DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASP10 and Dcp-1

DIOPT Version :9

Sequence 1:NP_116759.2 Gene:CASP10 / 843 HGNCID:1500 Length:522 Species:Homo sapiens
Sequence 2:NP_476974.1 Gene:Dcp-1 / 37729 FlyBaseID:FBgn0010501 Length:323 Species:Drosophila melanogaster


Alignment Length:299 Identity:104/299 - (34%)
Similarity:152/299 - (50%) Gaps:48/299 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   241 GNRATNGA-------------------PSLVSRGMQGAS---ANTLNSETSTKR-AAVYRMNRNH 282
            |.|:.||:                   .|||..|...||   ||...:....:| |:.|.|:..|
  Fly    13 GIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKH 77

Human   283 RGLCVIVNNHSF--TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQK--QKCNP 343
            ||:.:|.|:..|  .|||.|.||:.||:.|...|:.|||.|.:|.:   .::..:|:.  :....
  Fly    78 RGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKD---CKLRDILKHVGKAAEL 139

Human   344 AHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQP 408
            .|.|.||....||:||..|.:|:.| ....:..|..:|||..||.||.||||||||||||:.:..
  Fly   140 DHTDNDCLAVAILSHGEHGYLYAKD-TQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQGDRLDG 203

Human   409 SVSIEADALNPE-QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
            .:::|......: ::.||.:  ||..||||...:|:|||.|:|::..||||:|||...|.....:
  Fly   204 GITLEKGVTETDGESSTSYK--IPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKK 266

Human   473 HEDILSILTAVNDDV----------SRRVDKQGTKKQMP 501
            : |:|::||.||..|          :..:|:|   ||:|
  Fly   267 Y-DLLTLLTFVNQRVALDFESNVPATPMMDRQ---KQIP 301

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASP10NP_116759.2 DD 18..99 CDD:326335
DED_Caspase_10_r2 112..190 CDD:260074
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..269 12/49 (24%)
CASc 276..514 CDD:214521 90/241 (37%)
Dcp-1NP_476974.1 CASc 71..313 CDD:214521 90/241 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3573
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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