Protein Alignment DOT1L and DOT1

DIOPT Version :9

• Sequence 1: XP_005259716.1
• Gene: DOT1L / 84444
• HGNCID: 24948
• Length: 1738
• Species: Homo sapiens
• Sequence 2: NP_010728.1
• Gene: DOT1 / 852050
• SGDID: S000002848
• Length: 582
• Species: Saccharomyces cerevisiae
• Alignment Length: 342
• Identity: 94/342 - (27%)
• Similarity: 147/342 - (42%)
• Gaps: 64/342 - (18%)

Human    34 AHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKL 98
            |.::.|||      :|||..:.:|     .|||.|.:...|   ||:.|..|
Yeast   285 AEQLKETI------LPDLNASFDN-----SDTKGFVNAINL---YNKMIREI------------- 322

Human    99 NTRPSTGLLRHI--------------LQQVYNHSV-TDPEKLNNYEPFSPEVYGETSFDLVAQMI 148
               |...::.|:              |..||..|: ....||.:|:.||..||||...:.::.:.
Yeast   323 ---PRQRIIDHLETIDKIPRSFIHDFLHIVYTRSIHPQANKLKHYKAFSNYVYGELLPNFLSDVY 384

Human   149 DEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKK- 212
            .:.::...|.|:|||||||..|:|.|....|...:|.|..|..:........|.:|..|.||.:
Yeast   385 QQCQLKKGDTFMDLGSGVGNCVVQAALECGCALSFGCEIMDDASDLTILQYEELKKRCKLYGMRL 449

Human   213 -HAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLN 276
             :.|::|::....:....|.|....||.||||.|..:::.::::.....|.|.:|:|.|....|.
Yeast   450 NNVEFSLKKSFVDNNRVAELIPQCDVILVNNFLFDEDLNKKVEKILQTAKVGCKIISLKSLRSLT 514

Human   277 FRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAA 341
            ::||..|:.:|...::|......:.|||||.....||:.|:...:.|:.||           .||
Yeast   515 YQINFYNVENIFNRLKVQRYDLKEDSVSWTHSGGEYYISTVMEDVDESLFS-----------PAA 568

Human   342 RRRQQRESKSNAATPTK 358
            |.|:      |..||.|
Yeast   569 RGRR------NRGTPVK 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DOT1L	XP_005259716.1	DOT1	115..317	CDD:149273	61/204 (30%)
		Rootletin	493..661	CDD:291694
		Tropomyosin_1	508..660	CDD:289488
DOT1	NP_010728.1	DOT1	350..555	CDD:149273	61/204 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159046044
Domainoid	1	1.000	100	1.000	Domainoid score	I1754
eggNOG	1	0.900	-	-		E1_KOG3924
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5493
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto144681
orthoMCL	1	0.900	-	-		OOG6_103524
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.720