DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DOT1L and Dot1l

DIOPT Version :9

Sequence 1:	XP_005259716.1	Gene:	DOT1L / 84444	HGNCID:	24948	Length:	1738	Species:	Homo sapiens
Sequence 2:	XP_006513492.1	Gene:	Dot1l / 208266	MGIID:	2143886	Length:	1736	Species:	Mus musculus

Alignment Length:	1746	Identity:	1469/1746 - (84%)
Similarity:	1547/1746 - (88%)	Gaps:	18/1746 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDT 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDT 65

Human    66 KSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEP 130
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
Mouse    66 KSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEP 130

Human   131 FSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYA 195
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   131 FSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYA 195

Human   196 ETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANM 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 ETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANM 260

Human   261 KEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENY 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 KEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENY 325

Human   326 FSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPS 390
            |||||||||||||||||||||||:||||.||||.||.|.|. .:||.||||||||:|.|||||||
Mouse   326 FSSLKNPKLREEQEAARRRQQRENKSNATTPTKVPESKAAA-TEAPADSGAEEEKSGVATVKKPS 389

Human   391 PSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRS 455
            |||||||||||||||||||||||||||:.|:.|||.||:|:.||.||:...:..:| |||||||:
Mouse   390 PSKARKKKLNKKGRKMAGRKRGRPKKMSAASAERKSKKSQSTLDLLHSPPPAPPSA-SPQDAYRA 453

Human   456 PHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKE 520
            |||||||||||.|.||||||||||||||||||||||:|||||||||||||||||:||:||.||||
Mouse   454 PHSPFYQLPPSTQLHSPNPLLVAPTPPALQKLLESFRIQYLQFLAYTKTPQYKANLQQLLDQEKE 518

Human   521 KNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQL 585
            ||.||||.||||..|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   519 KNTQLLGTAQQLFGHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQL 583

Human   586 EQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKS 650
            |:||..||.|||:||:||||||:|||:|||||.|.||||||:||||||||||||||||||||||:
Mouse   584 EKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKT 648

Human   651 QRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNG 715
            ||||||||||||||||||||||||||||||||||.||.||.|||||.|.||||||||||||||||
Mouse   649 QRQQELLQLKSCVPPDDALSLHLRGKGALGRELEADAGRLRLELDCAKISLPHLSSMSPELSMNG 713

Human   716 QAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIV 780
            .||.||||...||||||||||||||||||||||||||||.||||||||||||.||||||||||||
Mouse   714 HAASYELCNAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIV 778

Human   781 LRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKS 845
            ||||||||||...:.|.||.|.|.||.||:.||||||.:..|||||||||...||....|..||.
Mouse   779 LRRHLSQDHTGASKAATSEPHPRPEHPKESSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSEKG 843

Human   846 SEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDP 910
            ||||::||||.|.||.|||||:|||||||||||||||||||||||||||||||||||||.||||.
Mouse   844 SEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDS 908

Human   911 SSTLEKQIGANAH-----GAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSS 970
            |:|||||.||:||     ||||||||:||.|| ||||||||||||.|||.|..|.|.|..||||.
Mouse   909 SATLEKQTGASAHGAGGAGAGSRSLAVAPTGF-YAGSVAISGALASSPAPLASGMESAVFDESSG 972

Human   971 SGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFS 1035
            ..|||||:||||:.||||.||:|.|||.||||||||::||||....||.||:.|||:||||..||
Mouse   973 PSSLFATMGSRSTPPQHPPLLSQSRNSGPASPAHQLTASPRLSVTTQGSLPDTSKGELPSDPAFS 1037

Human  1036 DPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLS 1100
            ||||||||||||:|:.|| |:|||||::|||||:..|||||.|||||||:|.|||||||||||||
Mouse  1038 DPESEAKRRIVFSISVGA-SSKQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLS 1101

Human  1101 AGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPV 1165
            .||||||||||:|||||||.|||||||||||||||||||||||||||:||||||.||||||||||
Mouse  1102 TGVSPKRRALPTVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPV 1166

Human  1166 LKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPA 1230
            |:|||||..||||||||||||||||||||||||||||||||||||||||||||||||||.|||.|
Mouse  1167 LRKERPLGLTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLVGRKSA 1231

Human  1231 PAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKG 1295
            |:.||:||||||||||||||:||||:.||||||.||||.:.||:|||:||||:|:|||..||||.
Mouse  1232 PSSEPINSSKWKSTFSPISDLGLAKAVDSPLQAGSALSHSPLFSFRPSLEEPAAEAKLPTHPRKS 1296

Human  1296 FPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKE 1360
            |.|||..|:|.||||||.||..|.|||||||.||||:|||||.||||:..|||:.|||||||||:
Mouse  1297 FAGSLGAAEGPSPGTNPPNGLAFSGGLAADLGLHSFNDGASLSHKGPDVTGLSASLSFPSQRGKD 1361

Human  1361 G-SDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSG-KAAKARDREVDLKNG 1423
            . ::||||||:||.:||.||||||:..||:|| .||||||:||..|..| :|:|.||||:|.|.|
Mouse  1362 STTEANPFLSRRQPEGLGGLKGEGNANKESGE-SLPLCGPSDKASLPHGSRASKGRDRELDFKGG 1425

Human  1424 HNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSV 1488
            |||||||||||||.||.||||...|||||.|..:||..|.||..|.|||||.|||||||||||||
Mouse  1426 HNLFISAAAVPPGGLLGGPGLVTVASSAGSATPTAQAPRPFLSTFAPGPQFTLGPMSLQANLGSV 1490

Human  1489 AGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSF-SGVAGGTVGGVFNHAVPSASAHPFGA 1552
            |||||||||||:||||||||||||.||||||||.|||| ||||||||||||.|||||||||||||
Mouse  1491 AGSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGVFTHAVPSASAHPFGA 1555

Human  1553 RVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPV 1617
            .||.||.|.|||||.||||||||.|||||||.||||||     |||||||.||.||||.||||||
Mouse  1556 GVGSGAVCSSATLGLSPLQAAASTSASSFQAAASVETR-----PPPPPPLLPPQHLGRPPAGPPV 1615

Human  1618 LHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHK 1682
            ||||||||.||||||.||||||||.|||||||||.|.|||||:|||||.|||||||:||.|||||
Mouse  1616 LHAPPPPNVALPPPPALLASNPEPVLLQSLASLPANNAFLPPSSAASLQPANASLSVKLASLPHK 1680

Human  1683 GARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR 1738
            .:|||||||||||||||||||||..||||.:|||||||||||||||||||||||||
Mouse  1681 VSRPSFTVHHQPLPRLALAQAAPAAPQASTSGPSAVWVSLGMPPPYAAHLSGVKPR 1736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DOT1L	XP_005259716.1	DOT1	115..317	CDD:149273	200/201 (100%)
		Rootletin	493..661	CDD:291694	148/167 (89%)
		Tropomyosin_1	508..660	CDD:289488	132/151 (87%)
Dot1l	XP_006513492.1	DOT1	115..317	CDD:149273	200/201 (100%)
		Mplasa_alph_rch	<510..>659	CDD:275316	130/148 (88%)
		PHA03307	781..>1125	CDD:223039	254/345 (74%)
		Herpes_BLLF1	<942..1314	CDD:282904	297/372 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83952701
Domainoid	1	1.000	1894	1.000	Domainoid score	I369
eggNOG	1	0.900	-	-		E1_KOG3924
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32779
Inparanoid	1	1.050	2545	1.000	Inparanoid score	I888
Isobase	1	0.950	-	0	Normalized mean entropy	S5493
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39131
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto113385
orthoMCL	1	0.900	-	-		OOG6_103524
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2094
SonicParanoid	1	1.000	-	-		X5335
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.240