Protein Alignment DOT1L and dot1l

DIOPT Version :9

• Sequence 1: XP_005259716.1
• Gene: DOT1L / 84444
• HGNCID: 24948
• Length: 1738
• Species: Homo sapiens
• Sequence 2: XP_012809749.1
• Gene: dot1l / 100497594
• XenbaseID: XB-GENE-6033925
• Length: 1396
• Species: Xenopus tropicalis
• Alignment Length: 1558
• Identity: 942/1558 - (60%)
• Similarity: 1094/1558 - (70%)
• Gaps: 183/1558 - (11%)

Human     1 MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDT 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog     1 MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDT 65

Human    66 KSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEP 130
            |.||||||||:|||||||||||||||||.||||.|||||||||||||||||||||||||||||||
 Frog    66 KCFESMQRLCEKYNRAIDSIHQLWKGTTHPMKLKTRPSTGLLRHILQQVYNHSVTDPEKLNNYEP 130

Human   131 FSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYA 195
            ||||||||||||||||||||||||:||||||||||||||||||||||.|||||||||||||||||
 Frog   131 FSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATGCKHHYGVEKADIPAKYA 195

Human   196 ETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANM 260
            ||||.|||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 ETMDTEFRKWMKWYGKKHSEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANM 260

Human   261 KEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENY 325
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
 Frog   261 KEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTLLENY 325

Human   326 FSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPS 390
            |||||||||||||||||||||||.|||..||||..|.|         ||.|||||  :|.|||.|
 Frog   326 FSSLKNPKLREEQEAARRRQQREGKSNTTTPTKVHETK---------DSAAEEEK--SAPVKKAS 379

Human   391 PSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTV---SQTAASSPQDA 452
            |:||| :||:||||||||||||||||:.|...:||..|:||||:.||.|.|   .....|.|||:
 Frog   380 PAKAR-RKLSKKGRKMAGRKRGRPKKLLTTTADRKSSKSQTALETLHPQNVLVPQSPTKSPPQDS 443

Human   453 YRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQ 517
            |::||||:|||||.|||...|.||.:||||||||||:||:|||||.::|.|||.|||.||:||.|
 Frog   444 YKTPHSPYYQLPPKVQRQPSNQLLSSPTPPALQKLLDSFRIQYLQLMSYMKTPHYKAGLQQLLEQ 508

Human   518 EKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQS 582
            |||||:.|||||||||:|||||||||::||||||||||||||||:|||||||||.||||||:|||
 Frog   509 EKEKNSHLLGAAQQLLTHCQAQKEEIKKLFQQKLDELGVKALTYSDLIQAQKEIFAHNQQLKEQS 573

Human   583 EQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVEL 647
            .|||::|.|||..||||||||||||:|||.|||||.|:|||.|||:||||||:||||||||||||
 Frog   574 RQLEEENGALRNHSLQLLKARCEELKLDWNTLSLENLMKEKLALKNQISEKQKHCLELQISIVEL 638

Human   648 EKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLP---HLSSMSP 709
            ||.|||||||||||...|::....|.|.||:||       :..|.|....:...|   |.:.:||
 Frog   639 EKFQRQQELLQLKSSTLPEEPPPSHNRTKGSLG-------NHFHAEQSSVRMMPPPSSHTNGLSP 696

Human   710 ELSMNGQAAGYEL---CGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDY 771
            |.|:||.|:.|||   |...|||.||::||.:..   ..::||.|.:|..:.:.||:||...|||
 Frog   697 ERSLNGHASHYELYHSCRGGSRPCSKESTPSHSE---HADIVPSTQTHAAKHKGEKISGPTQPDY 758

Human   772 TRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPG 836
            ||.|||||.:||||:|:....||  ::|::.|...||::..|..||.:|..::.|||:..|.||.
 Frog   759 TRYSPAKIAMRRHLNQEPLPNGR--STEINHRCNVTKDHSFPSISPGIPNGVQFSPQESNPSSPE 821

Human   837 ALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTP 901
            .....||:..||..|||...|:.|.||||||||||||||||||||||||||||||||.|: |::|
 Frog   822 LTHTPGERGPEKMFRERNSPSNPETITSLPISIPLSTVQPNKLPVSIPLASVVLPSRVEK-RNSP 885

Human   902 SPVLQPRDPSSTLEKQIGANAHGAGSRSLA-------LAPAGFSY-AGSVAISGALAGSPASLTP 958
            ||....||.|      :..|.:||.|.||:       ||.:||.| ..|.:::|.:..|..|.|.
 Frog   886 SPGCHSRDGS------LSENQYGATSNSLSYAAVSKPLATSGFFYPTWSSSLNGPVLNSHGSETD 944

Human   959 GAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPA-HQLSSSPRLGGAAQGPLPE 1022
            |     :|:||:||:|..:.|||||||.|..|::|      .||| |..|:||       ...|:
 Frog   945 G-----MDDSSNSGTLSNSGGSRSSTPSHSHLISQ------RSPAQHSTSASP-------CTFPD 991

Human  1023 ASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRR- 1086
            .|||....|...||.|.||||||:||||:|:.:.: |||:|||||||:.|.:|  ..|||::||
 Frog   992 PSKGSGEGDIDTSDAEMEAKRRIIFTITSGSSNGR-SPSNKHSPLTATIRMEC--GTGQDAKRRS 1053

Human  1087 GRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLK 1151
            |||||:|||  |.::.||||||:||:..||.:..||||||::|||||||||||||||||||.|:|
 Frog  1054 GRRKRSSAG--SHNSAVSPKRRSLPTSVGLNSYTSGSPLNISSMVSNINQPLEITAISSPEASMK 1116

Human  1152 SSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPK 1216
            |||..||||:.|||||||:|||.:||.||||||:::|..||::..|.|.|||.:::..|||..|:
 Frog  1117 SSPASYQDHELPPVLKKEKPLSLSNGVHYSPLTTEDEAESEEDTQSTRTERKSSSLCFESKDSPQ 1181

Human  1217 TLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEE 1281
            ..|...||.......:.|.|   |||:|||||||....:::|||   ||...||:
 Frog  1182 RSEGERGLPYSSKKSSCESV---KWKATFSPISDATPGRASDSP---SSPHRQNT---------- 1230

Human  1282 PSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAG 1346
                     |...| .|...|:.|||||:  |||             ||
 Frog  1231 ---------HYSSG-EGGRRGSGGLSPGS--ANG-------------HS---------------- 1254

Human  1347 LSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAA 1411
                 ..|...|.:| :.|.||||:       :..|||:.::.        |||.|....|.|..
 Frog  1255 -----DHPRVEGGKG-ECNLFLSKK-------MSSEGSKREDR--------GPTAKLDRSSSKVP 1298

Human  1412 KARDREVDLKNGHNLFISAAAVPPGSLLS--GPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQF 1474
            ::|:|:     |:.:|::...   |:|::  |||..|           ...|..||.....|.|.
 Frog  1299 RSRERD-----GNTVFMTQGT---GALMNGKGPGSNP-----------LHPHHHFLNSLAAGSQL 1344

Human  1475 ALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGV 1537
            |     ||..|.|||.:|||||:|||:|     |||:..|.||:|||:|..|: ..||||||:
 Frog  1345 A-----LQGGLNSVASNSVLQSIFSSIP-----VHVTGPAGRLSNSHSMSGFT-APGGTVGGI 1396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DOT1L	XP_005259716.1	DOT1	115..317	CDD:149273	197/201 (98%)
		Rootletin	493..661	CDD:291694	137/167 (82%)
		Tropomyosin_1	508..660	CDD:289488	126/151 (83%)
dot1l	XP_012809749.1	DOT1	115..317	CDD:149273	197/201 (98%)
		Smc	<498..>653	CDD:224117	129/154 (84%)
		Herpes_BLLF1	<715..1128	CDD:282904	224/447 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1005	1.000	Domainoid score	I647
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32779
Inparanoid	1	1.050	1641	1.000	Inparanoid score	I1128
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15121at32523
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto148709
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5335
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.160