DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAD54L and okr

DIOPT Version :9

Sequence 1:	NP_001136020.1	Gene:	RAD54L / 8438	HGNCID:	9826	Length:	747	Species:	Homo sapiens
Sequence 2:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	414/756 - (54%)
Similarity:	548/756 - (72%)	Gaps:	24/756 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRRSLAPSQLAKRKPEGRSCDDEDWQPGLVTPRKRKSSSETQIQECFLSPFRKPLSQL-----TN 60
            |||||||||....:||.|    ..:.|.|:...||....|.:.::   ...|:.|..|     |:
  Fly     1 MRRSLAPSQRGPLRPESR----HSFTPPLLKKNKRSCQQELEREQ---ELDRRRLGALRDASNTS 58

Human    61 QPPC----LDSSQHEAFIRSILSKPFKVPIPNYQGPL-GSRALGLKRAGVRRALHDPLEKDALVL 120
            :.|.    ..:|::|..|..:|::.||||:.||.... |.|.||::|...||.||||:..:||||
  Fly    59 ELPLPIRFTANSEYELAIAKVLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPMACNALVL 123

Human   121 YEPPPLSAHDQLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGS-HGCIMADE 184
            :.||..:.|:::.:|..|:.|||||||:||.:|||||||||:|::|||..:|  |: :|||||||
  Fly   124 FHPPAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEGKR--GNFNGCIMADE 186

Human   185 MGLGKTLQCITLMWTLLRQSPECKPEIDKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKD 249
            |||||||||:||:||||||.|||||.|:||:|||||||||||..|..|||.||:..|.::||:|:
  Fly   187 MGLGKTLQCVTLVWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKE 251

Human   250 EIDQKLEGFMNQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDS 314
            ...:.||.| :...||:.:|:|:|||||||::..:|.|..||:||||||||||||:|.|||||..
  Fly   252 NTIRALEQF-SMTSARLGTPVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMG 315

Human   315 LNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEE 379
            |.|.||||:|||||||||.||:|||:|||..:||||..||::||..||:|::..::|.:||...|
  Fly   316 LKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIE 380

Human   380 RLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPAEELLE--GKM 442
            :.:||..:|::|:||||:.||:||||||.|.|:|.:||.:|.|||..||:..:....|.:  .|.
  Fly   381 KTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKA 445

Human   443 SVSSLSSITSLKKLCNHPALIYDKCVEEEDGFVGALDLFPPGYSSKALEPQLSGKMLVLDYILAV 507
            |:::|:.||:|||:|:||.|||:|....|.||..:.::.|..|..|.|.|:||||.::||::||.
  Fly   446 SLTALADITTLKKICSHPDLIYEKLTAREKGFENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAA 510

Human   508 TRSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLS 572
            .|:..:|||||:|||||||||||:|.|.|:|.:||||||||||||:|||:|||.|.|..|:||||
  Fly   511 IRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLS 575

Human   573 SKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSH 637
            ||||||||||||||||.|||||||||||||||||||||||||.||||||:::|:|||||.|||:|
  Fly   576 SKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTH 640

Human   638 KKALSSCVVDEEQDVERHFSLGELKELFILDEASLSDTHDRLHCRRCVNSRQIRPPPDGSDCTSD 702
            ||:|||.::|..:..|:||:..:||:||..|...||||||:|.|:|||.:.|::|||:.:||||.
  Fly   641 KKSLSSTIIDNNESAEKHFTRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQMKPPPEDTDCTSH 705

Human   703 LAGWNHCTDKWGLRDEVLQAAWDAASTAITFVFHQRSHEEQ 743
            |:.|.||::..||.|.:|..|| .....::||||.||..::
  Fly   706 LSQWYHCSNNRGLPDNILAQAW-MDCKCVSFVFHHRSQAQE 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAD54L	NP_001136020.1	SNF2_N	156..463	CDD:278600	178/309 (58%)
		DEXDc	177..327	CDD:238005	97/149 (65%)
		DEGH box	296..299		2/2 (100%)
		Helicase_C	495..611	CDD:278689	89/115 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		16/39 (41%)
		Required for chromatin remodeling, strand pairing activities and coupling of ATPase activity. /evidence=ECO:0000250	2..9		6/6 (100%)
		Rad54_N	<74..>123	CDD:285821	23/49 (47%)
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	178/309 (58%)
		DEXDc	179..328	CDD:238005	97/149 (65%)
		HELICc	493..622	CDD:238034	99/128 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146349
Domainoid	1	1.000	338	1.000	Domainoid score	I1110
eggNOG	1	0.900	-	-		E2759_KOG0390
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48227
Inparanoid	1	1.050	817	1.000	Inparanoid score	I476
Isobase	1	0.950	-	0	Normalized mean entropy	S723
OMA	1	1.010	-	-		QHG58624
OrthoDB	1	1.010	-	-		D93727at2759
OrthoFinder	1	1.000	-	-		FOG0001533
OrthoInspector	1	1.000	-	-		oto89454
orthoMCL	1	0.900	-	-		OOG6_102456
Panther	1	1.100	-	-	LDO	PTHR45629
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1064
SonicParanoid	1	1.000	-	-		X3107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750