DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAD54L and Rad54l

DIOPT Version :9

Sequence 1:	NP_001136020.1	Gene:	RAD54L / 8438	HGNCID:	9826	Length:	747	Species:	Homo sapiens
Sequence 2:	NP_001128432.1	Gene:	Rad54l / 298429	RGDID:	1310600	Length:	748	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	700/746 - (93%)
Similarity:	720/746 - (96%)	Gaps:	0/746 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRRSLAPSQLAKRKPEGRSCDDEDWQPGLVTPRKRKSSSETQIQECFLSPFRKPLSQLTNQPPCL 65
            |||||||||||:||||..|.|||||||..|||:||||::|||.|:||||||||||:||.|:||||
  Rat     1 MRRSLAPSQLARRKPEDISSDDEDWQPETVTPKKRKSTAETQAQQCFLSPFRKPLTQLLNRPPCL 65

Human    66 DSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKRAGVRRALHDPLEKDALVLYEPPPLSAHD 130
            |||||||||||||||||||||||||||||||||||||||||||||||||:.|||||||||||.||
  Rat    66 DSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKRAGVRRALHDPLEEGALVLYEPPPLSVHD 130

Human   131 QLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCIT 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 QLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCIT 195

Human   196 LMWTLLRQSPECKPEIDKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMN 260
            ||||||||||||||||:||||||||||||||||||.|||||||||||||||||||||:|||||||
  Rat   196 LMWTLLRQSPECKPEIEKAVVVSPSSLVKNWYNEVEKWLGGRIQPLAIDGGSKDEIDRKLEGFMN 260

Human   261 QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISG 325
            ||||||.|||||||||||||||.||:||:||||||||||||||||||||||||||||||||||||
  Rat   261 QRGARVPSPILIISYETFRLHVEVLKKGNVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISG 325

Human   326 TPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNR 390
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||.|||||
  Rat   326 TPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKSRDAAASEADRQLGEERLRELISIVNR 390

Human   391 CLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPAEELLEGKMSVSSLSSITSLKK 455
            |||||||||||||||||||||||||||||||||||||||||||.|||.|||||||||||||||||
  Rat   391 CLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPEEELHEGKMSVSSLSSITSLKK 455

Human   456 LCNHPALIYDKCVEEEDGFVGALDLFPPGYSSKALEPQLSGKMLVLDYILAVTRSRSSDKVVLVS 520
            |||||||||||||.|||||.|.|.:|||||:|||:||||||||||||||||:|||||||||||||
  Rat   456 LCNHPALIYDKCVAEEDGFEGTLGIFPPGYNSKAVEPQLSGKMLVLDYILAMTRSRSSDKVVLVS 520

Human   521 NYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGLNLIGA 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 NYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGLNLIGA 585

Human   586 NRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQ 650
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
  Rat   586 NRLVMFDPDWNPANDEQAMARVWRDGQKKICYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQ 650

Human   651 DVERHFSLGELKELFILDEASLSDTHDRLHCRRCVNSRQIRPPPDGSDCTSDLAGWNHCTDKWGL 715
            |||||||||||||||.||||||||||||||||||||:||:.|||||||||||||.|||.|||.||
  Rat   651 DVERHFSLGELKELFTLDEASLSDTHDRLHCRRCVNNRQVWPPPDGSDCTSDLAQWNHNTDKRGL 715

Human   716 RDEVLQAAWDAASTAITFVFHQRSHEEQRGL 746
            :||||||||||:|||||||||||||||||||
  Rat   716 QDEVLQAAWDASSTAITFVFHQRSHEEQRGL 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAD54L	NP_001136020.1	SNF2_N	156..463	CDD:278600	295/306 (96%)
		DEXDc	177..327	CDD:238005	142/149 (95%)
		DEGH box	296..299		2/2 (100%)
		Helicase_C	495..611	CDD:278689	114/115 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		30/39 (77%)
		Required for chromatin remodeling, strand pairing activities and coupling of ATPase activity. /evidence=ECO:0000250	2..9		6/6 (100%)
		Rad54_N	<74..>123	CDD:285821	46/48 (96%)
Rad54l	NP_001128432.1	Rad54_N	<74..>123	CDD:285821	46/48 (96%)
		SNF2_N	156..463	CDD:278600	295/306 (96%)
		DEXDc	177..327	CDD:238005	142/149 (95%)
		HELICc	490..619	CDD:238034	125/128 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83681065
Domainoid	1	1.000	549	1.000	Domainoid score	I5874
eggNOG	1	0.900	-	-		E2759_KOG0390
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48227
Inparanoid	1	1.050	1411	1.000	Inparanoid score	I3084
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG58624
OrthoDB	1	1.010	-	-		D16019at314146
OrthoFinder	1	1.000	-	-		FOG0001533
OrthoInspector	1	1.000	-	-		oto134409
orthoMCL	1	0.900	-	-		OOG6_102456
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.170