Protein Alignment DYRK3 and mnb

DIOPT Version :9

• Sequence 1: NP_003573.2
• Gene: DYRK3 / 8444
• HGNCID: 3094
• Length: 588
• Species: Homo sapiens
• Sequence 2: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Alignment Length: 561
• Identity: 191/561 - (34%)
• Similarity: 275/561 - (49%)
• Gaps: 114/561 - (20%)

Human    71 GDHTQHFLDGGEMKVEQLFQEFGNRKSN-----TIQSDGISDSEKCSPTVSQGKSS--------- 121
            ||..:..:||..:.|:.........|:.     |:.:.|.|..   |...:||..|
  Fly   125 GDRDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGG---SVDAAQGSGSGGGRQRHAP 186

Human   122 ----------------DCLNTVKSNSSS--------------KAPKVVPL--TPEQALKQYKHHL 154
                            |.::...|.|||              :.|...||  .....:|.|||
  Fly   187 LYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKH-- 249

Human   155 TAYEKLEIINYPEIYFVGPNAKKR------HGVIGGPN-------NGGYDDADGAYIHVPRDHLA 206
                    ||  |:|:    |||:      .|.....|       |.||||.:..||....:...
  Fly   250 --------IN--EVYY----AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFL 300

Human   207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271
            .|||:..:|||||||||.:.|||:.:.:||:|:::|:|.|..||..|:::||.:.:.|......:
  Fly   301 DRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYI 365

Human   272 IHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH--KNKIIHC 334
            :.:...|.:|||:|:.|||||.:||:|::...|:|.|:.|.|||||.:..:|..|.  :..||||
  Fly   366 VKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHC 430

Human   335 DLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCIL 399
            |||||||||.:..||:.|::||||||...|::|.||||||||:||::||.:|...||:||.||||
  Fly   431 DLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCIL 495

Human   400 AELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVL 464
            .|:.||:|||.|.:|.||:..::|:|||||..||:|:.:.:.|.:.          ..|||..||
  Fly   496 VEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK----------IVADGSYVL 550

Human   465 VGGRSRRGKKRGPPGSKDWGTAL----------------KGCDDYL-FIEFLKRCLHWDPSARLT 512
              .:::.|:|..||||:.....|                ....||| |.:.:.|.|.:||..|:|
  Fly   551 --KKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVT 613

Human   513 PAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGS 553
            |..||:|.:..::......|    ||......|.| .|.||
  Fly   614 PYYALQHNFFKRTADEATNT----SGAGATANAGA-GGSGS 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYRK3	NP_003573.2	Disordered. /evidence=ECO:0000305|PubMed:23415227	1..188		34/175 (19%)
		PKc_DYRK2_3	143..522	CDD:271126	162/410 (40%)
		S_TKc	209..522	CDD:214567	141/331 (43%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:29973724	468..481		5/12 (42%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	144/350 (41%)
		S_TKc	303..623	CDD:214567	141/331 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.780