DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DOT1L and dot-1.4

DIOPT Version :9

Sequence 1:	XP_005259716.1	Gene:	DOT1L / 84444	HGNCID:	24948	Length:	1738	Species:	Homo sapiens
Sequence 2:	NP_509997.1	Gene:	dot-1.4 / 186332	WormBaseID:	WBGene00010120	Length:	383	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	104/347 - (29%)
Similarity:	175/347 - (50%)	Gaps:	41/347 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    27 YDKH-HDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCD--KYNRAIDSIHQL 88
            :|.| |.....::..::.:.|.:.: :|::|   ||..:.|:..:...|.:  |:|.|:....:
Worm    45 FDSHKHHVPVILLNMLKELFEPVLN-QLSIE---LIAANGKTTNTDNVLAELAKFNEAVALFRR- 104

Human    89 WKGTTQPMKLNTRP--------STGLLRHILQQVYNHSVTDPEKLN-NYEPFSPEVYGETSFDLV 144
                ..|.|....|        :..:.:.|.:...:.||..|:||| :|:.||.|.||||..:.:
Worm   105 ----DNPKKQLLLPKHWDQSTCTQQVAQKITEIAKDLSVPYPKKLNQHYKGFSSETYGETMLEQI 165

Human   145 AQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWY 209
            ..::||:|:...|:|||||||:||:|..|||.:..|...|:|.:.:||:||.:....|:..|.::
Worm   166 GSIVDELKLNSSDVFVDLGSGIGQLVCFVAAYSKVKKAVGIELSSVPAEYAVSQGMYFKNLMTFF 230

Human   210 GKKHAEYTLERGDFLSEEWRERIA-NTSVIFVNNFAFGPEVDHQLK-ERFANMKEGGRIVSSKPF 272
            .|:|.|..|.:||||..::.:.|. ..:|||:||:||..::..::. |...|..:|.||||:||.
Worm   231 DKQHGEIELIQGDFLHPQFHDLICKEATVIFINNYAFEDDLTRRIVFELLQNCADGTRIVSAKPL 295

Human   273 A-PLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLRE 336
            : |.:.......:||.|::.....|...:.:||||...|.:.|.|:|...|   |.|.:
Worm   296 SLPRSVASRRHAMSDFGSMSNSRTLRATESNVSWTSNIVEFTLTTVDHLKL---FKSFE------ 351

Human   337 EQEAARRRQQRESKSNAATPTK 358
                    .|:|||.:|.:..|
Worm   352 --------MQKESKKSANSKVK 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DOT1L	XP_005259716.1	DOT1	115..317	CDD:149273	76/205 (37%)
		Rootletin	493..661	CDD:291694
		Tropomyosin_1	508..660	CDD:289488
dot-1.4	NP_509997.1	AdoMet_MTases	140..341	CDD:302624	74/200 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I3220
eggNOG	1	0.900	-	-		E1_KOG3924
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5493
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55132at33208
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		otm15628
orthoMCL	1	0.900	-	-		OOG6_103524
Panther	1	1.100	-	-	O	PTHR21451
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.800