Protein Alignment ARFGAP2 and ArfGAP3

DIOPT Version :10

• Sequence 1: XP_005253223.1
• Gene: ARFGAP2 / 84364
• HGNCID: 13504
• Length: 560
• Species: Homo sapiens
• Sequence 2: NP_001097664.2
• Gene: ArfGAP3 / 40487
• FlyBaseID: FBgn0037182
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 223/612 - (36%)
• Similarity: 318/612 - (51%)
• Gaps: 119/612 - (19%)

Human     2 AAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRST 66
            ||.|:|.||:::|.||||.|.||:||||.||.|:|:|:|||:|:|||||.|||:|||||:|:|||
  Fly     5 AAGPSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRST 69

Human    67 ELDSNWNWFQLRCMQVGGNANATAFFRQHGCTANDANTKYNSRAAQMYREKIRQLGSAALARHGT 131
            .||:||.|.|||.||:||||||..|||.|.|:..||..||||||||:||:|:......|:..|||
  Fly    70 NLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLCAQAQQAMKTHGT 134

Human   132 DLWIDNMSSAVPNHSPEKKDSDFFTEHTQVLVGLGASCQQEWLTEASVIWPPFQPPAWDAPATEP 196
            .|.::....:..|.:  .::.|||           |.|..|  .:.:|
  Fly   135 KLHLEQTDKSEGNEA--AREEDFF-----------AQCDNE--VDFNV----------------- 167

Human   197 SGTQQPAPSTESSGLAQPEHGPNTDLLGTSPKASLESVYLSAKGALPARELKSSI--------IG 253
                      :::.:::.:..|.|    .:|..|:|    :.:|..|:..|.:|:        ||
  Fly   168 ----------QNNNVSKQDPNPPT----VAPVISVE----TQQGGAPSVNLLNSVVPAAVPSSIG 214

Human   254 KKKPAAAKKGLGAKK--GLGAQKVSSQSFSEIERQAQVAEKLREQQAAD--AKKQ-AEESM--VA 311
            .:|....|.||||:|  ||||.||.: :|::||.:|..|.:::...||.  .|.| ||:.:  ||
  Fly   215 ARKVQPKKGGLGARKVGGLGATKVKT-NFADIEARANAANEMKTSAAAAPVVKPQTAEDELETVA 278

Human   312 SMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSR-SSVSHSVLSEMQVIEQETPVSAK 375
            |||||||||.:.:.:||.||:.::..|.:|.||||||...| |.::||.|.:|:.|:|.....||
  Fly   279 SMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMGFNLRGSDMAHSALGDMETIQQSAAPKAK 343

Human   376 SSRSQLD-LFDDVGTFASGPPKYKDNPFSLGESFGSRWDTDAAWG----MDRVEEKEPEVTISSI 435
            .|..:.: .|.|...:.        |..|.|...||....:::.|    :|:.|  ...:...:|
  Fly   344 LSLLESENFFTDFSLYG--------NSSSGGGGGGSSEKRESSVGGTSKLDKFE--LDALGYETI 398

Human   436 RPISERATNRREVESRSSGLE-------------SSE-------------ARQKFAGAKAISSDM 474
            .||....:|...:.|||:..:             ||:             |:|||..:|...||.
  Fly   399 EPIGGSHSNITSMFSRSNDYDKPKTSAPVKKNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQ 463

Human   475 FFGREVDAEYEARSRLQQLSGSSAISSSDLFGDMD----GAHGAGSVSLGNVLPTADIAQFK--- 532
            :|..| .:..:..:.|.:..||.||||||.|||..    |.:.|.||:..  .|..|:...|
  Fly   464 YFASE-QSSADVSASLNRFQGSRAISSSDYFGDGSPGGTGGNRASSVNFS--APDLDVESVKESV 525

Human   533 -QGVKSVAGKMAVLANGVMNSLQDRYG 558
             |||..|||:::.|||.||.|.||:||
  Fly   526 RQGVHKVAGRLSNLANDVMTSWQDKYG 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARFGAP2	XP_005253223.1	PLN03114	1..510	CDD:178661	200/558 (36%)
		ArfGap_ArfGap2	5..124	CDD:350086	76/118 (64%)
		YqiK	<281..>344	CDD:441869	27/67 (40%)
ArfGAP3	NP_001097664.2	ArfGap_ArfGap2_3_like	12..127	CDD:350060	74/114 (65%)