DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HSDL2 and CG5590

DIOPT Version :9

Sequence 1:	NP_115679.2	Gene:	HSDL2 / 84263	HGNCID:	18572	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_651578.1	Gene:	CG5590 / 43325	FlyBaseID:	FBgn0039537	Length:	412	Species:	Drosophila melanogaster

Alignment Length:	422	Identity:	238/422 - (56%)
Similarity:	300/422 - (71%)	Gaps:	19/422 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     4 NTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKA 68
            |||:|||.|:|||||||||||.||||||:||||||:|||||:|||||.||||:||||||..||||
  Fly     3 NTGKLAGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGGKA 67

Human    69 LPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYLAS 133
            .||:||||||||:.:|||.|:.|||||||::|||||||||||.||..||.|||.|:|||||:|.|
  Fly    68 YPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAISLTNTPDTDMKRYDLMHNINTRGTFLVS 132

Human   134 KACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGE-IAVNALWP 197
            |.|:||||||..||||||||||::.|.||..|.|||:|||||||.|||||.|||.| |:||||||
  Fly   133 KVCLPYLKKSNHAHILNISPPLSMKPKWFGPHVAYTMAKYGMSMCVLGMAAEFKDEGISVNALWP 197

Human   198 KTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIF-QKPKSFTGNFVIDENILKEEGIENFDVYA 261
            :|||||||::||.||......||.:|:|||||:|. ::|:..||.|.:|:.:|:..||.:...||
  Fly   198 RTAIHTAAIEMLTGPDSAKWSRKPEIMADAAYAILTREPRQSTGQFFVDDEVLESAGITDLTEYA 262

Human   262 I--KPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGA---VEETFRIVKDSL 321
            .  :....|..|||::|....|..:..:..|.            .|.||.   :.:.||.::..|
  Fly   263 CFRENADKLMVDFFVEEKGAPVENEAAAEDAA------------APASGGDVKIPQLFRKIESLL 315

Human   322 SDDVVKATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKP 386
            |.::|..|||::.|.:||.:.||||||||:..|:.|.|.|:...|..::|.:.:|..|||||||.
  Fly   316 SPEIVSKTQAVFQFNISGAEQGTWFLDLKNGSGSCGAGTPTAAPDATLTMNSKNFFDMFSGKLKA 380

Human   387 TMAFMSGKLKIKGNMALAIKLEKLMNQMNARL 418
            ..|:|:|||||.|:...|:||||||..:.::|
  Fly   381 APAYMTGKLKISGDFQKALKLEKLMKALKSKL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSDL2	NP_115679.2	HSDL2_SDR_c	8..248	CDD:187663	171/241 (71%)
HSDL2	NP_115679.2	SCP2	319..412	CDD:376720	45/92 (49%)
CG5590	NP_651578.1	FabG	5..245	CDD:223959	171/239 (72%)
		PRK08278	7..277	CDD:181349	179/269 (67%)
		SCP2	317..406	CDD:280250	43/88 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147013
Domainoid	1	1.000	289	1.000	Domainoid score	I1577
eggNOG	1	0.900	-	-		E1_KOG4170
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75204
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1606
Isobase	1	0.950	-	0	Normalized mean entropy	S1809
OMA	1	1.010	-	-		QHG63699
OrthoDB	1	1.010	-	-		D1361949at2759
OrthoFinder	1	1.000	-	-		FOG0005600
OrthoInspector	1	1.000	-	-		oto91445
orthoMCL	1	0.900	-	-		OOG6_103987
Panther	1	1.100	-	-	LDO	PTHR42808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5337
SonicParanoid	1	1.000	-	-		X4574
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750