DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABLIM2 and Rx

DIOPT Version :9

Sequence 1:	XP_005248071.1	Gene:	ABLIM2 / 84448	HGNCID:	19195	Length:	701	Species:	Homo sapiens
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	100/502 - (19%)
Similarity:	156/502 - (31%)	Gaps:	140/502 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   214 GIRCDSCEKYITGRVLEAGEKHYHPSCALCVRCGQMFAEGEEMYLQGSSIWHPACRQAARTEDRN 278
            |:.||..|..:....|..|.....|...            ||::.|..|..|...:|..:.:.:.
  Fly   428 GVFCDDNEPKLANGQLPGGNYGIRPRSM------------EEVHHQQQSHHHQQQQQQQQQQQQL 480

Human   279 KETRTSSESIISVPASSTSGSPSRVIYAKLGGEILDYRDLAALPKSKAIYDIDRPDMISYSPYIS 343
            ::.:......    .:|.:|:|:....:...||.|               :.|...:::.|...|
  Fly   481 QQQQGFQHDF----RNSGNGNPNGNSNSGDHGERL---------------NADSDSLVNGSCASS 526

Human   344 HSAGDRQSYGESPQLLSPTPTEGDQDDRSYKQCRTSSPSSTGSV--SLGRYTPTSRSPQHYSR-- 404
            .......|..:..::.|.:..||..|:.:.|:.|.:..:.|...  .|.|....|..|..|||
  Fly   527 EDLNQTNSSEQGEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREE 591

Human   405 -------PAGTVSV----------------------------------GTSSC-----LS---LS 420
                   |...|.|                                  |.|..     ||   ||
  Fly   592 LAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLS 656

Human   421 QHPS----PTSVFRHHYIPYFRGSESGRSTPSLSVLS-----DSKPPPSTYQQAPRHFHVPDTGV 476
            ..|.    |.:|:..:..|....:....:..||:.:.     :..|||          ||...|
  Fly   657 ALPGFLSHPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPP----------HVGHGG- 710

Human   477 KDNIYRKPPIYRQHG---PVAQSQISKLSGLVSVLSLVVQEA-GYGKRQTGPSP---------PP 528
             ....:.||....||   |.....:..||.|...||.:...| ..|....|.:|         ||
  Fly   711 -HGQPQPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHATSLGSPHHGVTPLGTPLHSSLPP 774

Human   529 -------AAAARRSDGEDGSLDQDNRKQKSSWLMLK-GDADT----RTNSPDLDTQSLSHSSGTD 581
                   |.::.:|.....||:........|...|. |:||:    |..|.|||..|.|.:.|:.
  Fly   775 SSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSSNPGSS 839

Human   582 RDPLQRMAGDSFHSRFPYSKSDPLP-----GHGKN--GLDQRNANLA 621
               |.:.|..:........:..|.|     |.|.:  ..|.|:.::|
  Fly   840 ---LDKCAASANIELLDVGRDSPPPPPTPTGKGSSTPPTDMRSNSIA 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABLIM2	XP_005248071.1	LIM1_abLIM	29..80	CDD:188713
		LIM2_abLIM	85..140	CDD:188714
		LIM3_abLIM	158..209	CDD:188715
		LIM4_abLIM	217..272	CDD:188716	12/54 (22%)
		AbLIM_anchor	282..665	CDD:292800	87/434 (20%)
		VHP	667..701	CDD:280388
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	11/51 (22%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910