Protein Alignment CASP10 and Casp8

DIOPT Version :9

• Sequence 1: NP_116759.2
• Gene: CASP10 / 843
• HGNCID: 1500
• Length: 522
• Species: Homo sapiens
• Sequence 2: NP_071613.1
• Gene: Casp8 / 64044
• RGDID: 620945
• Length: 482
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 195/520 - (37%)
• Similarity: 275/520 - (52%)
• Gaps: 63/520 - (12%)

Human    18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAEL 82
            :.|...|..|...||.:::..|||||:..:|.||.|..:....:|:.|..|.:|.|::..||.||
  Rat     1 MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSFLKEL 65

Human    83 LYIIRQKKLLQH-LNCTKEEVERLLPT--RQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPK 144
            |:.|.::.||.. |..:.||:.|.|..  :.:||.:|.:|::|||.:|.|:||...|||...:||
  Rat    66 LFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAYRVMLFKLSEDMDKEDLKSFKFLLITEIPK 130

Human   145 TEM----TSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEA 205
            .::    :.|.....:||:..:.|:||..|:.:|..|...||..|:.|:|..        .::..
  Rat   131 CKLQDNSSLLDIFVEMEKRTILAENNLVTLKSICFRVNRSLLGRIDDYERSS--------TERRM 187

Human   206 ESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETST 270
            .:..|||..||..|..|.   ..|:.|.                   |.|.|  .:.:|||:.
  Rat   188 STEGGEELPVSVLDEVTI---KMQDMWD-------------------SPGEQ--ESESLNSDN-- 226

Human   271 KRAAVYRMNRNHRGLCVIVNNHSF----------TSLKDRQGTHKDAEILSHVFQWLGFTVHIHN 325
                ||:|....||.|:|.||::|          ::::||:||:.|.|.||..|:.|.|.:...:
  Rat   227 ----VYQMKSKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEALSKTFKELHFEIVSFS 287

Human   326 NVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLA 390
            :.|..::..||...: :..|...|||:.|||:||..|.||.:|.....|.|:.|:||..:||.||
  Rat   288 DCTASQIHEVLVSYQ-SKDHKGKDCFICCILSHGDKGIVYGTDGKEASIYELTSYFTGSKCPSLA 351

Human   391 EKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS------IPAEADFLLGLATVPGYVSF 449
            .|||:||||||||...|.:|.: .|....||.....:||      ||.|||||||:|||...||:
  Rat   352 GKPKIFFIQACQGNNFQKAVPV-PDETGLEQEHVLEEDSSSYKNYIPDEADFLLGMATVKNCVSY 415

Human   450 RHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 514
            |....|:|||||||..|::..||.||||||||.||.|||.:.:.:...||||||.|||||||.||
  Rat   416 RDPTRGTWYIQSLCQSLRERCPRGEDILSILTGVNYDVSNKDNPRNMGKQMPQPIFTLRKKLFFP 480

Human   515  514
              Rat   481  480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASP10	NP_116759.2	DD	18..99	CDD:326335	28/81 (35%)
		DED_Caspase_10_r2	112..190	CDD:260074	29/81 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..269		7/37 (19%)
		CASc	276..514	CDD:214521	115/253 (45%)
Casp8	NP_071613.1	DED_Caspase_8_r1	3..84	CDD:260041	28/80 (35%)
		DD	98..179	CDD:417479	28/80 (35%)
		CASc	227..480	CDD:237997	116/254 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG44082
OrthoDB	1	1.010	-	-		D211777at32523
OrthoFinder	1	1.000	-	-		FOG0008092
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6038
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830