DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRSK1 and par-1

DIOPT Version :9

Sequence 1:	NP_115806.1	Gene:	BRSK1 / 84446	HGNCID:	18994	Length:	778	Species:	Homo sapiens
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	900	Identity:	258/900 - (28%)
Similarity:	382/900 - (42%)	Gaps:	241/900 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     2 SSGAKEGGGGSPAYHLPHPHPHPPQHA-QYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIV 65
            :|.||    |||...:....|...:.. :::|.|:|.||:|||....|||..|..||::|||||:
  Fly   224 TSSAK----GSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKII 284

Human    66 NREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTP 130
            ::.:|:...|.|:.||:.|:|:::||:::||..|.|.:|.|||::|:.||||:|||||..||:..
  Fly   285 DKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKE 349

Human   131 KEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPH 195
            ||||..|||||||:.:||...|.|||||.||||||.:.||:|||||.::.....|.|:|.||||.
  Fly   350 KEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPP 414

Human   196 YACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS 260
            ||.||:.:|:||||...|:||.||||:.|:.|:||||...||:|.|:|.||.:.:|.::..||::
  Fly   415 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCEN 479

Human   261 LLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPD--PCLEPAPGRRVAMRSLPSNGEL-DPDVLES 322
            |||..:.:.|.||.|||.|....|...|..|.:  |.:||             ..:| ||..:|:
  Fly   480 LLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEP-------------KADLADPKRIEA 531

Human   323 MASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPML 387
            :.::|  .:|..:...| |:....:....||||.||...|..:
  Fly   532 LVAMG--YNRSEIEASL-SQVRYDDVFATYLLLGRKSTDPESD---------------------- 571

Human   388 SRHGKRRPERKSMEVLSITDAG--GGGSPV--PTRRALEMA------QHSQRSRS----VSGAST 438
               |.|.....|:..:|..|||  .|.:.|  ||.|.:..:      :.|:|:.|    .:.|:|
  Fly   572 ---GSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAAT 633

Human   439 GLSSSPLSSPRSPVFSFSPEPGAGDEARGGGS-------------------------PTSKTQTL 478
            ..:::......:|..:::....|.|.|..|.:                         |.|.||.:
  Fly   634 VAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKM 698

Human   479 ---------------------PSRGPR--GGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSP 520
                                 |:.|.|  .|.:|..|    .|||.|.....|...:...|..:.
  Fly   699 LTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIP----RRSTTLYEKTSSTEKTNVIPAETN 759

Human   521 L--------------HTPRASP--------------------TGTPGTTPPPS-PGGGVGGAAWR 550
            |              |.||..|                    :||.|.:...| ||
  Fly   760 LFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPG--------- 815

Human   551 SRLNSIRNSFLG--SPRFHRRKMQVPT-AEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVL 612
                  |.||..  |.||.:|    || |:|      .:.|.:.:.:|.....|....:||...:
  Fly   816 ------RMSFFSKLSSRFSKR----PTIADE------AAKPRVLRFTWSMKTTSPLMPDQIMQKI 864

Human   613 KDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYK-------ASGGPSVFQKPVRFQVDISSS 670
            ::                       ||.|.:...|.:       ..|.|:. ...|::::::..
  Fly   865 RE-----------------------VLDQNNCDYEQRERFVLWCVHGDPNT-DSLVQWEIEVCK- 904

Human   671 EGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQT- 734
                 .||...:|      |.|..|||.|..||.:...|...|....:|.:     :|.|.|.|
  Fly   905 -----LPRLSLNG------VRFKRISGTSIGFKNIASRIAFDLKLXLNQTN-----NEGNAAATA 953

Human   735 -RPAGAPPRSLQPPPGRPDPELSS------------SPRRGPPKDKK-LLATNGT 775
             ||.............||..:.:|            :.::|..:.|| .|:|.|:
  Fly   954 SRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLCRSLTSQQGSQRRKKSRLSTGGS 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRSK1	NP_115806.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		7/27 (26%)
		STKc_BRSK1_2	32..285	CDD:270983	129/252 (51%)
		UBA_BRSK	314..367	CDD:270525	15/53 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..548		50/282 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..778		16/71 (23%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	128/251 (51%)
		S_TKc	253..504	CDD:214567	128/250 (51%)
		UBA_MARK_Par1	525..563	CDD:270522	11/40 (28%)
		MARK1-3_C	839..936	CDD:213381	24/132 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920