DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VPS25 and Vps25

DIOPT Version :9

Sequence 1:	NP_115729.1	Gene:	VPS25 / 84313	HGNCID:	28122	Length:	176	Species:	Homo sapiens
Sequence 2:	NP_001271340.1	Gene:	Vps25 / 28084	MGIID:	106354	Length:	184	Species:	Mus musculus

Alignment Length:	184	Identity:	174/184 - (94%)
Similarity:	176/184 - (95%)	Gaps:	8/184 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKL 65

Human    66 QR--------KLPVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNN 122
            ||        |||||||||||||||||||||||||:|||||||||||||||||||||||||||||
Mouse    66 QRHSLNLKPGKLPVESIQIVLEELRKKGNLEWLDKNKSSFLIMWRRPEEWGKLIYQWVSRSGQNN 130

Human   123 SVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF 176
            |||||||||:||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 SVFTLYELTSGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VPS25	NP_115729.1	ESCRT-II	10..139	CDD:399106	126/136 (93%)
Vps25	NP_001271340.1	ESCRT-II	10..153	CDD:283517	132/142 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83961852
Domainoid	1	1.000	280	1.000	Domainoid score	I17578
eggNOG	1	0.900	-	-		E1_KOG4068
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6303
Inparanoid	1	1.050	360	1.000	Inparanoid score	I14281
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54593
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004660
OrthoInspector	1	1.000	-	-		oto119795
orthoMCL	1	0.900	-	-		OOG6_103180
Panther	1	1.100	-	-	LDO	PTHR13149
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1645
SonicParanoid	1	1.000	-	-		X3846
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.290