DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSMAF and mv

DIOPT Version :9

Sequence 1:	NP_001138244.1	Gene:	NSMAF / 8439	HGNCID:	8017	Length:	948	Species:	Homo sapiens
Sequence 2:	NP_647681.2	Gene:	mv / 38259	FlyBaseID:	FBgn0265988	Length:	3535	Species:	Drosophila melanogaster

Alignment Length:	853	Identity:	225/853 - (26%)
Similarity:	333/853 - (39%)	Gaps:	225/853 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   186 RASCLDKLGDQTAMITAILQSRLARTSFDKNR--FQN-------------------------ISE 223
            ||.|..:|.|...  .:.:.:||.|...|.:|  |.|                         ..:
  Fly  2619 RAECSWELDDTEG--PSRVHTRLRRCHLDIDRRFFMNEYRPGQGHREDLEPYVRPLDYLIASYDQ 2681

Human   224 KLHMECKAEMVTPLVTN--------PGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHG 280
            :|::...::::......        .|.:.|||..|||..........|...:.::..|:.:|:.
  Fly  2682 QLNISLNSQILYNFAAKFLPVDGEIEGEIIITDLKLYFLATYRCRYFNVNCDIANITEIWLKRYQ 2746

Human   281 LMPLGLEVFC-TEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVA---EHTAESYMLQWQRGHL 341
            ......|:.. |...|       |:..|:.||.......:.:..||   :....:...||:.|.|
  Fly  2747 HQETAFEILLDTNKSL-------FFSLQNADDWKIMREVFCDKIVATPDQSKVIAITQQWREGLL 2804

Human   342 SNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLL 406
            :|::||:.||.::.|:.|||.|||||||::.:|:|..|||.....||.|.:|:....:|..:..:
  Fly  2805 TNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGHNFRRLGRPIAVQVEENEKHYI 2869

Human   407 TRYQEMPEPK----------FMYGSHYSSPGYVLFYLVRIAP--EYMLCLQNGRFDNADRMFNSI 459
            :.|..:....          :.|.||||:.|.||.:|||:.|  .|.|..|:..||..||.|:::
  Fly  2870 SNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFTSYFLRYQDNDFDLPDRTFHAL 2934

Human   460 AETW-KNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPED---F 520
            ..|| ....|..||.|||||||:.....| .|..:...|.||.|:.|:||.||||  |..|   |
  Fly  2935 NTTWLLASRDSPTDVKELIPEFFCLPEMF-ENFERFKFGCRQNGERVEDVSLPPW--SQRDSRLF 2996

Human   521 LQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAML 585
            :...:.||||..|...:|.||||||||||.|..||.|.|||||.||...:| :.|.||.|:.|:.
  Fly  2997 VLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPATYAVFLD-SEISDPIEREAVK 3060

Human   586 TQILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDL-------TEESKTL 643
            |.:..:||.|:|||.:|||         .|:...|  |:...|...:...|       :.:.|..
  Fly  3061 TMVKTYGQMPRQLFKSPHP---------ASKPLDY--SLVGKPIVSTVRGLRWGVYVGSPQLKAP 3114

Human   644 AWNNITKLQLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSS 708
            :|.||.|:...||.                                         :||.|  .:.
  Fly  3115 SWANIHKIPGTEHL-----------------------------------------VSFCN--TNV 3136

Human   709 CLLLPGDATVITSSWDNNVYFYSIAFGRRQDTL----MGHDDAVSKICWHDNRLYSASWDSTVKV 769
            ...|||.|:|:.              |...||.    .|:||.:.:|
  Fly  3137 VYALPGRASVMQ--------------GAEPDTYNVISWGYDDRIVRI------------------ 3169

Human   770 WSGVPAEMPGTKRHHFDLLAELEHDVSVDTIS---LNAASTLLVSGTKEGTVNIWDLTTATLMHQ 831
               .|...|..|..:      |.|:.:.|.|:   .:..|..|..|.|.|.::::
  Fly  3170 ---QPLNKPQAKPKN------LLHNGTFDDITACGCDVNSNQLWFGHKSGRISVY---------- 3215

Human   832 IPCHSGIVCDTAFSPDSRHVLSTGTD-----------------GCLNVIDVQTGML--ISSMTSD 877
             .|..|:......|..||...:.|..                 |....:| :.|.|  .||.:|
  Fly  3216 -KCTGGLDSQQRASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVD-EAGNLHPTSSASS- 3277

Human   878 EPQRCFVWDGNSVLSG----SQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGED 938
                   .:.:|:.||    .:.|..|.|  ||..:..|   ||..:|||.::.:....:|.|.|
  Fly  3278 -------VNSSSISSGGDAFQRDGADLNW--LGPTLLVR---HTDEITCITLSVEFKIAVTAGRD 3330

Human   939 RQIIFWKL 946
            ...:.|.|
  Fly  3331 GIAVIWDL 3338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSMAF	NP_001138244.1	PH-like	223..316	CDD:302622	18/101 (18%)
		Beach	335..606	CDD:280327	122/286 (43%)
		WD40	<645..947	CDD:225201	65/332 (20%)
		WD40	653..945	CDD:238121	59/321 (18%)
		WD40 repeat	664..701	CDD:293791	0/36 (0%)
		WD40 repeat	707..743	CDD:293791	8/39 (21%)
		WD40 repeat	748..782	CDD:293791	3/33 (9%)
		WD40 repeat	798..833	CDD:293791	7/37 (19%)
		WD40 repeat	839..875	CDD:293791	10/54 (19%)
		WD40 repeat	882..914	CDD:293791	9/35 (26%)
		WD40 repeat	920..944	CDD:293791	6/23 (26%)
mv	NP_647681.2	PH-like	2704..2785	CDD:418428	17/87 (20%)
		Beach	2796..3080	CDD:214982	122/296 (41%)
		WD40	<3308..3507	CDD:421866	10/31 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820