DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VPS25 and Vps25

DIOPT Version :9

Sequence 1:	NP_115729.1	Gene:	VPS25 / 84313	HGNCID:	28122	Length:	176	Species:	Homo sapiens
Sequence 2:	NP_610398.1	Gene:	Vps25 / 35847	FlyBaseID:	FBgn0022027	Length:	174	Species:	Drosophila melanogaster

Alignment Length:	172	Identity:	74/172 - (43%)
Similarity:	115/172 - (66%)	Gaps:	1/172 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     5 FEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKL 69
            |:|||:|.|||||||||:.:|||:||..|..|.|.:.|...:.::::.: |.||||:|..|:|:|
  Fly     4 FQWPWEYTFPPFFTLQPHEETRQQQLKVWTDLFLKYLRHTNRFTLSIGD-QNSPLFHNEALKRRL 67

Human    70 PVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTNGE 134
            ..|.:..:|.||.:.|:...|||.:..:.:.|...||:|.::|.||..:||.|::.||||:.:||
  Fly    68 SPELVLAILGELERSGHANPLDKRRQEWQVYWFTLEEYGNMVYDWVQETGQTNTICTLYEIASGE 132

Human   135 DTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF 176
            :|...:|:|:|||.||.||:.|:::.:.|:|.:....|||||
  Fly   133 NTSHLDFYGVDEAVLLSALRLLEEKGRCELIEMDGSHGVKFF 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VPS25	NP_115729.1	ESCRT-II	10..139	CDD:399106	53/128 (41%)
Vps25	NP_610398.1	ESCRT-II	9..143	CDD:283517	55/134 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148275
Domainoid	1	1.000	123	1.000	Domainoid score	I5632
eggNOG	1	0.900	-	-		E1_KOG4068
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6303
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4198
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54593
OrthoDB	1	1.010	-	-		D1094121at2759
OrthoFinder	1	1.000	-	-		FOG0004660
OrthoInspector	1	1.000	-	-		oto89495
orthoMCL	1	0.900	-	-		OOG6_103180
Panther	1	1.100	-	-	LDO	PTHR13149
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1645
SonicParanoid	1	1.000	-	-		X3846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800