:290200	5/24 (21%)
		C2H2 Zn finger	424..444	CDD:275368	4/19 (21%)
		zf-H2C2_2	436..461	CDD:290200	9/24 (38%)
		C2H2 Zn finger	452..472	CDD:275368	8/19 (42%)
		zf-H2C2_2	464..487	CDD:290200	10/22 (45%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		zf-H2C2_2	492..517	CDD:290200	3/24 (13%)
		C2H2 Zn finger	508..528	CDD:275368	0/19 (0%)
		zf-H2C2_2	520..545	CDD:290200	8/31 (26%)
		C2H2 Zn finger	536..556	CDD:275368	6/22 (27%)
		zf-H2C2_2	549..572	CDD:290200	4/22 (18%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		zf-H2C2_2	576..599	CDD:290200	8/22 (36%)
		zf-C2H2	590..612	CDD:278523	8/22 (36%)
		C2H2 Zn finger	592..612	CDD:275368	8/20 (40%)
		zf-C2H2	618..640	CDD:278523
		C2H2 Zn finger	620..640	CDD:275368
CG3847	NP_572317.2	C2H2 Zn finger	188..216	CDD:275368	12/49 (24%)
		C2H2 Zn finger	222..242	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910