Protein Alignment DYRK3 and CG7028

DIOPT Version :9

• Sequence 1: NP_003573.2
• Gene: DYRK3 / 8444
• HGNCID: 3094
• Length: 588
• Species: Homo sapiens
• Sequence 2: NP_001286884.1
• Gene: CG7028 / 38032
• FlyBaseID: FBgn0027587
• Length: 912
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 137/507 - (27%)
• Similarity: 227/507 - (44%)
• Gaps: 67/507 - (13%)

Human    62 LNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSS----- 121
            :|:..:....|..:..::....|.|:|.::.|..:.:....:.:|..   |.:.|||.|.
  Fly   431 VNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVSYE---SRSTSQGSSQRERPL 492

Human   122 -------DCLNTVKS----------NSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIY 169
                   .|.|.:.|          ||:|:.      |.....|:.:..:.|.:.:: .|:....
  Fly   493 RTPSPTMPCPNPLISEIPKDREDMDNSTSQK------TCSAKEKRNEWDMFADQDVD-SNFDVSR 550

Human   170 FVGPN--AKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR 232
            .:.||  .:.:|..........:|||:|.|.....:.|..||.|....|:|.|..|.|..|....
  Fly   551 KISPNTIVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARG 615

Human   233 Q-YVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLY 296
            | .||:|::||.:..|:....|:.||:.|...|.....:.:.:...|..:.|:||.||.|:::|.
  Fly   616 QANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLR 680

Human   297 ELIKK-NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS-S 359
            |::|| .|..|..::.||.:.|.:..:|..|.|..|:|.|:||:|||: :......|:.|||| |
  Fly   681 EVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILV-NENNLILKLCDFGSAS 744

Human   360 CFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424
            .....::..|:.|||||:||||||..|...||.||.||.:.||.||:.||.|:.....|...|::
  Fly   745 AISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDV 809

Human   425 LGMPPPKLLEQSK-RAKYFINSKGIPRYCSV-------TTQADGRVVLVGGRSRRGKKRG----- 476
            .|..|.:::.:.: |.::|..|      |:.       .|:.:..||:...:..|..::.
  Fly   810 KGKIPNRIIRKGQFREQHFDQS------CNFLYHEIDKLTEREKIVVMPVVKPSRSLQQELIADQ 868

Human   477 --PPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 526
              |.......|.||        :.|:.....||:.|::..|||.||:|.:.:
  Fly   869 NLPDDQHRKVTQLK--------DLLENMFALDPAKRISLNQALVHPFIQEKM 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYRK3	NP_003573.2	Disordered. /evidence=ECO:0000305|PubMed:23415227	1..188		25/149 (17%)
		PKc_DYRK2_3	143..522	CDD:271126	117/398 (29%)
		S_TKc	209..522	CDD:214567	104/330 (32%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:29973724	468..481		2/19 (11%)
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	105/331 (32%)
		S_TKc	599..908	CDD:214567	102/323 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810