DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABLIM2 and Unc-115a

DIOPT Version :9

Sequence 1:	XP_005248071.1	Gene:	ABLIM2 / 84448	HGNCID:	19195	Length:	701	Species:	Homo sapiens
Sequence 2:	NP_001163573.1	Gene:	Unc-115a / 261629	FlyBaseID:	FBgn0051352	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	856	Identity:	269/856 - (31%)
Similarity:	365/856 - (42%)	Gaps:	236/856 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    27 ILCNTCGNVCKGEVLRVQDKYFHIKCFVCKACGCDLAEGGFFVRQGEYICTLDYQRLYGTRCFSC 91
            |.|..|...|.||||||.|.:||..||.|..|...||.||||.:...|.|..||||||||:|.:|
  Fly    44 IYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANC 108

Human    92 DQFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKECMCQKC--SLPVS---------- 144
            .|::||||||.:|||||..||.|:.|:.||..|.:||..|||.:|::|  ..|||
  Fly   109 QQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGV 173

Human   145 ----------------------VGSSAHLSQGL--RSCGGCGTEIKNGQALVALDKHWHLGCFKC 185
                                  :...|||.:..  ..|.|||..:|.||||||||:.||:.||:|
  Fly   174 SSPAPPAESPTRATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRC 238

Human   186 KSCGKLLNAEYISKDGLPYCEADYHAKFGIRCDSCEKYITGRVLEAGEK-HYHPSCALCVRCGQM 249
            |:|..:||.||:.||.:||||..|...||::|..|.::|:|:||:||:. |:||:||.|.:||..
  Fly   239 KACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDP 303

Human   250 FAEGEEMYLQGSSIWHPACRQA--------------------------ARTEDRNKETRTSSESI 288
            |.:|||||||||:||||.|...                          ..||.....:...||..
  Fly   304 FGDGEEMYLQGSAIWHPRCGPGPSESGIILNGGGGTSSVVGGASNGNFTDTECDRMSSSALSEMY 368

Human   289 ISVPASSTSG---SPSRVIYAKLG-GEIL-DYRDLAALPKSKAIYDIDRPDMISY---SPYISHS 345
            |.....|.:|   |.||..|..:. |.|| :|    ..|.::   ||.|....||   :|:....
  Fly   369 IRSRTPSFNGSLYSSSRKHYRTVSPGLILREY----GRPNAE---DISRIYTYSYLTDAPHYLRK 426

Human   346 AGDRQSYGESPQLLSP---TPTEGDQDDRSYKQCRTSSPSSTGSVSLGRYTPTSRSPQHYSRPAG 407
            ..|  .|.::|  |||   .|:       ||    .::.|:.|||:..|  |.|| |...:|.|.
  Fly   427 PID--PYDKTP--LSPHFHRPS-------SY----ATTASNAGSVAGSR--PPSR-PHSRTRSAM 473

Human   408 TVSVGTSSCLSLSQHPSPTS--------VFRHHYIPYFRGSESGRSTPSLSVLSDSKPPPSTYQQ 464
            .|.|....    |:.|.|.|        :...|| |..:....|.. |.:. ..|...||..|..
  Fly   474 KVLVDAIR----SETPRPKSPGMNNEEPIELSHY-PAAKKPPPGEQ-PKIE-RDDFPAPPYPYTD 531

Human   465 APRHFHVPDT--GV------KDNIYR-KPPIYRQHGPVAQ------SQISKL-SGLVSVLSLVVQ 513
            ..|.....||  ||      .:|:.. ||....::|...|      .|:.|| ||:.|.::..::
  Fly   532 PERRRRYSDTYKGVPASDDEDENVENGKPNGKVKNGEEQQRLQREAEQLEKLNSGIGSAIAKDLK 596

Human   514 E-AGYGK------------RQTGPSPPPAAAARRSD--GEDGSLDQDNRKQKSSWLMLKGDADTR 563
            | |.|.|            |....|..|....|...  |...|.:.|::|
  Fly   597 EHAKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPIGASPSRNLDHQK--------------- 646

Human   564 TNSPDLDTQSLSHSSGTDRDPLQRMAGD--SFHSRFPYSKSDPLPGHG---------KNGL---- 613
               |..:.:....|: :.|..|.:..|:  |:::...| :|.|.||:|         :||.
  Fly   647 ---PFYEDEMFDRST-SYRGSLGKSLGNAPSYNAIHSY-RSPPKPGYGFKTTTLPYIRNGFSSDF 706

Human   614 ------DQRNANLAPCGAD--------------------------------------------PD 628
                  |:.::....||..                                            |:
  Fly   707 SYGGLGDKTHSTDLSCGKSEASVDSITEGDRRALMGGDLPASSTYSGALSYHYPQAGLIRRSLPN 771

Human   629 ASWGMREY---KIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWK 690
            .|..|..:   |||||..|::||   .:||.||||..||||||..||:.:...:..||.||..|:
  Fly   772 MSHSMLVHEPAKIYPYHLLLITN---YRLPSDVDRCNLERHLSDIEFEHILQCARSEFYRLPQWR 833

Human   691 RNDLKKKALLF 701
            ||:||::..||
  Fly   834 RNELKRRVKLF 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABLIM2	XP_005248071.1	LIM1_abLIM	29..80	CDD:188713	24/50 (48%)
		LIM2_abLIM	85..140	CDD:188714	30/56 (54%)
		LIM3_abLIM	158..209	CDD:188715	30/50 (60%)
		LIM4_abLIM	217..272	CDD:188716	31/81 (38%)
		AbLIM_anchor	282..665	CDD:292800	118/500 (24%)
		VHP	667..701	CDD:280388	13/33 (39%)
Unc-115a	NP_001163573.1	LIM1_abLIM	46..97	CDD:188713	24/50 (48%)
		LIM2_abLIM	102..157	CDD:188714	29/54 (54%)
		LIM3_abLIM	211..262	CDD:188715	30/50 (60%)
		LIM4_abLIM	270..326	CDD:188716	31/55 (56%)
		AbLIM_anchor	<783..808	CDD:292800	15/27 (56%)
		VHP	810..844	CDD:280388	13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160036
Domainoid	1	1.000	88	1.000	Domainoid score	I7921
eggNOG	1	0.900	-	-		E1_KOG1044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2046
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106653at33208
OrthoFinder	1	1.000	-	-		FOG0001360
OrthoInspector	1	1.000	-	-		mtm8549
orthoMCL	1	0.900	-	-		OOG6_103132
Panther	1	1.100	-	-	O	PTHR24213
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11864
SonicParanoid	1	1.000	-	-		X852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790