DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SOAT2 and mdy

DIOPT Version :9

Sequence 1:	NP_003569.1	Gene:	SOAT2 / 8435	HGNCID:	11178	Length:	522	Species:	Homo sapiens
Sequence 2:	NP_609813.1	Gene:	mdy / 44887	FlyBaseID:	FBgn0004797	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	132/552 - (23%)
Similarity:	203/552 - (36%)	Gaps:	143/552 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     7 RLRLQRT------EGLGGERERQPCGDGNTETHRAPD-LVQW----TRHMEAVKAQLLEQAQGQL 60
            :||.:||      |.:..:.|:|.........||..| |..|    |.....|....|....|.|
  Fly    88 KLRYRRTQSVTRAEEISNKEEKQRRAQPGRPIHRPRDSLFSWSSGFTNFSGLVNWGFLLLCIGGL 152

Human    61 RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYH 125
            |..|:..::..|:..|                                  ||           :.
  Fly   153 RLGLENLLKYGIRINP----------------------------------LD-----------WF 172

Human   126 MFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWAR 190
            .||:|             .:||.......|.|:|...:.|.|.....:.:..:
  Fly   173 FFISG-------------HNEGEGHNALILSIYSLVHISLCLAVEKGLAMEII------------ 212

Human   191 GTWTQATGLGCALLAAHAVVLCALPV---HVAVEHQLPPASRCVLVFEQVRFLMKSYSFL----- 247
                 |.|||..:...:.|||..|||   |:.........:..|..|..|.|| |.:|::
  Fly   213 -----AEGLGLFIQIVNIVVLVCLPVVTIHLKGHAFSLMGASTVCFFYSVLFL-KLWSYVQTNMW 271

Human   248 ----------REAVPGTLRARRGEG--------------IQAP---SFSSYLYFLFCPTLIYRET 285
                      ||..|....|...:|              :|.|   ::...||||..|||.|...
  Fly   272 CRQTYYQKNPRERRPSITLAELKKGVLNGGEEDEDVSKLVQYPDNLTYKDLLYFLCAPTLCYELN 336

Human   286 YPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLS---ILHATLPG 347
            :|||..||..::.|...:.:..|.....:..:..:|...| |..|||...:.|:   :|...||.
  Fly   337 FPRTSRVRKRFLLKRLLEVVIGVNVVMALFQQWIIPSVRN-SLIPFSNMDVALATERLLKLALPN 400

Human   348 IFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLR 412
            ....|..|:...|.:|||..|:|.|.||.||.||||:.:...::||||:.||.|...::|...::
  Fly   401 HLCWLCFFYLMFHSFLNAVGELLNFADRNFYCDWWNANNIDTFWRTWNMPVHRWCVRHLYIPVVQ 465

Human   413 LLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFM-------MHDQRTG 470
             :|..:|..:.: |||.|||.|||:..      .|:.:.......||:..:       ..:::.|
  Fly   466 -MGYSSRQASTI-VFLFSAVFHEYLVS------VPLQIYKIWAFMGMMGQIPLSAISKSIEKKLG 522

Human   471 PAW-NVLMWTMLFLGQGIQVSLYCQEWYARRH 501
            |.. |:::|..:.|||.:.:..|..: |..:|
  Fly   523 PRMGNIIVWASIILGQPLCIMAYYHD-YVVQH 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOAT2	NP_003569.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		9/34 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..96		1/21 (5%)
		MBOAT	149..494	CDD:281107	102/390 (26%)
		FYXDWWN motif. /evidence=ECO:0000250\|UniProtKB:P35610	377..383		4/5 (80%)
mdy	NP_609813.1	MBOAT	115..545	CDD:294479	122/514 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275897at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2034
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950